FDA outlines standards for anti-abuse generic painkillers

WASHINGTON (AP) — Federal officials are encouraging generic drugmakers to reformulate their painkillers to make them harder to abuse, the latest in a string of steps designed to combat abuse of highly-addictive prescription pain drugs.
Source: U.S. News - Health - Category: Consumer Health News Source Type: news

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AbstractOpioid overdose accounted for more than 47,000 deaths in the United States in 2018. The risk of new persistent opioid use following breast cancer surgery is significant, with up to 10% of patients continuing to fill opioid prescriptions one year after surgery. Over prescription of opioids is far too common. A recent study suggested that up to 80% of patients receiving a prescription for opioids post-operatively do not need them (either do not fill the prescription or do not use the medication). In order to address this important issue, The American Society of Breast Surgeons empaneled an inter-disciplinary committe...
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
(University of Arizona Health Sciences) When people think of opioid addiction, they don't think of pregnant women. Opioid addiction during pregnancy, however, increased 500% in the past 15 years. Alicia Allen, PhD, MPH, a University of Arizona assistant professor affiliated with the Comprehensive Pain and Addiction Center, seeks to understand the relationship between postpartum hormones and opioid relapse to support women in recovery. For that, Dr. Allen recently won a five-year, $2.3 million National Institutes of Health New Innovator Award.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(University of Illinois at Chicago) Researchers at the University of Illinois Chicago will lead a $7.1 million, five-year national study to determine the effectiveness of acupuncture and guided relaxation for people with chronic pain from sickle cell disease. The National Institutes of Health grant is part of its Helping to End Addiction Long-term Initiative. The initiative aims to improve prevention and treatment strategies for opioid misuse and addiction and to enhance pain management.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Despite advances in the understanding of pain physiology there has been a paucity of novel analgesic medications developed to address the still high unmet need of pain patients especially those who rely on addictive opioid medicines for pain relief. The successful development of novel non-opioid, non-addictive therapeutics requires advances in preclinical target validation that demonstrate sufficient human disease relevance to trigger investment in non-clinical development and subsequent clinical trials to obtain proof of biology and early proof of efficacy before registrational studies. Translating novel target discoverie...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Despite advances in the understanding of pain physiology there has been a paucity of novel analgesic medications developed to address the still high unmet need of pain patients especially those who rely on addictive opioid medicines for pain relief. The successful development of novel non-opioid, non-addictive therapeutics requires advances in preclinical target validation that demonstrate sufficient human disease relevance to trigger investment in non-clinical development and subsequent clinical trials to obtain proof of biology and early proof of efficacy before registrational studies. Translating novel target discoverie...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
In this study, we have built a comprehensive map of alternative splicing events that produce 6TM receptor variants in all the OPRs and demonstrated their evolutionary conservation. We then obtained evidence for their translation through ribosomal footprint analysis. We discovered that N-terminally truncated 6TM GPCRs are rare in the human genome and OPRs are overrepresented in this group. Finally, we also observed a significant enrichment of 6TM GPCR genes among genes associated with pain, psychiatric disorders, and addiction. Understanding the biology of 6TM receptors and leveraging this knowledge for drug development sho...
Source: Cellular and Molecular Neurobiology - Category: Cytology Authors: Tags: Cell Mol Neurobiol Source Type: research
Abstract BACKGROUND: Opioids are effective analgesics in the management of chronic pain. However, their clinical use is hindered by adverse side effects such as addiction and analgesic tolerance. Naringenin is a common polyphenolic constituent of the citrus fruits and is one of the most commonly consumed flavonoids within our regular diet. However, its influences on opioid tolerance and addiction have not yet been clarified. OBJECTIVES: To examine the effect of different doses of naringenin on analgesic tolerance, conditioned place preference and neuroinflammation in morphine-exposed rats. METHODS: Analg...
Source: The American Journal of Drug and Alcohol Abuse - Category: Addiction Authors: Tags: Am J Drug Alcohol Abuse Source Type: research
Digital media&downloads Pain Relief Caused by SARS-CoV-2 Infection May Help Explain COVID-19 Spread New research shows SARS-CoV-2 promotes pain relief when it infects cells through a common protein receptor, neuropilin-1. The finding gives scientists a novel target for non-opioid pain therapeutics, while also offering an explanation for the unrelenting spread of COVID-19. Stacy Pigott Today University of Arizona Health SciencesKhanna_Raj_klh3067.jpg Doctoral student Lisa Boinon prepares buffers while Rajesh Khanna looks on. (Photo: Kris Hanning/University of Arizona Health Sciences)HealthCollege of Medicine - Tuc...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Opioids prescribed for postoperative pain contribute to opioid addiction and abuse. Rural patients are disproportionately affected by this opioid epidemic. The purpose of this study was to understand rural patients ’ perspectives on factors contributing to opioid misuse after operations and barriers to disposal of leftover medication.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: General surgery Source Type: research
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