Immune derangement occurs in patients with H7N9 avian influenza

Patients with avian H7N9 virus infection display hyper-activated inflammatory and anti-inflammatory response, which may be associated with the rapid progression and high mortality of this disease.
Source: Critical Care - Category: Intensive Care Authors: Source Type: research

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long Xu Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent studies have suggested that this category of anti-inflammatory drugs could be potentially useful for the control of inflammation “storms” in respiratory virus infections. In addition to their role in regulating immune cell functions, JAK1 and JAK2 have been recently identified as crucial cellular factors involved in influenza A virus (IAV) replication and could be potentially targeted for antiviral therapy. Gingerenone ...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Abstract In January 2020, the subclade of highly pathogenic avian influenza (H5N6) virus infected migratory whooper swans and mute swans in Xinjiang, western China. The virus is lethal to chickens and ducks but has low pathogenicity in mice. Antigenically, this subclade is similar to the H5N1 vaccine seed virus Re-11. PMID: 33030424 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
Abstract An outbreak of low-pathogenicity avian influenza A(H7N3) virus of North American wild bird lineage occurred on commercial turkey farms in North Carolina and South Carolina, USA, during March-April 2020. The virus mutated to the highly pathogenic form in 1 house on 1 farm via recombination with host 28S rRNA. PMID: 33030423 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
Publication date: Available online 30 September 2020Source: Veterinary MicrobiologyAuthor(s): Mengkai Cai, Ruting Zhong, Chenxiao Qin, Zhiqing Yu, Junming Huang, Xiaoyan Wen, Chihai Ji, Yongjie Chen, Yu Cai, Heyou Yi, Lang Gong, Guihong Zhang
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
This study was designed to evaluate the persistence of A/H5 HP AIV in slurry from various duck productions. This was achieved i) in the laboratory setting by artificially spiking four AIV-free slurry samples with known amounts of A/H5N9 HP AIV and monitoring virus infectivity, with or without lime treatment to achieve pH 10 or pH 12, and ii) by sampling slurry tanks on five naturally A/H5N8 HP-contaminated farms. Experimental results in artificially spiked slurry suggested virus survival for 4 weeks in slurry from Muscovy- or Pekin-duck breeders, and for 2 weeks in slurry from ducks for "foie-gras" production dur...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Abstract BACKGROUND AND OBJECTIVES: The high mortality rate of H7N9 strain of avian influenza virus (AIV) infected patients has been a major clinical concern. Iron overload increases the susceptibility of host for several kinds of microbial infection. However, the study on patients' iron and ferritin status associated with clinical outcome of AIVH7N9 virus infection is poorly understood, and in order to explain the linkage we carried out this study. METHODS AND STUDY DESIGN: We retrospectively collected serum from 46 patients infected with H7N9 virus from the hospital in Hangzhou city, Zhejiang province of Ch...
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
AbstractTo date, avian influenza viruses (AIVs) have persisted in domestic poultry in wet markets in East Asian countries. We have performed ongoing virus surveillance in poultry populations in Vietnam since 2011, with the goal of controlling avian influenza. Throughout this study, 110 H3 AIVs were isolated from 2760 swab samples of poultry in markets and duck farms. H3 hemagglutinin (HA) genes of the isolates were phylogenetically classified into eight groups (I –VIII). Genetic diversity was also observed in the other seven gene segments. Groups I–IV also included AIVs from wild waterbirds. The epidemic strain...
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research
Abstract We investigated the experimental infection of two highly pathogenic avian influenza H5N1 viruses isolated from crow (A/crow/Assam/142119/2008) and chicken (A/chicken/Sikkim/151466/2009) in house crows (Corvus splendens). Both viruses caused infection in crows, where four out of six and three out of six crows succumbed to H5N1 infection within 11 days post challenge by crow and chicken viruses, respectively. The major clinical signs in crows were wing paralysis, circling and torticollis. The virus shedding detected from swabs was not persistent in neither crow nor chicken viruses. Both viruses were isolate...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
In this study, 12 AIV isolates of H10–H12 subtypes were identified via routine surveillance of wild birds in Shanghai, China from 2016 to 2019, including two H10, three H11 and seven H12 isolates. Sequence and phylogenetic analyses revealed that the genomic segments of the 12 isolates are highly diverse. These 12 isolates are closely related to those in the Eurasian lineage and share a high degree of sequence identity with those from wild birds and domestic ducks in countries in the East Asian–Australasian Flyway, including Japan, Korea, Bangladesh, Vietnam and China. However, parts of the genomic segme...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
This study provides further insight into the ways that lymphocytes maturate and traffic in response to H7N9 infection in the ferret model.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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