Statins as Targeted "Magical Pills" for the Conservative Treatment of Endometriosis: May Potential Adverse Effects on Female Fertility Represent the "Dark Side of the Same Coin"? A Systematic Review of Literature

The aim of the study was to analyze all the available evidence from both in vitro and in vivo studies regarding the efficacy of statin therapy in the treatment of endometriosis, evaluating the potential efficacy, side effects, and contraindications of their administration in humans. We focused on defining the potential benefits that the administration of statins may have on patients affected by endometriosis and the possible adverse effects of such a therapy on ovarian function and fertility profile. According to our article selection criteria, we included in the review in vitro and in vivo studies performed on human or animal models. The systematic review of literature identified 24 eligible articles, 12 of which reported evidence regarding the effects of statins on endometrial/endometriotic cells and 12 regarding their effects on ovarian function and fertility. All articles seem to emphasize the utility of statin administration in the treatment of endometriosis due to their anti-proliferative/proapoptotic effects, their ability to reduce cell viability and migration, and the inhibition of angiogenesis and anti-inflammatory activities. Regarding the potential adverse effects on gonadal activities, steroidogenesis and fertility function, no conclusive data were collected in human models (excluding women affected by polycystic ovary syndrome in which significant decline of androgen levels was reported after statin treatment), while contrasting results were reported by studies ...
Source: Reproductive Sciences - Category: Reproduction Medicine Authors: Tags: Reviews Source Type: research

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(Florida Atlantic University) 'Is amyloid precursor protein the mastermind behind Alzheimer's or is it just an accomplice?' Researchers devised a multi-functional reporter for amyloid precursor protein and tracked its localization and mobility, noticing a strange association between the protein and cholesterol that resides in the cell membrane of synapses. With cholesterol's broad involvement in almost all aspects of neurons' life, they propose a new theory on the amyloid precursor protein connection in AD, especially in the surface of those tiny synapses, which triggers neurodegeneration.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
(CNN) — Whether you eat breakfast might be linked with your risk of dying early from cardiovascular disease, according to a new study. Skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death, in the study published in the Journal of the American College of Cardiology on Monday. After a person’s age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87% higher risk of cardiovascular mortality compared with people who h...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Heart Disease Source Type: news
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Heart Cholesterol Deaths (Fatalities) Stroke Journal of the American College of Cardiology Source Type: news
In patients with type 2 diabetes and hyperlipidemia or mixed dyslipidemia on a maximally tolerated statin, treatment with evolocumab lowers low-density-lipoprotein cholesterol (LDL-C) and improves levels of other lipids, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Publication date: Available online 21 April 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Stephanie Andrade, Maria J. Ramalho, Joana A. Loureiro, Maria Carmo PereiraAbstractNatural compounds such as caffeine (CA), gallic acid (GA) and tannic acid (TA) have been reported to be useful for Alzheimer’s disease (AD) therapy. It was proved that some natural compounds inhibit the formation of senil plaques composed by beta-amyloid peptide (A β ), a hallmark of AD. Evidences suggest that the therapeutic activity of compounds depends of their interaction with biological membranes. To understand why these c...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Like more than half of older men, I take a cholesterol-lowering medication called a statin. Sometimes that seems a bit strange, because I don ’t have high cholesterol. My doctor prescribed it based on a formula that largely hinges on age and sex. I’m 71 and male. Those two factors alone put me in the high-risk category for […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Cardiology Source Type: blogs
Ghee is a type of clarified butter used in the cuisines of India and the Middle East. Traditionally, it’s made by gently heating cow’s-milk butter until its water content evaporates and its milk solids can be skimmed and strained away, leaving behind only the liquid fat. “Clarified butter is very similar [to ghee], but it’s sometimes made using high heat, whereas ghee is simmered at 100 degrees or less,” says Chandradhar Dwivedi, a distinguished professor emeritus of pharmacology at South Dakota State University. While ghee takes longer to make than some other types of clarified butter, it ret...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition Source Type: news
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Source: Complementary Therapies in Clinical Practice - Category: Complementary Medicine Authors: Tags: Complement Ther Clin Pract Source Type: research
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Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
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Source: NYT Health - Category: Consumer Health News Authors: Tags: Eggs Cholesterol Diet and Nutrition Cooking and Cookbooks Heart Source Type: news
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