Headaches, fatigue, dizziness and memory problems: Hughes Syndrome explained

AS PART of Hughes Syndrome Awareness Month, experts explain the little-known disease, also known as Antiphospholipid Syndrome and more common than Parkinson's and multiple sclerosis, and advise what to do if you think might be at risk
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Two drugs, voxelotor (Oxbryta) and crizanlizumab-tmca (Adakveo), have been approved to treat sickle cell disease.The most common adverse effects of voxelotor are diarrhea, headache, abdominal pain, nausea, fatigue, rash, and fever. Hypersensitivity reactions are also possible.The most common adverse effects of crizanlizumab-tmca are back pain, nausea, fever, and arthralgia. Serious adverse effects include infusion-related reactions and interference with automated platelet counts.
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
Authors: Ingawale DK, Mandlik SK Abstract Inflammation is a physiological intrinsic host response to injury meant for removal of noxious stimuli and maintenance of homeostasis. It is a defensive body mechanism that involves immune cells, blood vessels and molecular mediators of inflammation. Glucocorticoids (GCs) are steroidal hormones responsible for regulation of homeostatic and metabolic functions of body. Synthetic GCs are the most useful anti-inflammatory drugs used for the treatment of chronic inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), allergies, multiple sclerosis, te...
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
We present the case of a woman with DBS as a treatment for PD, safely treated with ECT for a psychotic depression. Depression severity and motor changes were evaluated on a weekly basis using the Montgomery-Åsberg Depression Rating Scale and the Unified Parkinson's Disease Rating Scale. During the course of ECT, the Montgomery-Åsberg Depression Rating Scale score declined from 34 to 13, and the Unified Parkinson's Disease Rating Scale motor score from 44 to 12 with positive impact on rigidity. Considering the positive impact of ECT on the motor function in our patient, new research should look into ECT as an au...
Source: The Journal of ECT - Category: Psychiatry Tags: Case Reports Source Type: research
New MRI technique reveals iron accumulations that could lead to Parkinson ’s dementia prediction.
Source: Diagnostic Imaging - Category: Radiology Authors: Tags: Brain MRI Dementia Parkinsons Disease Source Type: news
Publication date: Available online 19 February 2020Source: Life SciencesAuthor(s): Liu Yang, Xinyan Han, Jinfeng Yuan, Faping Xing, Zhixing Hu, Fei Huang, Hui Wu, Hailian Shi, Ting Zhang, Xiaojun WuAbstractAimsDendritic cells (DCs) actively participate in the pathogenesis of multiple sclerosis (MS), an autoimmune disease. Astragaloside IV (ASI), an active monomer isolated from the Chinese medicine Astragalus membranaceus, has a wide range of pharmacological effects. We aimed to elucidate the effects of ASI on the development of DCs in the early stage of MS/EAE.Main methodsThe mice were administered with ASI (20 mg/kg) da...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Ya Ma, Qiong Hu, Cheng Liu, Lishi WangAbstractIn this manuscript, a nanospherical conjugated microporous polymer (CMP) was synthesized. This material together with graphene nanosheets (GS) was used as electrode modification materials to construct a molecularly imprinted electrochemical sensor for high sensitivity detection of α-Synuclein (α-Syn). The MIP sensor was synthesized by electropolymerization pyrrole and characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV) and differential...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Conditions:   Dystonia Disorder;   Parkinson Disease Interventions:   Drug: Botulinum toxin type A;   Drug: Placebo Sponsors:   University of Calgary;   Allergan Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Neural implants may provide treatment options for a wide variety of ailments, including Parkinson’s and epilepsy, but such devices have to work for long periods of time in a very difficult environment inside the cranium. One challenge is provid...
Source: Medgadget - Category: Medical Devices Authors: Tags: Materials Neurology Neurosurgery Source Type: blogs
BACKGROUND: Nocturnal hypokinesia commonly affects Parkinson's disease (PD) patients, manifesting primarily as an impaired ability to turn in bed and sleeping in specific positions, such as prone that potentially poses the risk of positional asphyxia. ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
ConclusionHigh index of suspicion for thrombophilic disorders is required in postpartum patients presenting with respiratory distress as prompt diagnosis and urgent intervention can save patient’s life.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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