Atherosclerosis Risk: Psoriasis Stronger Predictor Than Diabetes Atherosclerosis Risk: Psoriasis Stronger Predictor Than Diabetes

Associations between atherosclerosis risk and type 2 diabetes appear primarily driven by weight, whereas risk with psoriasis is independent of known cardiometabolic risk factors.Medscape Medical News
Source: Medscape Dermatology Headlines - Category: Dermatology Tags: Dermatology News Source Type: news

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Conclusion Analysis of the pleiotropic effects of IL-33 on multiple immunological cells (macrophages, mastocytes), as well as neurological cells of medulla oblongata, dorsal root ganglion, antigen-induced arthritis system, carrageen, and formalin, shows that this alarmin plays curtail, yet not fully known role in mediating inflammation, especially in chronic inflammatory pulmonary diseases such as asthma, COPD, and OSA. Taken into consideration the engagement in this process, in particular of mastocytes and their secretion of CXCL2, 4, 8, and other cytokines, there is no doubt regarding the etiopathogenic role of IL-33 in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
How can conventional dietary advice gotten it so wrong? Rather than eating plenty of “healthy whole grains,” people on the Wheat Belly lifestyle eat absolutely no grains and enjoy spectacular weight loss and reversal of hundreds of health conditions as a result. Unfortunately, many people view this as a “gluten-free” lifestyle which is incorrect. Here are 10 reasons why no bagels, pretzels, or sandwiches made from wheat flour should ever cross human lips. Gliadin-derived opioid peptides (from partial digestion to 4- and 5-amino acid long fragments) increase appetite substantially–as do related...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle Gliadin gluten Inflammation Weight Loss Source Type: blogs
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, we hypothesized that appropriate epigenomic elements (H3K27ac marks for active enhancers) can guide us to reveal valuable information about the loci with suggestive evidence of association. Our aim is to investigate these loci and explore how they may lead to the development of PsA. We evaluated this potential by investigating the genes connected with these loci from the perspective of pharmacogenomics and gene expression. We illustrated that markers with suggestive evidence of association outside the MHC region are enriched in H3K27ac marks for osteoblast and chondrogenic differentiated cells; using pharmac...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
We presented a new statistic T to use large public database as reference to reduce concern of potential population stratification. And the new statistic proposed here is effective to discover novel genome-wide significant loci with both small and large sample sizes. Author Contributions YW conceived the idea and developed the software. YL, MH, and XL contributed data analysis, generating tables and figures, and manuscript writing. YW, YL, MH, XL, YS, and LJ contributed the theoretical analysis and manuscript revision. MX helped support the GWAS datasets. YW, YL, MH, XL, MZ, JW, and MX contributed to scientific discussion...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study aimed to elucidate the pathophysiological link between psoriasis, glucose metabolism, and T2DM.The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
It has been reported that GLP-1 analogue can improve the skin lesions of psoriasis.However further research is needed to confirm that finding.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
CONCLUSION: Metformin can be prescribed for diabetic psoriasis patients without safety concerns. PMID: 30779846 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
CONCLUSIONS: GLP-1 impaired keratinocytes inflammatory signals by activating AMPK and restrained macrophage migration. PMID: 30776356 [PubMed - as supplied by publisher]
Source: Experimental and Molecular Pathology - Category: Pathology Authors: Tags: Exp Mol Pathol Source Type: research
The Wheat Belly lifestyle begins with elimination of the worst and most dominant of all grains in the diet, semi-dwarf wheat products, followed by elimination of its closely-related brethren in other grains. This alone is a powerful start in reversing the 200-some diseases of autoimmunity. We now know that the gliadin protein of wheat and related proteins in other grains trigger increased intestinal permeability that initiates the process, as highly inflammatory compounds, such as lipopolysaccharide from bacterial cell walls, are permitted entry into the body. We also know that gliadin itself gains entry into the bloo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune Gliadin gluten-free grain-free grains Inflammation wheat belly Source Type: blogs
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