Medical News Today: Ketogenic diet may protect against gout
Could the low-carb, high-fat diet be helpful in treating the symptoms of gout? A new study investigates how the diet affects rodents and humans.
Systemic reviews and meta-analyses suggest hyperuricemia is a cardiovascular risk factor. The effects of xanthine oxidase inhibitors on cardiac outcomes remain unclear. We assessed the effects of febuxostat and allopurinol on mortality and adverse reactions in adult patients with hyperuricemia.
Condition: Gout Interventions: Biological: Pegloticase with MTX; Biological: Pegloticase with placebo for MTX Sponsor: Horizon Pharma Rheumatology LLC Recruiting
Provisional gout remission criteria including five domains (serum urate, tophus, flares, pain due to gout, and patient global assessment) have been proposed. The aim of this study was to test the concurrent va...
Publication date: Available online 20 June 2019Source: Journal of NeuroradiologyAuthor(s): Marc Denève, Damien Biotti, Sofia Patsoura, Marine Ferrier, Zuzana Meluchova, Laurence Mahieu, Françoise Heran, Catherine Vignal, Romain Deschamps, Olivier Gout, Nicolas Menjot de Champfleur, Xavier Ayrignac, Clarisse Carra Dallière, Pierre Labauge, Cécile Dulau, Thomas Tourdias, Hervé Dumas, Christophe Cognard, David Brassat, Fabrice BonnevilleAbstractThe spectrum of Myelin Oligodendrocytes Glycoprotein (MOG) antibody disease constitutes a recently described challenging entity, referring to a relat...
The Duke University emeritus professor was an expert in purine biosynthesis and the genetics of gout.
ConclusionFurther studies are necessary to clarify the observed association, and public health strategies to reduce heavy metal exposure may be necessary for decreasing the potential harmful effects of hyperuricemia.
AbstractHepatocyte nuclear factor-1 β (HNF-1β) is an essential transcription factor that regulates the development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract. Humans who carryHNF1B mutations develop heterogeneous renal abnormalities, including multicystic dysplastic kidneys, glomerulocystic kidney disease, renal agenesis, renal hypoplasia, and renal interstitial fibrosis. In the embryonic kidney, HNF-1 β is required for ureteric bud branching, initiation of nephrogenesis, and nephron segmentation. Ablation of mouseHnf1b in nephron progenitors causes defective tubulogene...