Lyme: Fight Harder For Science and End This War

I just had a flashback. When I was diagnosed with Lyme, I knew little about it. I went to the first infectious disease doctor with my bullseye still present, asking lots of questions. Among them, are you sure this three weeks of doxycycline is enough. He smiled, and with his eyes fixed on his computer, he said, "Yes, it's more than enough. In fact, I could just tell you to take ten days but then you'd come back later if anything went haywire and ask why I didn't give you twenty-one." He looked up, "Call me if anything goes crazy." A month later, I called. I woke up with a very sore throat and fever two days before my brother's wedding and a gland in my neck that felt like a pulsating grape. It was movable but scarily large. He said if it didn't go down in a few weeks, to let him know. It didn't, so I called again. He thought I should have it biopsied. I thought I should go see my ear, nose and throat doctor instead, who sent me for an ultrasound but felt it was a remnant of Lyme. The radiologist said it was big, but symmetrical, and not particularly alarming. He also found a few more and said to have my neck rescanned in three months. I want to point out that this symptom is extremely typical of a Lyme co-infection called Bartonella, which of course, I did not know at the time. Is that what the ID doc meant when he said to reach out if anything went crazy? He seemed more than willing to have me get a biopsy of a lymph node that sits on top of my carotid a...
Source: Science - The Huffington Post - Category: Science Source Type: news

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ConclusionsIn this study, we showed TEW-7197 and ramucirumab considerably decreased invasiveness, thus EMTness in a panel of diffuse-type GC cell lines including GC PDCs. Taken together, we confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
This paper reports the design of a high-accuracy spatial location estimation method using ultrasound waves by exploiting the fixed geometry of the transmitters. Assuming an isosceles triangle antenna configuration, where three antennas are placed as the vertices of an isosceles triangle, the spatial location problem can be formulated as a non-convex optimization problem whose interior is shown to admit a Riemannian manifold structure. Our investigation of the geometry of the newly introduced manifold (i.e., the manifold of all isosceles triangles in $mathbb {R}^3$) enables the design of highly efficient optimization algori...
Source: IEEE Transactions on Signal Processing - Category: Biomedical Engineering Source Type: research
This study develops a multi-spatiotemporal compounding CBE (MST-CBE) imaging approach for monitoring specific to CBUS thermal therapy. Methods: Ex vivo thermal ablations were performed with stereotactic positioning of a 180° directional CBUS applicator, temperature monitoring probes, endorectal US probe, and subsequent lesion sectioning and measurement. Five frames of raw radiofrequency data were acquired throughout in 15s intervals. Using window-by-window estimation methods, absolute and positive components of MST-CBE images at each point were obtained by the compounding ratio of squared envelope data within an increa...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Systematically mapping the mechanical properties of skin and tissue is useful for biomechanics research and disease diagnostics. For example, later stage breast cancer and lymphoma manifest themselves as hard nodes under the skin. Currently, mechanical measurements are done manually, with a sense of touch or a handheld tool. Manual measurements do not provide quantitative information and vary depending on the skill of the practitioner. Research shows that tactile sensors could be more sensitive than a hand. We propose a method that uses our previously developed skin-crawling robots to noninvasively test the mechanical prop...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: Mitigation of LVAD sounds from precordial sound recordings of LVAD recipients enables analysis of intrinsic heart sounds. Significance: These findings provide proof-of-concept evidence of the clinical utility of heart sound analysis for bedside and remote monitoring of LVAD recipients.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
This study shows that the LVADs can respond appropriately to changing patient states and physiological demands without the need for additional pressure or flow measurements.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: We propose an experimental setup and deep learning based rupture detection for the complex OCT data in front of the needle tip, even in deeper tissue structures without the need for US or force sensor guiding. Significance: This study promises a suitable approach to complement a robust robotic needle placement.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The performance of our three methods have proved that they can be potentially applied to other ultrasound-based medical imaging studies with unknown distributed positions of sensor array to enhance the imaging quality. Significance: The proposed methods can contribute to precise biomedical imaging with unknown distributed positions of sensor array in different application scenarios.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion: The developed DPLUS makes high-power ultrasound transmission in long and flexible thin waveguide possible. Significance: The concept of DPLUS for delivering high-power ultrasound is powerful in the field of Ultrasonics.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
In this study, we investigated the oscillatory hyperconnectivity and hypoconnectivity networks in MDD under a naturalistic and continuous stimuli condition of music listening. With the assumption that the healthy group and the MDD group share similar brain topology from the same stimuli and also retain individual brain topology for group differences, we applied the coupled nonnegative tensor decomposition algorithm on two adjacency tensors with the dimension of time $times $ frequency $times $ connectivity $times $ subject, and imposed double-coupled constraints on spatial and spectral modes. The music-induced oscillatory ...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - Category: Neuroscience Source Type: research
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