Atherosclerosis Risk: Psoriasis Stronger Predictor Than Diabetes Atherosclerosis Risk: Psoriasis Stronger Predictor Than Diabetes

Associations between atherosclerosis risk and type 2 diabetes appear primarily driven by weight, whereas risk with psoriasis is independent of known cardiometabolic risk factors.Medscape Medical News
Source: Medscape Dermatology Headlines - Category: Dermatology Tags: Dermatology News Source Type: news

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Researchers here propose that the skin is a significant source of the systemic chronic inflammation that is observed in older individuals. Setting aside the range of other mechanisms that contribute to inflammation to only consider the accumulation of senescent cells with age, and the fact that these errant cells are a potent source of inflammatory signaling, this proposition doesn't seem unreasonable. The skin is a sizable organ, after all, and even if it produces senescent cells at much the same pace as the rest of the body, it will still represent a large and quite distributed pool of such cells, positioned to delivery ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Abstract Topical corticosteroids are widely used to treat inflammatory or pruritic skin conditions. The impact of systemic absorption of topical corticosteroids on the risk of hyperglycemia, and subsequent type 2 diabetes is unclear. Andersen et al. aimed to determine if topical corticosteroid use for psoriasis and eczema,1 which affect 2-3% and 2-8% of adults worldwide, respectively, is associated with an increased risk of newly-diagnosed type 2 diabetes.2,3. PMID: 31883374 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Authors: Dalmády S, Kemény L, Antal M, Gyulai R Abstract Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background and environmental triggers. Patients with psoriasis and psoriatic arthritis are at greater risk of developing other chronic and potentially severe comorbidities, such as psoriatic arthritis, hyperlipidemia, type 2 diabetes mellitus, obesity, metabolic syndrome, cardiovascular diseases or depression. Recently, accumulating epidemiologic, genetic and pathogenetic evidence indicates that psoriasis is also associated with periodontitis, a chronic progressive ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
WEDNESDAY, Dec. 11, 2019 -- Rates of type 2 diabetes may be higher among patients with psoriasis, according to a study published online Dec. 3 in the Journal of the European Academy of Dermatology and Venereology. Wiebke Sondermann, Dr. Med., from...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Abstract As part of a larger cross-sectional, case-control study on cardiometabolic diseases in psoriasis this study investigated the association of visceral fat and serum adipokines with psoriasis and cardiometabolic diseases. A total of 103 patients with psoriasis and 98 controls, matched for body mass index, ethnicity and gender, were recruited over 15 months. Abdominal visceral fat was measured by computerized tomo-graphy. Logistic regression analysis revealed that visceral fat was associated with psoriasis (odds ratio (95% confidence interval): 1.56 (1.15, 2.11)), hyper-triglyceridaemia (1.67 (1.22, 2.28)), l...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
llo Persico Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis,...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Psoriasis is a systemic inflammatory disease characterized by overproliferation of keratinocytes and epidermal thickening resulting from dysregulated immune responses.[1,2] This chronic condition, which affects approximately 1% to 4% of the world ’s population, is often associated with comorbidities, including obesity, type 2 diabetes, hyperlipidemia, hypertension, and cardiovascular disease.[3–7] The pathogenesis of psoriasis involves keratinocyte recruitment of myeloid dendritic cells, which produce interleukin (IL)-23 to activate T he lper 17 (Th17) cells.[2,8,9] Th17 cells, in turn, produce several cytokine...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
This study was conducted to assess prevalence and biological treatment of psoriasis in children and adolescents based on real-world data. This was a non-interventional retrospective analysis of anonymized insurance claims data using an age- and gender-stratified database subset, which contains 4.34 million subjects.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Psoriasis is associated with inflammatory, metabolic and cardiovascular comorbidity. Psoriasis patients show various signs of low-grade systemic inflammation, which may contribute to the development of peripheral insulin resistance, type 2 diabetes and atherosclerosis. High-sensitivity C-reactive protein (hs-CRP) is regarded as a marker that is able to detect low-grade inflammatory processes. In this context, the correlation of certain psoriatic comorbidities and metabolic parameters with hs-CRP at baseline was examined.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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