Statins reduce spirochetal burden and modulate immune responses in the C3H/HeN mouse model of Lyme disease

Publication date: Available online 16 March 2016 Source:Microbes and Infection Author(s): Tricia A. Van Laar, Camaron Hole, S.L. Rajasekhar Karna, Christine L. Miller, Robert Reddick, Floyd L. Wormley, J. Seshu Lyme disease (LD) is a systemic disorder caused by Borrelia burgdorferi. Lyme spirochetes encode for a functional 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR EC 1.1.1.88) serving as a rate limiting enzyme of the mevalonate pathway that contribute to components critical for cell wall biogenesis. Statins have been shown to inhibit B. burgdorferi in vitro. Using a mouse model of Lyme disease, we found that statins contribute to reducing bacterial burden and altering the murine immune response to favor clearance of spirochetes.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research

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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Current Psychology - Category: Psychiatry & Psychology Authors: Source Type: research
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Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
This article is protected by copyright. All rights reserved. The presence of cholesterol glycolipids in the membranes of Borrelia burgdorferi was detected and characterized by biophysical and biochemical approaches.  Cholesterol glycolipids are present in both the outer and inner membranes, but are different in composition and their ability to form lipid rafts and in their associated proteins.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research
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Source: Biophysical Journal - Category: Physics Authors: Tags: Biophys J Source Type: research
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Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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Source: Journal of Structural Biology - Category: Biology Source Type: research
This study provides the first analysis of a prokaryotic lipid raft and has relevance for the biology of Borrelia, other pathogenic bacteria, as well as for the evolution of these structures. This article is protected by copyright. All rights reserved
Source: Proteomics - Category: Biochemistry Authors: Tags: Research Article Source Type: research
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