Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models
Pharmacogenomics Ahead of Print.
Publication date: 10 November 2020Source: Composites Science and Technology, Volume 200Author(s): Ying-Lei Wang, Mariamelia Stanzione, Hesheng Xia, Giovanna G. Buonocore, Elena Fortunati, Saulius Kaciulis, Marino Lavorgna
Publication date: November 2020Source: Journal of Functional Foods, Volume 74Author(s): Sok Kuan Wong, Kok-Yong Chin, Fairus Ahmad, Soelaiman Ima-Nirwana
Contributors : Kristoffer G Rigbolt ; Helene ÆgidiusSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo improve the understanding of the complex biological processes underlying the development of non-alcoholic steatohepatitis (NASH), a multi-omics approach combining bulk RNA-sequencing based transcriptomics, quantitative proteomics and single-cell RNA-sequencing was used to characterize tissue biopsies from histologically validated diet-induced obese (DIO) NASH mice compared to chow-fed controls. Bulk RNA-sequencing and proteomics showed a clear distinction between phenotypes and...
Conclusions: Findings revealed several gaps in resources identified by adolescents and young adults that are needed to adequately address substance use, which provide important next steps for substance use prevention among youth. PMID: 32938267 [PubMed - as supplied by publisher]
CONCLUSIONS: In this population-based cross-sectional analysis, we found an association between selected PFAAs and self-reported gout. We also confirmed previous reports of an association between several PFAAs and hyperuricemia. Our study suggests that exposure to PFAAs may be a risk factor for hyperuricemia and gout. PMID: 32590180 [PubMed - indexed for MEDLINE]
iou Low power consumption is one of the critical factors for successful Internet of Things (IoT) applications. In such applications, gas sensors have become a main source of power consumption because energy conversion efficiency of the microheater is relative over a wide range of operating temperatures. To improve the energy-conversion efficiency of gas-sensor microheaters, this paper proposes integrated switch-mode DC-to-DC power converter technology which we compare with traditional driving methods such as pulse-width modulation and the linear mode. The results indicate that energy conversion efficiency with this pro...
Authors: Hwang S, Ren T, Gao B Abstract Obesity and binge drinking often coexist and work synergistically to promote steatohepatitis; however, the underlying mechanisms remain obscure. In this mini-review, we briefly summarize clinical evidence of the synergistical effect of obesity and heavy drinking on steatohepatitis and discuss the underlying mechanisms obtained from the study of several mouse models. High-fat diet (HFD) feeding and binge ethanol synergistically induced steatohepatitis and fibrosis in mice with significant intrahepatic neutrophil infiltration; such HFD-plus-ethanol treatment markedly up-regulat...
CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher]
Hospitals and emergency services should be prepared for a possible influx of adolescents and young adults with alcohol-related emergencies as their localities open up after COVID-19 lockdowns, suggests astudy in the Journal of Adolescent Health. The study found that the proportion of alcohol-related emergency department (ED) visits to two Italian hospitals jumped for this population in the weeks following the end of this spring ’s lockdown compared with the same time frame in 2019.Veronica Grigoletto, M.D., of the University of Trieste and colleagues analyzed data on ED visits of patients aged 13 to 24 years that occ...
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC05387B, CommunicationSilvia Rodr íguez-Nuévalos, Ana M. Costero, Pau Arroyo, José A. Sáez, Margarita Parra, Félix Sancenón, Ramón Martínez-Máñez Chemosensors for naked-eye detection of the submission drug GHB in beverages. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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