Relapse to drug and alcohol use: a matter of sensitization.

Relapse to drug and alcohol use: a matter of sensitization. Acta Neuropsychiatr. 2000 Mar;12(1):5-8 Authors: Schoffelmeer AN, Vanderschuren LJ, Mulder AH, Jacobs EH, Vries TJ Abstract Repeated exposure of rats to cocaine, amphetamine, opiates, nicotine and alcohol causes a very long-lasting (months) increase in the behavioral effects of these addictive drugs and drug-associated environmental stimuli (sensitization). This hypersensitivity is associated with persistent changes in the reactivity of neurons of the motivational (mesocorticolim-bic) system in the brain. Using an animal model for relapse, recent studies in our laboratory show that relapse to drug-seeking behavior (following extinction of intravenous cocaine or heroin self-administration) depends on the occurrence of sensitization. Accordingly, sensitization and conditioning seem to be more important for the persistence of drug and alcohol addiction then the occurrence of withdrawal phenomena. Biochemical research on the molecular and cellular basis of behavioral sensitization and behavioral studies on readjustment of stimulus responsiveness in rats, is of great importance for the development of an adequate pharmacotherapy of addiction. PMID: 26976679 [PubMed]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

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CONCLUSIONS: MAP shows promise assisting in the reduction of substance use early in treatment when vulnerability and risk for relapse is high and has a positive impact on serious problems undercutting addiction treatment efficacy. PMID: 33028480 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
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We examined the indirect effect of distress tolerance on alcohol use and problems via drinking ‐to‐cope motives within a national sample of young adults (N = 297). Analyses suggested coping motives mediated the relationship between distress tolerance and drinking.
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Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery change Patience Stability Source Type: blogs
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Drug and alcohol support workers ​in the North West are on the last day of a 10-day strike today (Friday), as they continue their fight to force their employer, national charity We Are With You​​ (formerly Addaction), to give them a promised pay rise. ​The industrial action involves 30 rehabilitation staff from Wigan and Leigh in Greater Manchester. Yesterday, an ad van visited the Foundry Chambers and Gray’s Inn in London in order to get the message across to Lord Carlile, the Chair of We Are With You’s board of trustees. It then went on to We Are With You’s headquarters ...
Source: UNISON Health care news - Category: UK Health Authors: Tags: Article News Addaction Industrial action North West We Are With You Source Type: news
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