Vitamin D and airway infections: a European perspective

Abstract Vitamin D has immuno-modulatory properties, and deficient levels of circulating 25-hydroxyvitamin D (
Source: European Journal of Medical Research - Category: Research Source Type: research

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Abstract Tuberculosis (TB) kills almost 4,000 people a day and is competing with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) as the most deadly infectious disease in the world. The gold standards of detection and management of latent tuberculosis infection (LTBI) have not been successful in complete eradication of the disease. Current screening modalities of TB include tuberculin skin testing (TST) and/or interferon-γ release assay (IGRA). However, these screening tests have been heavily studied in healthy populations but not in the elderly who are more likely to have multiple...
Source: Clin Med Res - Category: Research Authors: Tags: J Clin Med Res Source Type: research
Modern lifestyle limits our exposure to sunlight, which photosynthesizes vitamin D in the skin, and the incidence of nutritional rickets has been resurging. Vitamin D is one of the oldest hormones; it is photosynthesized in all forms of life from the phytoplankton to mammals. A selective sweep of the promoter of the vitamin D receptor (VDR) happened as soon as Homo sapiens migrated out of Africa; it co-adapted with skin color genes to provide a fine-scale adaptation to latitudes and the levels of exposure to ultraviolet (UV)B radiation along the route out of Africa. Exposure to UVB radiation balances the need for vitamin D...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conditions:   Thalassemia;   Tuberculosis;   Vitamin D Deficiency Intervention:   Dietary Supplement: Cholecalciferol supplementation Sponsors:   Universitas Padjadjaran;   Hasan Sadikin General Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions Decrease in cholesterol efflux, increase in uptake, and excess esterification of cholesterol compounded by the action of lipid peroxidation products generated by inflammatory processes contribute to foam cell formation in atherosclerosis. Since these are critical events in the pathogenesis of atherosclerosis, they have been extensively studied. On the contrary, although a role for host lipid metabolism in mycobacterial pathogenesis has been established, research in the different components that contribute to the alteration in host lipid metabolism and cholesterol homeostasis is still in the nascent stages. The...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Izabella Pereira da Silva Bezerra1†, Gabriel Oliveira-Silva1†, Danielle Sophia Ferreira Santos Braga1, Mirian França de Mello1, Juliana Elena Silveira Pratti1, Joyce Carvalho Pereira1, Alessandra Marcia da Fonseca-Martins1, Luan Firmino-Cruz1, Diogo Maciel-Oliveira1, Tadeu Diniz Ramos1, André Macedo Vale1, Daniel Claudio Oliveira Gomes2, Bartira Rossi-Bergmann1 and Herbert Leonel de Matos Guedes1,3* 1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 2Núcleo de Doenças Infecciosas/Núcleo de Biotecnologia,...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 3 April 2019Source: Microbial PathogenesisAuthor(s): María Elvira Balcells, Noemí Yokobori, Bo-young Hong, John Corbett, Jorge CervantesAbstractMycobacterium tuberculosis (Mtb) has the extraordinary ability to persist for decades within within granulomas in the human host. This histopathological structures involved in both protection and pathogenesis, are subject to various influences from the host systemically and through micro-niche environments. Despite the fact that vitamin D (VD) has a key role in macrophage activation and mycobacterial clearance in the early stages of ...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
The Wheat Belly lifestyle begins with elimination of the worst and most dominant of all grains in the diet, semi-dwarf wheat products, followed by elimination of its closely-related brethren in other grains. This alone is a powerful start in reversing the 200-some diseases of autoimmunity. We now know that the gliadin protein of wheat and related proteins in other grains trigger increased intestinal permeability that initiates the process, as highly inflammatory compounds, such as lipopolysaccharide from bacterial cell walls, are permitted entry into the body. We also know that gliadin itself gains entry into the bloo...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune Gliadin gluten-free grain-free grains Inflammation wheat belly Source Type: blogs
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