Hypoxia Promotes Invasion of Endometrial Stromal Cells via Hypoxia-Inducible Factor 1{alpha} Upregulation-Mediated {beta}-Catenin Activation in Endometriosis

Endometriosis is a common benign gynecological disease defined as the presence of endometrial tissue outside the uterine cavity. The aim of this study was to identify the molecular mechanism underlying hypoxia-induced increases in invasive ability of human endometrial stromal cells (HESCs). Herein, we show that the expression levels of hypoxia-inducible factor lα (HIF-1α) and β-catenin were greater in ectopic endometriotic tissue compared with eutopic tissue from controls. Exposure of eutopic endometrial stromal cells under hypoxic conditions or treated with desferrioxamine (DFO, chemical hypoxia) resulted in a time-dependent increase in β-catenin expression and its dephosphorylation. Hypoxia/HIF-1α also activated the β-catenin/T-cell factor (TCF) signaling pathway and the expression of target genes, vascular endothelial growth factor and matrix metalloproteinase 9, and knockdown of HIF-1α or β-catenin abrogated hypoxia-induced increases in HESC invasiveness. These results suggest that HIF-1α interacting with β-catenin/TCF signaling pathway, which is activated by hypoxia, may provide new insights into the etiology of endometriosis.
Source: Reproductive Sciences - Category: Reproduction Medicine Authors: Tags: Original Articles Source Type: research

Related Links:

CONCLUSION: The diagnosis of AWE should be confirmed with imaging of the lesion number, location, size and features before HIFU ablation. HIFU should be the first choice for the treatment of AWE as it is a non-invasive method, with high efficiency and safety and rapid postoperative recovery. PMID: 30428731 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
CONCLUSION: The uterus of postmenopausal woman undergo major morphological changes (mainly atrophic lesions in the endometrium and myometrium), leading to a decline in their morphometric parameters over time from the last menstruation. Localization and number of cells showing the expression of steroid receptors: ER-α, PR, and AR in the uterus of postmenopausal women, depending on the time interval from the last menstruation. PMID: 30426467 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Conditions:   Uterine Fibroid;   Endometriosis Intervention:   Sponsor:   Myovant Sciences GmbH Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Endometriosis Intervention:   Other: The Endometriosis Health Profile EPH-30 Sponsor:   V.K.V. American Hospital, Istanbul Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Endometriosis Interventions:   Procedure: longitudinal suture;   Procedure: transverse suture;   Procedure: Removal of vaginal endometriotic nodule Sponsor:   Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Endometriosis Intervention:   Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 16 November 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Ticiana A.A. Mira, Paulo C. Giraldo, Daniela A. Yela, Cristina L. Benetti-Pinto
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
While endometriosis is recognized to have a high patient burden for adults, the level of morbidity it causes for adolescents has been understudied, and may be minimized by clinicians. The purpose of this study was to determine whether endometriosis has a significant impact on quality of life (QOL) for adolescents and young adults.
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Original article Source Type: research
ConclusionCD33+CD14+CD11b+HLA ‐DR− M ‐MDSCs recruited and activated by CCR9/CCL25 play a crucial role in the pathogenic progression of endometriosis, thus providing a potential target for EM treatment.
Source: American Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Diagnostic Cytopathology, EarlyView.
Source: Diagnostic Cytopathology - Category: Pathology Authors: Tags: LETTER TO THE EDITOR Source Type: research
More News: Chemistry | Endometriosis | Genetics | Reproduction Medicine | Study