Comparison of the immunogenicity and safety of pentavalent vaccine Quinvaxem in a compact prefilled auto-disabled (cPAD) injection system versus single-dose vials in healthy infants: a phase 3, open-label, randomized, parallel-group, non-inferiority study

Immunization is a cost-effective and life-saving intervention that prevents an estimated two to three million deaths every year from vaccine-preventable diseases.1,2 The aim of the World Health Organization (WHO) Expanded Programme on Immunization (EPI) is to protect children against life-threatening diseases like tuberculosis, diphtheria, neonatal tetanus, whooping cough, poliomyelitis, and measles, as well as hepatitis B3 and Haemophilus influenzae type b (Hib).4 According to the WHO, approximately 22.6 million children worldwide did not receive the full three doses of diphtheria–tetanus–pertussis (DTP3) vaccine in 2012.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research

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Authors: Larijani B, Foroughi Heravani N, Alavi-Moghadam S, Goodarzi P, Rezaei-Tavirani M, Payab M, Gholami M, Razi F, Arjmand B Abstract Autism spectrum disorders as a group of pediatric neurodevelopmental diseases is a crucial part of the worldwide disabilities which have influence in communication skills, social interactions, and ability to understand the concepts. The precise pathophysiology of autism spectrum disorders due to the abundance of involved mechanisms is unknown. Some of these involved mechanisms are related to genetic factors, chronic neuro inflammation, mitochondrial dysfunction, oxidative stress,...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Yale New Haven Hospital is under fire from federal prosecutors for allegations that the prestigious medical center ’sLate Career Practitioner Policy discriminates and humiliates older physicians. This month, the Equal Employment Opportunity Commission (EEOC) filed a lawsuit against the hospital accusing them of forcing radiologists to submit to neuropsychological and eye exams in order to keep their staff privileges. Physicians under 70 were not obligated to undergo these evaluations. The EEOC claimed that Yale ’s policy was enacted regardless of suspicions that doctors were experiencing neurological ...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
New research coming out of Durham could increase the effectiveness of a cocaine vaccine that blocks the illicit drug's effect – giving promise for therapeutic applications to help recovery. According to a new study by Duke University researchers, published in the journal npj Vaccines, a new formulation tested in mice has effectively negated the effects of cocaine. The drug works by pushing the body's immune system to c reate antibodies to respond against cocaine. The mice studies, according to…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Conclusions: Radial head arthroplasty with a monoblock UHMW-PE RHP is safe and effective at short-term follow-up for treating acute unreconstructable radial head fractures with satisfactory functional and radiographic outcomes. Level of Evidence: Level IV.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Special Focus: Trauma Source Type: research
Conclusions: The Ilizarov external fixator is an effective tool in the treatment of severe long-standing fixed knee flexion deformity in adults with minimal complications and good outcomes. Level of Evidence: Level II.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
Conclusions: For one-level ACDF, the anchored cage with screws has some advantage compared to the stand-alone PEEK cage in avoiding dysphagia and restoring disc space height and cervical lordosis. We suggest the anchored spacer may be a good substitute for the stand-alone cage in one-level ACDF. Level of Evidence: Level II
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
NPs should be given a more significant role in this effort.
Source: AJN - Category: Nursing Tags: Viewpoint Source Type: research
No abstract available
Source: AJN - Category: Nursing Tags: In the News Source Type: research
Publication date: Available online 20 February 2020Source: Neurología (English Edition)Author(s): J.A. Crespo Burillo, Á. Gimenez Muñoz, J.M. Pérez Trullén
Source: Neurologia - Category: Neurology Source Type: research
Publication date: Available online 20 February 2020Source: Microbes and InfectionAuthor(s): Jin-Yan Li, Zhi You, Qiong Wang, Zhi-Jian Zhou, Ye Qiu, Rui Luo, Xing-Yi GeAbstractAt the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections. Intensive research on the novel emerging human infectious coronaviruses is ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
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