Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab

Systematic analysis of circulating soluble angiogenesis-associated proteins in ICON7 identifies Tie2 as a biomarker of vascular progression on bevacizumab British Journal of Cancer 115, 228 (12 July 2016). doi:10.1038/bjc.2016.194 Authors: Cong Zhou, Andrew Clamp, Alison Backen, Carlo Berzuini, Andrew Renehan, Rosamonde E Banks, Richard Kaplan, Stefan J Scherer, Gunnar B Kristensen, Eric Pujade-Lauraine, Caroline Dive &Gordon C Jayson
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Tags: ovarian cancer VEGF bevacizumab biomarkers Tie2 Bayesian modelling Source Type: research

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Condition:   Low Anterior Resection Syndrome Intervention:   Other: low anterior resection syndrome evaluation Sponsor:   Medical University of Vienna Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Dai Y, Jin S, Li X, Wang D Abstract [This corrects the article DOI: 10.18632/oncotarget.13817.]. PMID: 32064052 [PubMed - in process]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSIONS: Collectively, serum exosomal miR-484 could serve as a reliable and non-invasive marker for predicting the prognosis of OC. PMID: 32065786 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers - Category: Cancer & Oncology Tags: Cancer Biomark Source Type: research
Molecules, Vol. 25, Pages 964: Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis‐ Inducing Effects on Human Leukemic Cells Molecules doi: 10.3390/molecules25040964 Authors: Koutova Kulhava Havelek Majorosova Královec Habartova Hošťálková Opletal Cahlikova Řezáčová Bersavine is the new bisbenzylisoquinoline alkaloid isolated from the Berberis vulgaris L.(Berberidaceae) plant. The results of cytotoxicity screening 48 h post‐treatment showed thatbersavine considerably inhibits the proliferatio...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Doctors took immature eggs from the French woman's ovaries before artificially maturing them in the lab and freezing them. Years later, the eggs were thawed and fertilised, and the woman had a baby.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
rrini Marina Fabbi We showed that IL-27 shares several effects with IFN-γ in human cancer cells. To identify novel extracellular mediators, potentially involved in epithelial ovarian cancer (EOC) biology, we analyzed the effect of IL-27 or IFN-γ on the secretome of cultured EOC cells by mass-spectrometry (nano-UHPLC-MS/MS). IL-27 and IFN-γ modulate the release of a limited fraction of proteins among those induced in the whole cell. We focused our attention on GBP1, a guanylate-binding protein and GTPase, which mediates several biological activities of IFNs. Cytokine treatment induced GBP...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Ladd Urban Bast Jr Hanash Harnessing the immune response to tumor antigens in the form of autoantibodies, which occurs early during tumor development, has relevance to the detection of cancer at early stages. We conducted an initial screen of antigens associated with an autoantibody response in serous ovarian cancer using recombinant protein arrays. The top 25 recombinants that exhibited increased reactivity with cases compared to controls revealed TP53 and MYC, which are ovarian cancer driver genes, as major network nodes. A mass spectrometry based independent analysis of circulating immunoglobulin (Ig)-b...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Paraneoplastic neurologic syndromes are rare but well described presentation of certain malignancies in both children and adults. Cerebellar dysfunction is a common paraneoplastic presentation and has been previously reported in association with small cell lung cancer, breast cancers, ovarian tumors, renal cell carcinoma, follicular lymphoma, and Hodgkin ’s lymphoma. There are only a handful of case reports with the association of paraneoplastic neurologic presentation with Non-Hodgkin lymphoma including Diffuse Large B-cell Lymphoma (DLBCL).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Condition:   Recurrent Epithelial Ovarian, Fallopian or Peritoneal Carcinoma Interventions:   Drug: Carboplatin;   Drug: Pegylated liposomal doxorubicin (PLD);   Drug: Gemcitabine;   Drug: Paclitaxel;   Drug: Mirvetuximab Soravtansine Sponsor:   AGO Research GmbH Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Women who naturally exhibit lower levels of an enzyme blocked by statins have an estimated 40 per cent lower risk of ovarian cancer, a study by Bristol University found.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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