Hypoxia and Inactivity Related Physiological Changes (Constipation, Inflammation) Are Not Reflected at the Level of Gut Metabolites and Butyrate Producing Microbial Community: The PlanHab Study

Robert Šket, Nicole Treichel, Tadej Debevec, Ola Eiken, Igor Mekjavic, Michael Schloter, Marius Vital, Jenna Chandler, James M. Tiedje, Boštjan Murovec, Zala Prevoršek, Blaž Stres
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Authors: Sinagra E, Rossi F, Raimondo D, Conoscenti G, Anderloni A, Guarnotta V, Maida M Abstract INTRODUCTION: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. AREAS COVERED: Aim of this article is...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
The simultaneous occurrence of Hirschsprung disease (HD) and anorectal malformation (ARM) is extremely rare, with only a very limited amount of cases published in the literature.Constipation is a major problem in patients operated for ARM, and biopsies from the distal rectum in patients with ARM may not show ganglion cells owing to different reasons, leading to a false positive diagnosis of HD. A pull-through procedure for HD after previous anorectoplasty for ARM always leads to fecal incontinence.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
AbstractBackgroundClinical trials have shown the safety and clinical superiority of erenumab compared to placebo in chronic migraine (CM). The aim of this analysis is to evaluate the effectiveness and tolerability of erenumab in a real-world setting in patients with refractory CM.MethodsThis is a prospective single centre real-world audit conducted in patients with CM with and without medication overuse, refractory to established preventive medications, who received monthly erenumab for 6 months.ResultsOf 164 patients treated, 162 patients (female  = 135, mean age 46 ± 14.3 years o...
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research
Inadequate bowel preparation (IBP) negatively affects the efficacy and quality of colonoscopy in routine clinical practice. Although several studies have reported the risk factors of IBP including age, diabetes mellitus, and constipation, little is known about the information on variation of risk factors of IBP according to age.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
This study will determine whether magnesium oxide or naldemedine is more effective for the prevention of OIC.Trial registrationUniversity Hospital Medical Information Network (UMIN) Clinical Trials Registry,UMIN000031891. Registered March 25, 2018.
Source: Trials - Category: Research Source Type: clinical trials
High quality bowel preparation is crucial for an effective examination of the colon during colonoscopy. Diabetes, chronic constipation, spinal cord injury, and the use of medications such as narcotics and tricyclic antidepressants are well known predictors of inadequate bowel preparation. The 2014 US Multi-Society Task Force guidelines do not recommend the use of a specific bowel regimen in high risk patients, and limits its statement to the favorable use of additional purgatives in this group of patients (weak recommendation, low quality evidence).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
Conclusions: MLD significantly reduced FC symptoms and MLD had greater improvements than AM or ES.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
The quality of bowel preparation (BP) before colonoscopy plays a pivotal role in the safety, efficacy and quality of the outcome of colonoscopy. Inadequate BP is evident in more than 25% of all colonoscopies. High-quality BP is critical for detection of precancerous lesions.. Inadequate BP is correlated with patient-specific factors including age, male gender, medications, comorbidities such as chronic constipation, diabetes, gastrointestinal surgery, cirrhosis, stroke, and irritable bowel disease (IBD).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
ConclusionEX did not confer benefit in the functional outcome but carried a high risk of complications, often needing ACE or stoma. By adhering to strategies discussed, we reduced the incidence of megarectum and have avoided EX since 2013.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Conditions:   Opioid-induced Constipation;   Cancer;   Cancer Pain Intervention:   Other: Treatment algorithm for OIC Sponsors:   Royal Surrey County Hospital NHS Foundation Trust;   Kyowa Hakko Kirin UK, Ltd. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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