Corrections Correction to Lancet Oncol 2016; 17: e335

Kumar S, Paiva B, Anderson KC, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol 2016; 17: e328 –46—In table 4 of this Review, the label for the fourth row of IMWG MRD criteria should have read Imaging plus MRD-negative. This correction has been made to the online version as of Aug 30, 2016.
Source: The Lancet Oncology - Category: Cancer & Oncology Tags: Corrections Source Type: research

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Authors: Lirici MM, Bongarzoni V, Paolantonio P, Leggeri T, Pirillo SP, Romeo V Abstract Bochdaleck hernia (BH) is a congenital diaphragmatic hernia that presents after birth with respiratory symptoms and needs surgical treatment in the neonatal period. However, there are some rare cases of adult presentation, which require surgery to avoid complications. BHs can be treated through several approaches, including laparoscopy. Laparoscopic treatment of a giant BH was successfully attempted on a woman affected by multiple myeloma, with severe dyspnoea and dysphagia. Preoperative work-up included chest X ray, CT-scan an...
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Publication date: Available online 12 July 2019Source: Research in Veterinary ScienceAuthor(s): Marco Caldin, Michela Campigli, Andrea Zoia, Anna Zanella, Giovanna Bertolini, Tommaso Furlanello, George LubasAbstractMultiple myeloma (MM) is a tumor of plasma cells representing approximately 1% of all canine tumors. Clinical evident bleeding is often referred to as the main finding. The aim of the study was to evaluate the occurrence of clinical bleedings in dogs with MM and its prognostic implications compared to a population of dogs not affected by MM.Two groups of dogs (# 78 each) individually matched for breed, age and g...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Publication date: Available online 12 July 2019Source: Protein Expression and PurificationAuthor(s): Patrick J. McDevitt, Jessica L. Schneck, Elsie Diaz, Wangfang Hou, Michael J. Huddleston, Rosalie E. Matico, Patricia M. McCormick, Robert B. KirkpatrickAbstractWolf-Hirschhorn Syndrome Candidate 1 (WHSC1; also known as NSD2) is a SET domain-containing histone lysine methyltransferase. A chromosomal translocation occurs in 15–20% of multiple myeloma patients and is associated with increased production of WHSC1 and poor clinical prognosis. To define the substrate requirements of NSD2, we established a platform for the ...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
Publication date: Available online 13 July 2019Source: Annals of Medicine and SurgeryAuthor(s): Vladimir Popovski, Suzana Dvojakovska, Alberto Benedetti, Goran Panchevski, Aleksandar Stamatoski, Vesna JanevskaAbstractSolitary plasmacytoma (SP) is an early-stage plasma cell malignancy that is in between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) along the spectrum of plasma cell disorders. SPs can be divided into 2 groups according to location: solitary bone plasmacytoma (SBP) – these occur most commonly in the vertebrae and secondarily in long bones, and extramedullary plasmac...
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Condition:   Relapsed and/or Refractory Multiple Myeloma Intervention:   Drug: TAK-169 Sponsor:   Millennium Pharmaceuticals, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Bai Y, Chim CS Abstract OBJECTIVE: Buffy coat and ficoll of bone marrow (BM) are viable options for the study of minimal residual disease (MRD) in multiple myeloma (MM). As yet, there is no data about the superiority of either sample types. Herein, we aimed to address this issue. METHODS: Forty pairs of ficolled BMs and BM buffy coats of 19 MM patients were studied for MRD by allele-specific oligonucleotide real-time quantitative PCR, with patient-specific primers/probes whenever appropriate. RESULTS: There were 41 pairs of MRD data for comparison analysis due to one patient with biclonal disease...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Over the last decade autologous stem cell transplantation (ASCT) has emerged as the standard of care in the management of Multiple Myeloma (MM). However, the cases of early relapse (within 36 months) after the stem cell rescue remains a significant challenge. For a lot of practical purposes, it is crucial to identify whether a patient undergoing ASCT falls into the high-risk group (likely to relapse within 36 months) or a low risk one. Our analysis showed that existing MM staging systems (International Staging System or ISS and Durie Salmon Staging or DSS) are not sufficient to discriminate between the risk groups si...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractThe diagnosis of bone lesions is a fundamental part of the study of skeletal remains, both in the archeological and forensic context. On the one side, the literature proved the relevance of radiography for the detection of bone lesions; on the other side, the careful macroscopic observation of the morphology of bone lesions is often underestimated. For this study, we examined and performed plain radiography on 14 skeletons of the CAL Milano Cemetery Skeletal Collection diagnosed with rheumatoid arthritis, diabetes, multiple myeloma, metastatic cancer, and osteomalacia to compare the macroscopic morphology and radio...
Source: International Journal of Legal Medicine - Category: Medical Law Source Type: research
Human IgG2 antibody displays distinct therapeutically-useful properties compared with the IgG1, IgG3, and IgG4 antibody subclasses. IgG2 is the second most abundant IgG subclass, being able to bind human FcγRII/FcγRIII but not to FcγRI or complement C1q. Structural information on IgG2 is limited by the absence of a full-length crystal structure for this. To this end, we determined the solution structure of human myeloma IgG2 by atomistic X-ray and neutron-scattering modeling. Analytical ultracentrifugation disclosed that IgG2 is monomeric with a sedimentation coefficient (s20, w0) of 7.2 S. IgG2 dimer for...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Immunology Source Type: research
[Vanguard] Doctors at a private hospital in Benin City, Edo State, Celltek Healthcare Medical Centre, have successfully performed stem cells transplant on a 62-year-old patient with multiple myeloma.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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