TERT Promoter Mutations and Their Association with BRAF V600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer.

Conclusions In this large cohort, we found TERT promoter mutations to be common, particularly in FTC and BRAF mutation-positive PTC, and associated with aggressive clinicopathological characteristics. PMID: 24617711 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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Authors: Boukheris H, Bettayeb A, Anderson LA, Achour Z, Benbachir FZ, Attar S, Saim H, Rouigeb K, Berber N Abstract Over the last three decades, the incidence of thyroid cancer has increased worldwide. The reasons for this increase remain controversial. In Algeria, however, to date, information on thyroid cancer has been limited to a hospital-based case series. We analyzed data from a population-based cohort study in Oran District, Algeria, to describe demographic and clinicopathological characteristics of patients diagnosed with thyroid cancer between 1993 and 2013. Medical records and pathology reports of thyroi...
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In this study, we show that18F-DCFPyl might detect neovasculature in advanced, metastatic differentiated thyroid cancer (DTC). We first stained the preserved lymph node samples of three patients with DTC who had undergone total thyroidectomy and neck dissection for cervical lymph node metastatic disease to identify PSMA expression, with the PSMA antibody (DAKO Monoclonal). Then, we performed18F-DCFPyl imaging in two other advanced DTC patients with elevated serum thyroglobulin (Tg), indicative of residual disease. We compared the findings with contemporaneous FDG PET/CT scan, conventional Imaging (CT,MRI) and whole-body sc...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
Chung Tae Hyuk Kim The optimal initial surgical extent for medullary thyroid carcinoma (MTC) remains controversial. Previous studies on serum calcitonin are limited to reporting the calcitonin threshold according to anatomical disease burden. Here, we evaluated whether preoperative calcitonin levels can be used to predict optimal surgical extent. We retrospectively reviewed the 170 patients with MTC at a tertiary Korean hospital from 1994 to 2019. We extracted data on preoperative calcitonin level, primary tumor size and the number and location of lymph node metastases (LNMs). To evaluate disease extent, we divided ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Conclusion: The results can contribute to an optimization of the radiological protection of patients submitted to RIT, as well as allow better logistics of their admission, which can lead to more appropriate accommodation for the patient with a better use of resources. PMID: 33020234 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
Publication date: Available online 7 October 2020Source: MitochondrionAuthor(s): Zhiying Jiang, Tyler Bahr, Chen Zhou, Tao Jin, Hao Chen, Shujie Song, Yuji Ikeno, Liheng Tian, Yidong Bai
Source: Mitochondrion - Category: Biochemistry Source Type: research
Publication date: Available online 7 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Ikram ul Haq Chaudhry, Ahsan Cheema, Chaudhry Aqeel, Ahmed Abbas
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Differentiated thyroid cancer has been treated with radioiodine for almost 80  years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresol...
Source: EJNMMI Physics - Category: Radiology Authors: Tags: Original research Source Type: research
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