Link between herpes in pregnancy and autism is unconfirmed

Conclusion This was a Norwegian case-control study that looked at whether maternal infections during pregnancy are associated with the risk of neurological developmental disorders such as autism spectrum disorders (ASDs) in their children. The study initially found no association between any of the pathogens during pregnancy or after delivery, and the development of ASD in boys or girls. Further investigations suggested that high levels of HSV-2 virus antibodies during mid-pregnancy were associated with increased risk of the development of ASD in boys. The researchers suggest that the suspected risk of ASD associated with high levels of virus is not down to the HSV-2 virus itself but the impact of inflammation and the subsequent activation of the immune system on child development during pregnancy However, while this finding has been widely reported in the media, it is based on just 14 women so is not reliable. Performing repeated unplanned analyses is bound to come up with some association in the end through sheer chance. It is important that pregnant women do take precautions to prevent herpes infection during pregnancy, especially the third trimester, as there is a risk of passing the virus on to the baby. More research would be needed to confirm the speculations that herpes infection during pregnancy can increase the risk of autistic spectrum disorder.   Links To The Headlines Pregnant women infected with herpes are ‘TWICE as likely to have a baby with ...
Source: NHS News Feed - Category: Consumer Health News Tags: Pregnancy/child Neurology Mental health Source Type: news

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HPV DNA detection in urine samples of women: "An efficacious and accurate alternative to cervical samples?" Expert Rev Anti Infect Ther. 2019 Sep 13;: Authors: Pattyn J, Van Keer S, Téblick L, Van Damme P, Vorsters A Abstract Cervical cancers are caused by persistent human papillomavirus (HPV) infections [1]. To date, HPV DNA testing using clinician-obtained cervical cells is the reference for identifying cervical infection. However, great interest has been shown for the use of self-sampling methods to detect HPV [2]. One method for self-sampling to be considered is the collection of f...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
ConclusionActual body weight and bone marrow involvement may be utilized as potential predictive indicators of R-IRRs. Further study is needed to validate these indicators and determine appropriate utilization in practice.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
Conclusion: Specific contexts appeared to be associated with problematic drinking for both sexes. Among both men and women, "social drinking" was associated with problematic drinking. Both "home drinking" (men) and "daytime drinking" (women) contexts, were associated with problematic drinking and depressive symptoms. Targeted alcohol-focused interventions need to address co-occurring mental health issues. PMID: 31519127 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Conclusions: Reduced expression of ER stress markers in trophoblast cells against increased VEGF highlighted a new window to explore prospective drugs that can be designed to modulate the activities of various ER stress sensors in order to alleviate ER stress in pregnant women with preeclampsia. PMID: 31517301 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Abstract Objective: The aims of this study were to determine the prevalence of human papillomavirus (HPV) infection in women treated for infertility and oocyte donors, and to investigate the possible influence of HPV infection on reproductive outcomes. Study design: In this observational laboratory-based study, cervical swabs were collected from oocyte donors (n = 207), and women treated for infertility (n = 945) and analysed for the presence of high-risk HPV (hrHPV) genotypes using the cobas® 4800 HPV Test and PapilloCheck® HPV-Screening. Associations between hrHPV positiv...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Authors: Friedman SH, Tamburello AC, Kaempf A, Hall RCW Abstract Prescribing for women in jails and prisons requires special consideration and should be informed by extant evidence. Incarcerated women have higher rates of mental illness than both females in the community and incarcerated men. Medication administration concerns that may disproportionately affect female prisoners include drug-drug interactions with contraceptives, intermittent dosing schedules, and concerns about metabolic side effects. Further, pregnancy, lactation, and menopause may all affect medication choices. Incarcerated women frequently have ...
Source: Journal of the American Academy of Psychiatry and the Law - Category: Medical Law Tags: J Am Acad Psychiatry Law Source Type: research
THE GORDON WILSON LECTURE: THE HEPATITIS C VIRUS: FROM HIPPOCRATES TO CURE. Trans Am Clin Climatol Assoc. 2019;130:104-118 Authors: Alter HJ Abstract The modern age of viral hepatitis began in the early 1960s with the serendipitous discovery of the Australia antigen, a protein that was later shown to represent the envelope of the hepatitis B virus leading to its designation as the hepatitis B surface antigen. This was the first marker for any hepatitis virus and became not only a diagnostic assay, but also a mandatory blood donor screening test and the basis for the first generation hepatitis B vaccine...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
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Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
Authors: Falougy HE, Filova B, Ostatnikova D, Bacova Z, Bakos J Abstract Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both s...
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
Publication date: Available online 14 September 2019Source: Biochemical Engineering JournalAuthor(s): Xiaoxia Dai, Can Jian, Li Na, Xiaofeng Wang, Yu Dai, Dexin LiAbstractHantaan virus-like particles (VLPs) have been produced and purified by co-expressing Hantaan virus nucleocapsid (N) protein and glycoproteins (Gn and Gc) in baculovirus insect cell systems. The potential of VLPs as a vaccine was evaluated by comparing the humoral immune response and neutralizing antiserum induced by the purified VLP and the recombinant baculovirus bearing the Hantaan virus glycoproteins alone. After immunization of C57BL/6 mice, Hantaan V...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
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