Genomic epidemiology of artemisinin resistant malaria

Source: eLife - Category: Biomedical Science Tags: artemisinin drug resistance Genomics and Evolutionary Biology kelch13 malaria Microbiology and Infectious Disease Other plasmodium falciparum Source Type: research

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Publication date: February 2020Source: The Lancet Global Health, Volume 8, Issue 2Author(s): Jeremy D Keenan, Ahmed M Arzika, Ramatou Maliki, Sanoussi Elh Adamou, Fatima Ibrahim, Mariama Kiemago, Nana Fatima Galo, Elodie Lebas, Catherine Cook, Benjamin Vanderschelden, Robin L Bailey, Sheila K West, Travis C Porco, Thomas M Lietman, Paul M Emerson, Jerusha Weaver, Sheila K West, Robin L Bailey, John Hart, Amza AbdouSummaryBackgroundThe Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) trial found that biannual mass distribution of azithromycin to children younger tha...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
In this study, we investigate the dynamics of OBs in activated gametocytes of Plasmodium falciparum and Plasmodium yoelii using the female OB-specific marker protein, G377. After activation, female gametocyte OBs migrate to the parasite surface and fuse to form large vesicles beneath the parasite plasma membrane. At the marginal region of female gametocytes, fused vesicles secrete contents by exocytosis into the parasitophorous vacuole space, prior to parasite egress via the break-down of the erythrocyte membrane. This is the first detailed description of how proteins are transported through osmiophilic bodies.
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Conditions:   Malaria;   Malnutrition, Child Interventions:   Drug: AQSP Administration;   Dietary Supplement: Supplementation with Plumpy'Nut®;   Dietary Supplement: Supplementation with Vitamin A;   Dietary Supplement: Supplementation with Zinc Sponsor:   Institut de Recherche en Sciences de la Sante, Burkina Faso Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Malaria,Falciparum Intervention:   Biological: TB31F Sponsors:   Radboud University;   The PATH Malaria Vaccine Initiative (MVI) Recruiting
Source: - Category: Research Source Type: clinical trials
[AIM] Maputo -Mozambique's Coordination Mechanism for the Global Fund to Fight AIDS, Tuberculosis and Malaria on Wednesday reached consensus on the need to create strong and resilient health systems that can respond effectively to the challenges of the Sustainable Development Goals (SDGs).
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[FrontPageAfrica] Monrovia -The Liberia Coordinating Mechanism (LCM) of the Global Fund to fight AIDS, TB and Malaria have completed a two-day Country Dialogue for Region 5 counties to provide input to the development of a new joint national TB/HIV funding request for the country. River Gee, Maryland and Grand Kru which are in southeastern Liberia were grouped as region 5 counties to prioritize areas of intervention for the development of a joint TB/HIV funding request for submission to the Global Fund.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[The Conversation Africa] Kenya experienced above-average rainfall since October 2019, causing landslides and deaths. Some rivers burst their banks and dams overflowed for the first time in years.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
[Nation] One person has died while 135 others have been treated for Malaria in Elgeyo-Marakwet in the last one week as the disease spreads amidst the lack of drugs in the county.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
(University of Washington Health Sciences/UW Medicine) 3D microvessels have been created to observe how red blood cells transit ultra-small blood vessels. They squeeze single-file through microvessels to bring oxygen and nutrients. Red cells burdened with malaria stall, blocking the blood vessel. The platform is expected to have other uses in studies of how microvascular damage occurs in diabetes and sickle cell anemia. They might be further developed to supply blood circulation to organ repair patches or to 3D printed transplants.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusion: Due to general lack of awareness towards toxoplasmosis observed among both health workers and pregnant women in Temeke Municipality, we recommend health policy on maternal and child healthcare to address prenatal screening that is aimed at providing early diagnosis for any possible congenital toxoplasmosis as well as diseases that are currently screened in Tanzania such as HIV, syphilis and malaria. Integrating a One Health approach in educating medical professionals and the vulnerable population of pregnant women on the importance of congenital zoonoses will promote awareness and preventive practices towards t...
Source: African Health Sciences - Category: African Health Source Type: research
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