Asthma is being overdiagnosed, doctors warn
Inhalers are frequently dispensed for no good reason, leading medics claim
Conclusions: Negative ICS beliefs are associated with higher number of oral steroid courses. The association between CAM endorsement and asthma control is varied, but mostly in favor of improved control. Financial difficulties may make CAM use more likely. PMID: 32646322 [PubMed - as supplied by publisher]
Publication date: Available online 9 July 2020Source: The Lancet Respiratory MedicineAuthor(s): Richard N van Zyl-Smit, Matthias Krüll, Christian Gessner, Yasuhiro Gon, Oliver Noga, Alexia Richard, Amy de los Reyes, Xu Shu, Abhijit Pethe, Ana-Maria Tanase, Peter D'Andrea, PALLADIUM trial investigators
Publication date: Available online 9 July 2020Source: The Lancet Respiratory MedicineAuthor(s): Guy Brusselle
Publication date: Available online 9 July 2020Source: The Lancet Respiratory MedicineAuthor(s): Huib A M Kerstjens, Jorge Maspero, Kenneth R Chapman, Richard N van Zyl-Smit, Motoi Hosoe, Ana-Maria Tanase, Catherine Lavecchia, Abhijit Pethe, Xu Shu, Peter D'Andrea, IRIDIUM trial investigators
Publication date: Available online 9 July 2020Source: The Lancet Respiratory MedicineAuthor(s): J Christian Virchow
In this study, we particularly focused on microRNA cargo of nanovesicles in bronchoalveolar lavage of severe asthmatic patients when compared to healthy controls. We extracted nanovesicle RNA using a serial filtration method. RNA content was analyzed with small RNA sequencing and mapped to pathways affected using WebGestalt 2017 Software. We report that severe asthma patients have deficient loading of microRNAs into their airway luminal nanovesicles and an altered profile of small RNA nanovesicle content (i.e., ribosomal RNA and broken transcripts, etc.).
Conclusions: Our pooled data indicated that IL-13 + 1923 C > T, -1112 C > T and +2044 A > G polymorphisms were correlated with risk of pediatric asthma. PMID: 32643534 [PubMed - as supplied by publisher]
AbstractPurpose of ReviewThe aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients.Recent FindingsOtitis media is a very common infection in general population. The concept of otitis-prone children established a certain frequency of the infections in order to look for conditions leading to them. The confirmation of middle ear impairment by specialists has demonstrated better confiability. The hallmarks f...
Publication date: Available online 9 July 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Gyan Chandra Kashyap, Santosh Kumar Sharma, Shri Kant Singh
Conditions: Asthma; Eosinophilic; COVID; Covid-19 Interventions: Dietary Supplement: Best Standard of Care + CARDIO; Dietary Supplement: Best Standard of Care Sponsors: Hofseth Biocare ASA; KGK Science Inc. Not yet recruiting