Sudan: Sudan States Run Short of Antimalarial Medications

[Radio Dabanga]Khartoum -Sudan has run short of free medications for the treatment of malaria since October. All the states in Sudan are short of free medications for the treatment of malaria since October last year, a medical source reported to Radio Dabanga. In particular the five Darfur states are lacking this "first-line treatment".
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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Abstract Analysis of the Amino-peptidase N (APN) protein from Anopheles culicifacies as a vector based Transmission Blocking Vaccines (TBV) target has been considered for malaria vaccine development. Short peptides as potential epitopes for B cells and cytotoxic T cells and/or helper T cells were identified using prediction models provided by NetCTL and IEDB servers. Antigenicity determination, allergenicity, immunogenicity, epitope conservancy analysis, atomic interaction with HLA allele specific structure models and population coverage were investigated in this study. The analysis of the target protein helped to...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Authors: Cheaveau J, Mogollon DC, Mohon MAN, Golassa L, Yewhalaw D, Pillai DR Abstract Introduction: Historically, the global community has focused on the control of symptomatic malaria. However, interest in asymptomatic malaria has been growing, particularly in the context of malaria elimination.Areas Covered: We undertook a comprehensive PubMed literature review on asymptomatic malaria as it relates to detection and elimination with emphasis between 2014-2019. Diagnostic tools with a low limit of detection (LOD) have allowed us to develop a more detailed understanding of asymptomatic malaria and its impact. These...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
With more than half the world now at risk from mosquito-transmitted dengue fever, according to the World Health Organization (WHO), the UN has taken the lead on a global effort to eradicate the disease – and many others – by measuring the impact of releasing millions of sterilized pests across several continents, it announced on Thursday.
Source: UN News Centre - Health, Poverty, Food Security - Category: International Medicine & Public Health Source Type: news
(University of Bern) An international scientific consortium led by the cell biologists Volker Heussler from the University of Bern and Oliver Billker from the Ume å University in Sweden has for the first time systematically investigated the genome of the malaria parasite Plasmodium throughout its life cycle in a large-scale experiment. The researchers were able to identify hundreds of targets that are urgently needed in drug and vaccine development to eradicate the disease.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
On 10 October 2019, the National IHR Focal Point for Sudan notified WHO of 47 suspected cases of Rift Valley Fever (RVF), including two deaths in Arb ’aat Area, Towashan Village, in El Qaneb locality, Red Sea State. The suspected cases presented with high-grade fever, headaches, joint pain, vomiting. There were no hemorrhagic signs or symptoms observed. The first case presented to the health facility on 19 September 2019. On 28 September 2019, a total of 14 samples were sent to the National Public Health Laboratory in Khartoum, and 5 tested positive for RVF by Immunoglobulin M (IgM) enzyme-linked immunosorbent assay ...
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Following publication of the original article [1], the authors flagged an error in Addition file 6.
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Correction Source Type: research
Let’s pretend the 195 nations that signed the 2016 Paris Climate Accord really do take all of the steps necessary to reach the agreement’s key goal: limiting the increase in global temperature to 1.5°C above pre-industrial levels. In that world, any children born today would grow up to witness some happy milestones. If they lived in the United Kingdom, they’d see their country phase out the use of coal by the time they turned six. If they lived in France, they would see gasoline-powered cars eliminated by their 21st birthday. And, as all of the 195 countries similarly reached their individual targets,...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Children climate change embargoed study Environment global warming health Source Type: news
(Deakin University) Researchers have narrowed down the malaria proteins and disease-fighting antibodies that could be used to develop a vaccine against the most severe forms of malaria.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ira Nubia Boechat Based on medicinal chemistry tools, new compounds for malaria treatment were designed. The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine, amodiaquine, mefloquine and sulfadoxine, were used as inspiration. We demonstrated the importance of quinoline and non-quinoline derivatives in vitro with activity against the W2 chloroquine-resistant (CQR) Plasmodium falciparum clone strain and in vivo against Plasmodium berghei-infected mouse model. Among the quinoline derivatives, new hybrids between chloroquine and sulfadoxine were designed, which gave rise to an important proto...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine texts.MethodsIn vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition assay.ResultsMethanolic extracts of Adhatoda zeylanica, Embelia ribes, Piper nigrum and Plumbago zeylanica exhibited more than 50% inhibition in both the stains in schizont maturation inhibition a...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
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