The direct and indirect costs associated with endometriosis: a systematic literature review

This study was funded by AbbVie, which also develops the oral GnRH antagonist elagolix (in collaboration with Neurocrine Biosciences) for the management of endometriosis and uterine fibroids. A.M.S. is an employee of AbbVie and currently owns AbbVie stocks. H.Y., E.X.D. and C.K. are employees of Analysis Group, Inc., which has received consultancy fees from AbbVie. C.W. is a Clinical Professor at the Department Obstetrics and Gynecology at Georgetown University in Washington, DC, USA and has served in a consulting role to AbbVie for this project.
Source: Human Reproduction - Category: Reproduction Medicine Authors: Tags: Gynaecology Source Type: research

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Publication date: Available online 20 April 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Tianjiao Pei, Xin Huang, Ying Long, Changling Duan, Tingting Liu, Yujing Li, Wei HuangAbstractBasic research has shown that signal pathways play significant roles in the development and progression of endometriosis (EMS). We first reported that the Hippo-YAP (Yes-associated protein) pathway promotes cell proliferation and anti-apoptosis in endometrial stromal cells (ESCs) of EMS. Cell autophagy has been found to be involved in the endometrial regulation and the pathophysiology of EMS. We speculated that there may be an el...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
K, Peters M PMID: 31004479 [PubMed - as supplied by publisher]
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
One of 2 new first-of-kind studies on HPV and infertility suggests that high-risk HPV may ascend to infect the upper genital tract, causing endometriosis and affecting fertility.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Women ' s Health Source Type: news
Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively progr...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionMinimal preoperative factors are associated with nonresponse for women having surgery for endometriosis. The severity of pain experienced by women with endometriosis may be used to predict their response to surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
The women’s health technology or so-called femtech market has been on the rise for the last couple of years, but it has mainly revolved around fertility and pregnancy. We believe that female health topics reach far beyond such traditional issues and players should concentrate more on menopause, endometriosis, or mental health, just to name a few areas. Thus, we tried to collect companies which are on top of their game in the conventional fertility and/or pregnancy area, but also start-ups and ventures who are looking way beyond that. Here’s our guide to 10 outstanding companies in women’s health. The w...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Business Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones companies company digital digital health digital health technologies femtech health technology Innovation market women women's health Source Type: blogs
This report presents anatomopathological evidence of an early-stage malignant transformation in endometriotic tissue from a post-Cesarean scar and briefly reviews possible underlying mechanisms. A 40-year-old woman with a body mass index of 42.7 was referred to the gynecological department with recurrent pain and presence of a palpable mass in her Cesarean section scar. She had undergone this procedure 7 years earlier and began experiencing discomfort and pain at the incision site 6 months postoperatively. Surgical treatment was instituted with complete removal of the lesion. Anatomopathological examination revealed endome...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Endometriosis is an estrogen dependent, inflammatory disorder occurring in 5 –10% of reproductive-aged women. Women with endometriosis have a lower body mass index (BMI) and decreased body fat compared to those...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
CONCLUSIONS: Evidence on the effectiveness and safety of RAS compared with CLS for non-malignant disease (hysterectomy and sacrocolpopexy) is of low certainty but suggests that surgical complication rates might be comparable. Evidence on the effectiveness and safety of RAS compared with CLS or open surgery for malignant disease is more uncertain because survival data are lacking. RAS is an operator-dependent expensive technology; therefore evaluating the safety of this technology independently will present challenges. PMID: 30985921 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
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