Progress in mosquito net coverage in Papua New Guinea
The research article describes a range of indicators of long-lasting insecticidal net ownership, access and use in Papua New Guinea in 2010/11 after an ongoing free LLIN universal coverage campaigns. It compares indicators in four regions in PNG between 2009 and 2011 and investigates a range of reasons of LLIN ownership and use.
Trends Parasitol. 2021 Nov 23:S1471-4922(21)00282-8. doi: 10.1016/j.pt.2021.11.002. Online ahead of print.ABSTRACTMalaria parasites replicate within the liver shortly after infection. This stage can be controlled by CD8 T cells, but which subsets undertake this function is unclear. Lefebvre et al. now elegantly show that effector memory T (TEM) cells are avid participants, working as a dynamic duo with liver tissue-resident memory T (TRM) cells to combat infection.PMID:34836817 | DOI:10.1016/j.pt.2021.11.002
Hong Quang Byoung-Kuk Na Apical membrane antigen-1 of Plasmodium falciparum (PfAMA-1) is a leading malaria vaccine candidate antigen. However, the genetic diversity of pfama-1 and associated antigenic variation in global P. falciparum field isolates are major hurdles to the design of an efficacious vaccine formulated with this antigen. Here, we analyzed the genetic structure and the natural selection of pfama-1 in the P. falciparum population of Vietnam. A total of 37 distinct haplotypes were found in 131 P. falciparum Vietnamese isolates. Most amino acid changes detected in Vietnamese pfama-1 were localized in the e...
This is an NIH Director's Lecture. Speaker Leslie Vosshall is interested in the molecular neurobiology of mosquito host-seeking behavior. Female mosquitoes require a blood meal to complete egg development. In carrying out this innate behavior, mosquitoes spread dangerous infectious diseases such as malaria, dengue, Zika, Chikungunya, and yellow fever. Humans attract mosquitoes via multiple sensory cues including emitted body odor, heat, and carbon dioxide in the breath. The mosquito perceives differences in these cues, both between and within species, to determine which animal or human to target for blood-feeding. We have ...
This study aimed to assess the seasonality of confirmed malaria cases in Togo and to provide new indicators of malaria seasonality to the National Malaria Control Programme (NMCP).
Condition: Malaria,Falciparum Interventions: Biological: Pfs230D1-EPA/Matrix-M Vaccine; Biological: Verorab Rabies Vaccine Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Novavax; Malaria Research and Training Center, Bamako, Mali Recruiting
Mini Rev Med Chem. 2021 Nov 24. doi: 10.2174/1389557521666211124143117. Online ahead of print.ABSTRACTAmong all the parasitic diseases in humans, malaria is the most significant and malicious one. The widespread species are Plasmodium falciparum and Plasmodium vivax, but the infection caused by former is the deadliest. According to November 2018 report of the World Health Organization (WHO), a total of 219 million cases of malaria reported globally in 2017 which led to an estimated 435,000 deaths. Mortality due to malaria is estimated at 1.5 - 2.7 million deaths each year. Among all the complications associated with Plasmo...
We report a case of scrub typhus-associated nephrotic syndrome with acute kidney injury in a five-year-old female with uneventful outcome.PMID:34818870 | DOI:10.4103/0972-9062.321744
CONCLUSION: Study revealed that in Kangra district, An. fluviatilis sibling-species U is predominant followed by species T, and both are non-vectors. The absence of malaria parasite and zoophagic nature of An. fluviatilis established through blood meal analysis, confirmed that both U and T are non-vector sibling-species.PMID:34818868 | DOI:10.4103/0972-9062.321745
CONCLUSION: This is a unique study on diversity of microbiota of An. stephensi from breeding water, developmental stages and adults. Different culture media used enhanced the isolation of diverse bacteria. The presence of Micrococcus and Leucobacter in different life stages indicates their adaptation in An. stephensi as symbionts which need further evaluation for their role in paratransgenesis.PMID:34818867 | DOI:10.4103/0972-9062.289392
CONCLUSION: The present study showed that despite having congenial environmental conditions, Jammu division faces a great threat of VBDs and the increase in the number of cases in future cannot be ruled out. Japanese encephalitis registered its presence for the first time in the division.PMID:34818860 | DOI:10.4103/0972-9062.321746