Clinical Significance of Myeloid‐Derived Suppressor Cells in Human Immunodeficiency Virus‐1/ Hepatitis C Virus‐coinfected Patients

Abstract Myeloid‐derived suppressor cells (MDSCs) are known to accumulate during chronic viral infection, including human immunodeficiency virus‐1 (HIV‐1) and hepatitis C virus (HCV) infection, and play a critical role in suppressing immune responses. However, the role of MDSCs in HIV/HCV coinfection is unclear. Here, we observed a dramatic increase in monocytic MDSCs (M‐MDSCs) level in the peripheral blood of HIV/HCV‐coinfected patients compared to that of healthy controls; the level of M‐MDSCs proportion in coinfection was not higher than that in HIV or HCV monoinfection. Interestingly, we found the M‐MDSCs level in coinfected patients correlated well with CD4+ T cell loss (r = −0.5680; P = 0.0058), HIV‐1 load (r = 0.6011; P = 0.0031), HCV load (r = 0.6288; P = 0.0017) and activated CD38+ T cells (r = 0.5139; P = 0.0144). Initiation of highly active antiretroviral therapy considerably reduced both M‐MDSCs and CD8+CD38+‐activated T cell proportion in coinfected patients, and they showed a parallel course of decline. Thus, our results suggest that HIV‐1 infection and high chronic immune activation may contribute to the expansion of M‐MDSCs and accelerate the disease progression in HIV/HCV‐coinfected patients.
Source: Scandinavian Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Human Immunology Source Type: research

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Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Publication date: November 2019Source: European Urology Supplements, Volume 18, Issue 11Author(s): I. Tsimafeyeu, S. Protsenko, R. Gafanov, A. Semenova, A. Oganesyan, N. Nurgaliyev, S. Krasny, A. Bondarenko, S. Safina, K. Zakurdaeva
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Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
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Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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AbstractOver the last decade, genome-wide association studies led to major advances in identifying human genetic variants associated with infectious disease susceptibility. On the pathogen side, comparable methods are now applied to identify disease-modulating pathogen variants. As host and pathogen variants jointly determine disease outcomes, the most recent development has been to explore simultaneously host and pathogen genomes, through so-called genome-to-genome studies. In this review, we provide some background on the development of genome-to-genome analysis and we detail the first wave of studies in this emerging fi...
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Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
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