Different Expression of Hypoxic and Angiogenic Factors in Human Endometriotic Lesions

Endometriosis is associated with local angiogenic and hypoxic mechanisms. Indeed, peritoneal fluid of women with endometriosis generates a specific microenvironment to support the growth and development of ectopic endometrial tissues. The association between proangiogenic markers and hypoxic processes in different endometriosis phenotypes was investigated in the present study, analyzing the expression of several genes, related to hypoxic signaling pathway and involved in angiogenic processes, in nonpregnant women with different forms of endometriosis. Samples of ovarian endometrioma (OMA; n = 16) or deep infiltrating endometriosis (DIE; n = 11) were collected, and in addition, control endometrium was collected from healthy women by hysteroscopy. The gene expression of the hypoxia-inducible factors (HIF) 1/2α, protease-activated receptors (PARs) 1/4, and vascular endothelial growth factor (VEGF) A was evaluated by quantitative reverse-transcription polymerase chain reaction. Ovarian endometrioma expresses high levels of HIF-1/2α, PAR-1/4, and VEGF-A, while DIE did not show significantly different gene expression compared to endometrium from unaffected women. A positive correlation between the expression of HIF-1/2α and VEGF-A mRNA was observed in OMA. The overall data point out that the heterogeneity of the disease reflects differences in expression levels of genes associated with hypoxia and angiogenesis, suggesting that such conditions may have an active ro...
Source: Reproductive Sciences - Category: Reproduction Medicine Authors: Tags: Original Articles Source Type: research

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ConclusionCurettage for miscarriage or undesired pregnancy is not exempt from complications (as hemorrhage, simple perforation, or infection) Intrauterine fallopian tube incarceration is uncommon but can affect fertility. This diagnosis is important to avoid destruction of the fimbriae, necrosis of the tube and also to reduce the risk for ectopic pregnancy.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 28 August 2018Source: Journal of Minimally Invasive GynecologyAuthor(s): Nancy T. Nguyen, Maqdooda Merchant, Miranda L. Ritterman Weintraub, Chelsea Salyer, Joanna Poceta, Lucero Diaz, Eve F. ZaritskyAbstractStudy objective: To investigate rates of utilization of alternative treatments before hysterectomy for benign gynecologic indications within a large integrated health care system.Design: (Study Design Classification II-2) Retrospective cohort study of patients who underwent hysterectomies for benign gynecologic conditions between 2012 and 2014. From an eligible cohort of 6,892 hystere...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions: The infertile patients with endometriosis had a higher prevalence of endometrial polyps, and those polyps are often combined with simple hyperplasia.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
CONCLUSIONS: Metabolomics analysis of the eutopic endometrium in endometriosis was effectively characterized by UHPLC-ESI-HRMS-based metabolomics. Our study supports the importance of purine and amino acid metabolites in the pathophysiology of endometriosis and provides potential biomarkers for semi-invasive diagnosis of early-stage endometriosis. PMID: 29712562 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
Rationale: During the surgical procedure, endometrial cells can be seeded into the wound edge of the uterine wall, developing into scar endometriosis. Due to the extremely low incidence, estimation of its prevalence is still unavailable. Even rarer might be the scar endometriosis in uterine cavity, to our best knowledge, a situation has not been reported yet. Patient concerns: A 37-year-old woman complained of heavier and prolonged menstruation as well as pelvic pain during menses for more than 4 months. An endometrial cyst in diameter of 6 cm in uterine cavity was revealed by transvaginal ultrasound. Her surgical h...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
I received this tearful email from a patient.I have a very sad medical history .  I used to get extremely painful periods (I got my first periods at the age of around 14-15 years) where medical help was always required by me. The doctors in my home town could not understand the problem and we were completely relying on the best doctors of our city. I was treated for depression, epilepsy, abdominal TB, hormones, etc. etc. because they believed that my symptoms were similar to any of these ailments.After years of treatment but no relief (around 11 years of treatment with no solid diagnosis, no reports nothing), I got ma...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Conclusions An increased expression of pro-inflammatory type 1 cytokines was demonstrated in the endometrium from endometriosic patients, suggesting an endometrial environment harmful for implantation due to the prevalence of Th1 related immunity. An increased expression of TSG-6 was also demonstrated for the first time. Our findings concur to better define the inflammatory imbalance and the abnormal endometrial receptivity, reported in literature, of the eutopic endometrium of women affected by endometriosis.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusion Laparoscopic resection of the blind endometrial cavity in patients who refuse vaginal surgery is a safe and effective treatment alternative.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
To evaluate the association between endometriosis end chronic endometritis (CE) diagnosed by hysteroscopy, conventional histology, and immunohistochemistry.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
I’m a black woman with uterine fibroids. These noncancerous growths, also called intramural fibroids, line the muscular wall of my uterus. Technically benign, they threaten to grow into larger, painful masses that could ultimately rob me of the ability to bear children. Fibroids are common in all women, but research suggests that African American women are significantly more likely to develop uterine fibroids. In fact, in addition to a family history of fibroids, being African American is at the top of the list of causes for the condition. And black women aren’t only at a higher risk for developing fibroids. Th...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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