Malaria: Hitches and Hopes.

Malaria: Hitches and Hopes. Mini Rev Med Chem. 2014 Apr 28; Authors: Marella A, Verma G, Shaquiquzzaman M, Akhter M, Alam MM Abstract Malaria, a devastating infectious disease caused by parasites of Plasmodium genera is transmitted from person to person through bites of infected mosquitoes. It generally traps underdeveloped nations with poor infrastructure and high population density. It has attracted considerable attention from academic institutions, pharmaceutical industries and government agencies but the efforts to eradicate this threat face a number of technical, economic, financial and institutional hurdles. In the absence of clinically proven vaccines to combat malaria,chemotherapy continues to be the best available option, although it suffers from a big loophole of resistance. Emergence of resistance is associated with the two phases of Plasmodium's life cycle: asexual in humans and sexual in mosquito, which are intricate to target simultaneously. Consequently, the search for novel antimalarial agents is a never-ending task for scientists and chemists. This review aims at highlighting the currently used antimalarial agents, targets for the therapy and present scenario in the development of new antimalarial drugs to combat this global problem. PMID: 24766385 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research

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Parasites genes prepare it for the unexpected, but could be exploited to fight the disease More at This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Parasites genes prepare it for the unexpected, but could be exploited to fight the disease More at This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Abstract Malaria is a disease of public health importance in many parts of the world. Currently, there is no effective way to eradicate malaria, so developing safe, efficient, and cost-effective vaccines against this disease remains an important goal. Current research on malaria vaccines is focused on developing vaccines against pre-erythrocytic stage parasites and blood-stage parasites or on developing a transmission-blocking vaccine. Here, we briefly describe the progress made towards a vaccine against Plasmodium falciparum, the most pathogenic of the malaria parasite species to infect humans. PMID: 3168740...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
(PLOS) Female mosquitoes that have mated are more likely to transmit malaria parasites than virgin females, according to a study published Nov. 7 in the open-access journal PLOS Pathogens by Farah Dahalan of Imperial College London, Mara Lawniczak from the Wellcome Sanger Institute, and colleagues.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Date: Tuesday, 11 12, 2019; Speaker: Kirk W. Deitsch, Professor, Weill Cornell Medicine, Graduate School of Medical Sciences; 12735 Twinbrook Pkwy; 2nd Floor Conference Room
Source: NIH Calendar of Events - Category: American Health Source Type: events
Abstract Plasmodium vivax, the chronic relapsing human malaria parasite with the most widespread distribution, possesses proteins associated with the merozoite surface that could be targets for host immune responses and potential vaccine candidates. Of these, the merozoite surface protein 3 of P. vivax (PvMSP3) is an attractive vaccine target as well as a genetic marker for epidemiological surveillance. PvMSP3 comprises a group of protein members encoded by a multigene family. Although some protein members, i.e. PvMSP3α and PvMSP3β, have been targets for molecular and immunological investigations, the m...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Insecticides formulated into products that target Anopheles mosquitos have had an immense impact on reducing malaria cases in Africa. However, resistance to currently used insecticides is spreading rapidly and th...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Conclusion: Low to moderate genetic diversity of P.falciparum strains and MOI disparities were found in Senegal.Keywords: Senegal, MOI, Genetic diversity, msp1, msp2.
Source: African Health Sciences - Category: African Health Source Type: research
Publication date: November 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 7Author(s): Radhakrishnan Mahesh, Sourabh Mundra, Thangaraj Devadoss, Lakshmi P. KotraAbstractThe cysteine protease, falcipain-2 is an important drug target in human malaria parasite Plasmodium falciparum. A new series of 2-(4-(substituted benzoyl)-1,4-diazepan-1-yl)-N-phenylacetamide derivatives 5(a–t) were designed as per pharmacophoric requirements of falcipain-2 inhibitors using ligand-based approach. The target compounds were synthesized from the key intermediate, 2-(1,4-Diazepan-1-yl)-N-phenylacetamide, by coupling it with app...
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research
iey F Abstract Artemisinin is the most widely-used compound against malaria and plays a critical role in the treatment of malaria worldwide. Resistance to artemisinin emerged about a decade ago in Southeast Asia and it is paramount to prevent its spread or emergence in Africa. Artemisinin has a complex mode of action and can cause widespread injury to many components of the parasite. In this review, we outline the different metabolic pathways affected by artemisinin, including the unfolded protein response, protein polyubiquitination, proteasome, phosphatidylinositol-3-kinase, and the eukaryotic translation initia...
Source: Trends in Parasitology - Category: Parasitology Authors: Tags: Trends Parasitol Source Type: research
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