Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes

This study describes the differences in methylation patterns of HOXA10 gene in uterine myomas, endometriosis, uterine septum, Asherman syndrome, or uterine polyps of women undergoing hysteroscopic surgery. In the endometrium of uteri with polyps, submucosal myomas, and intramural myomas, there were CpG sites within the HOXA10 gene that were highly methylated compared to controls. The HOXA10 gene in women with endometriosis was hypomethylated compared to controls. DNA methylation may be a common molecular mechanism that results in reproductive dysfunction seen in gynecologic disease.
Source: Reproductive Sciences - Category: Reproduction Medicine Authors: Tags: Original Articles Source Type: research

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CONCLUSION: The uterus of postmenopausal woman undergo major morphological changes (mainly atrophic lesions in the endometrium and myometrium), leading to a decline in their morphometric parameters over time from the last menstruation. Localization and number of cells showing the expression of steroid receptors: ER-α, PR, and AR in the uterus of postmenopausal women, depending on the time interval from the last menstruation. PMID: 30426467 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Publication date: September–October 2018Source: Journal of Minimally Invasive Gynecology, Volume 25, Issue 6Author(s): Meagan S. Cramer, Jordan S. Klebanoff, Matthew K. HoffmanAbstractStudy ObjectiveTo determine whether pain, as part of an indication for global endometrial ablation, is an independent risk factor for failure.DesignRetrospective cohort study (Canadian Task Force classification II-2).SettingAcademic-affiliated community hospital.PatientsWomen undergoing global endometrial ablation with radiofrequency ablation (RFA), hydrothermablation (HTA), or uterine balloon ablation (UBA) between January 2003 and Dec...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
This study was performed on 168 infertile women referred to Ahvaz infertility center who were divided into two groups of infertile patients with cervical stenosis (n = 84) and the control group of infertile patients without cervical stenosis (n = 84). Demographic and clinical data of all individuals including age, body mass index (BMI), the duration of infertility, causes of infertility, history of medicine and surgical treatment, endometriosis, type of ovarian cyst, the presence of cervical myomas, polyps, and uterine septum (diagnosed by sonohysterography) were determined. Correlation between internal cervical os...
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Conclusions: The infertile patients with endometriosis had a higher prevalence of endometrial polyps, and those polyps are often combined with simple hyperplasia.Gynecol Obstet Invest
Source: Gynecologic and Obstetric Investigation - Category: OBGYN Source Type: research
ine W Abstract Infertility is a disease characterized by the failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse. It is estimated to affect between 8 and 12% of reproductive-aged couples worldwide. Males are found to be solely responsible for 20-30% of infertility cases but contribute to 50% of cases overall. Secondary infertility is the most common form of female infertility around the globe, often due to reproductive tract infections. The three major factors influencing the spontaneous probability of conception are the time of unwanted non-conception, the age...
Source: Clinical Biochemistry - Category: Biochemistry Authors: Tags: Clin Biochem Source Type: research
Conclusion Findings of this study can help improve clinical and therapeutic management of female infertility related to cervical stenosis and other female infertility risk factors such as duration of infertility.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
CONCLUSION: Although all of the appendectomy samples were normal macroscopically, data from this study suggest that all specimens should be sent for routine investigation. KEY WORDS: Appendicitis, Appendectomy, Carcinoid, Mucocele, Endometriosis. PMID: 29339597 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Funding Opportunity RFA-HD-19-013 from the NIH Guide for Grants and Contracts. The purpose of the Funding Opportunity Announcement (FOA) is to encourage research into the role of pluripotent progenitor/stem cells in the pathogenesis and treatment of selected gynecologic disorders, specifically uterine fibroids, endometriosis, adenomyosis, endometrial polyps, and pelvic organ prolapse.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Conclusion This case illustrates a presentation of endometriosis in a postmenopausal woman mimicking advanced mullerian malignancy. The patient's estrogenic state from obesity in combination with the agonist action of the tamoxifen likely contributed to her rare presentation. While findings such as a thickened endometrial stripe are typical of tamoxifen use, such widespread proliferation of endometriosis resulting in a pelvic mass, genito-urinary obstruction, and plaque-like pelvic spread are not. Précis Endometriosis is a benign estrogen dependent condition rarely problematic in a postmenopausal patient. Tamoxifen ...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
AbstractAdenomyosis is defined as the presence of ectopic endometrial glands and stroma within the myometrium. It is a disease of the inner myometrium and results from infiltration of the basal endometrium into the underlying myometrium. Transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) are the main radiologic tools for this condition. A thickness of the junctional zone of at least 12  mm is the most frequent MRI criterion in establishing the presence of adenomyosis. Adenomyosis can appear as a diffuse or focal form. Adenomyosis is often associated with hormone-dependent lesions such as leiomyom...
Source: Insights into Imaging - Category: Radiology Source Type: research
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