Relapse to drug and alcohol use: a matter of sensitization.

Relapse to drug and alcohol use: a matter of sensitization. Acta Neuropsychiatr. 2000 Mar;12(1):5-8 Authors: Schoffelmeer AN, Vanderschuren LJ, Mulder AH, Jacobs EH, Vries TJ Abstract Repeated exposure of rats to cocaine, amphetamine, opiates, nicotine and alcohol causes a very long-lasting (months) increase in the behavioral effects of these addictive drugs and drug-associated environmental stimuli (sensitization). This hypersensitivity is associated with persistent changes in the reactivity of neurons of the motivational (mesocorticolim-bic) system in the brain. Using an animal model for relapse, recent studies in our laboratory show that relapse to drug-seeking behavior (following extinction of intravenous cocaine or heroin self-administration) depends on the occurrence of sensitization. Accordingly, sensitization and conditioning seem to be more important for the persistence of drug and alcohol addiction then the occurrence of withdrawal phenomena. Biochemical research on the molecular and cellular basis of behavioral sensitization and behavioral studies on readjustment of stimulus responsiveness in rats, is of great importance for the development of an adequate pharmacotherapy of addiction. PMID: 26976679 [PubMed]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Related Links:

CONCLUSIONS: MAP shows promise assisting in the reduction of substance use early in treatment when vulnerability and risk for relapse is high and has a positive impact on serious problems undercutting addiction treatment efficacy. PMID: 33028480 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
Source: Journal of Addictive Diseases - Category: Addiction Authors: Source Type: research
Chronic alcohol consumption is associated with neuroinflammation, neuronal damage, and behavioral alterations including addiction. Alcohol-induced neuroinflammation is characterized by increased expression of ...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
We examined the indirect effect of distress tolerance on alcohol use and problems via drinking ‐to‐cope motives within a national sample of young adults (N = 297). Analyses suggested coping motives mediated the relationship between distress tolerance and drinking.
Source: Journal of Addictions and Offender Counseling - Category: Criminology Authors: Tags: Article Source Type: research
Intimate partners of people with addictions experience significant strain, which coping and social support may reduce. They are also at increased risk for intimate partner violence (IPV: violence/abuse and coercive control), but IPV's effects on coping and...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
AbstractPurpose of ReviewEffective treatment of alcohol and drug disorders in young people is critical to reducing substance-related harm; however, research examining treatment for young people often trails the adult literature. This review identifies 10 evidence-based treatment and service delivery principles that can be applied to treatment settings for young people.Recent FindingsScreening and brief intervention is effective across a range of settings. Incorporating peer networks in service delivery can improve treatment engagement and outcomes, and a harm reduction approach may be beneficial. Treatment outcomes are imp...
Source: Current Addiction Reports - Category: Addiction Source Type: research
Achieving and maintaining sobriety from drugs and alcohol is a lifelong process....The postThe Stages of Change: How Patience Builds Lasting Recovery appeared first onCliffside Malibu.
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery change Patience Stability Source Type: blogs
ConclusionTransient 5-HT inhibition at adolescence may act, in females, as a protective factor for the emergence of anxiety disorders and problematic use of alcohol during adolescence.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Drug and alcohol support workers ​in the North West are on the last day of a 10-day strike today (Friday), as they continue their fight to force their employer, national charity We Are With You​​ (formerly Addaction), to give them a promised pay rise. ​The industrial action involves 30 rehabilitation staff from Wigan and Leigh in Greater Manchester. Yesterday, an ad van visited the Foundry Chambers and Gray’s Inn in London in order to get the message across to Lord Carlile, the Chair of We Are With You’s board of trustees. It then went on to We Are With You’s headquarters ...
Source: UNISON Health care news - Category: UK Health Authors: Tags: Article News Addaction Industrial action North West We Are With You Source Type: news
CONCLUSION: An immediate access to independent housing and support from a mental health team resulted in decreased inpatient days, higher housing stability and cost savings in homeless persons with SCZ or BP disorders. PMID: 32996442 [PubMed - in process]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
More News: Addiction | Alcoholism | Amphetamine | Brain | Environmental Health | Laboratory Medicine | Neurology | Nicotine | Psychiatry | Study