Antimicrobial resistance - a ticking bomb!

Antimicrobial resistance - a ticking bomb! Indian Pediatr. 2014 Mar 8;51(3):171-2 Authors: Yewale VN PMID: 24736901 [PubMed - in process]
Source: Indian Pediatrics - Category: Pediatrics Authors: Tags: Indian Pediatr Source Type: research

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ConclusionThe prevalence of MDR-GNB in Iranian burn patients is very high. Thus, a comprehensive infectious control programme, a reduction in the use of antibiotic prophylaxis, and thorough information regarding antimicrobial resistance patterns is required.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Vladimir Rafalskiy, Dmitry Pushkar, Sergey Yakovlev, Oleg Epstein, Mikhail Putilovskiy, Sergey Tarasov, Alexey Glazunov, Sergeiy Korenev, Ekaterina Moiseeva, Natalia GorelyshevaAbstractBackgroundUrinary tract infections (UTIs) are among the most common bacterial infections in clinical practice. The aim of the RESOURCE study was to determine the antimicrobial resistance profile of gram-negative bacteria isolated from outpatient urine samples collected across the Russian Federation.MethodsA total of 96,781 urine s...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusioncarbapenem-resistance is frequent among ESBL-E in Nigeria and mainly associated with blaNDM. Genotyping suggest that these clones possibly originated from South-East Asia.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
CONCLUSIONImmunosuppression, ICU admission, antibiotics exposure including carbapenems, quinolones, glycopeptides, β‑lactams and β‑lactamase inhibitor combinations, surgery, mechanical ventilation, central venous catheterization, indwelling catheter and nasogastric catheter intubation are risk factors for CRKP infection. These conditions have to be considered in clinical practice
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study sought to quantify the effect of AMR on treatments for pediatric pneumococcal disease in Ethiopia. We developed the DREAMR (Dynamic Representation of the Economics of AMR) model that simulated children younger than 5 years who acquire pneumococcal disease (pneumonia, meningitis, and acute otitis media) and seek treatment from various health facilities in Ethiopia over a year. We examined the AMR levels of three antibiotics (penicillin, amoxicillin, and ceftriaxone), treatment failures, and attributable deaths. We used a cost-of-illness method to assess the resulting economic impact of AMR from a societal perspec...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
ConclusionsA real-time PCR-based assay was designed to detect the genomic DNA of strains harbouring mosaic penA-59.001 (GU140106), penA-60.001 (FC428), and penA-64.001 (A8806) alleles and to discriminate them from N. gonorrhoeae and Neisseria spp. strains harbouring other genes.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Abstract Campylobacter jejuni and C. coli are leading causes of human foodborne illness with poultry as a major vehicle. Turkeys are frequently colonized with Campylobacter but little is known about Campylobacter survival in turkey feces, even though fecal droppings are major vehicles for Campylobacter within-flock transmission as well as for environmental dissemination. Our objective was to examine survival of Campylobacter, including different strains, in freshly-excreted feces from naturally-colonized commercial turkey flocks and in suspensions of turkey feces in water from the turkey house. Fecal and water sus...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Abstract Antibiotic use in cattle can select for multidrug-resistant Salmonella enterica, which is considered a serious threat by the U.S. Centers for Disease Control and Prevention. A randomized controlled longitudinal field trial was designed to determine the long-term effects of a single dose of ceftiofur or tulathromycin on Salmonella population characteristics among cattle feces, peripheral lymph nodes, and hides. A total of 134 beef cattle from two sources was divided among 12 pens, with cattle in each of the three-pen blocks receiving either a single dose of ceftiofur or tulathromycin on Day 0, or else neit...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
This study focused on the Escherichia coli possessing bla CTX-M genes in wastewater inflows. Crude 12 inflow water samples from wastewater treatment plant (WWTP) A and two samples each from other three WWTPs were collected in 2017 and 2018. A total of 73 E. coli isolates with 31 different STs harboring distinctive bla CTX-M gene repertoires were detected. In WWTP A influents, the bla CTX-M-14 (14 isolates) was dominant, followed by bla CTX-M-15 (12 isolates), bla CTX-M-27 (10 isolates). The chimeric bla CTX-M-64 and bla CTX-M-123 were each identified in one of E. coli isolates from the same WWTP A inflow port. The bla CTX-...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
This study aimed to understand if specialty impacts quantitative measures of prescribing practice.MethodsWe prospectively analysed the antibiotic prescribing across general medical and surgical teams for acutely admitted patients. Over a 12-month period (June 2016 – May 2017) 659 patients (362 medical, 297 surgical) were followed for the duration of their hospital stay. Antibiotic prescribing across these cohorts was assessed using Chi-squared or Wilcoxon rank-sum, depending on normality of data. The t-test was used to compare age and length of stay. A logi stic regression model was used to predict escalation of anti...
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research
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