Parainfluenza Virus Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation: Viral Detection in the Lung Predicts Outcome.
Parainfluenza Virus Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation: Viral Detection in the Lung Predicts Outcome. Clin Infect Dis. 2014 Mar 5; Authors: Seo S, Xie H, Campbell AP, Kuypers JM, Leisenring WM, Englund JA, Boeckh M Abstract Background. Parainfluenza virus (PIV) commonly infects patients following hematopoietic cell transplantation (HCT), frequently causing lower respiratory tract disease (LRD). The definition of LRD significantly differs among studies evaluating the impact of PIV after HCT. Methods. We retrospectively evaluated 544 HCT recipients with laboratory-confirmed PIV and classified LRD into three groups: possible (PIV detection in upper respiratory tract with new pulmonary infiltrates with/without LRD symptoms), probable (PIV detection in lung with LRD symptoms without new pulmonary infiltrates), and proven (PIV detection in lung with new pulmonary infiltrates with/without LRD symptoms). Results. Probabilities of 90-day survival after LRD were 87%, 58% and 45% in possible, probable and proven cases, respectively. Patients with probable and proven LRD had significantly worse survival than those with upper respiratory tract infection (probable; HR, 5.87; p
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Conclusion For patients with central NSCLC with extensive tumor invasion, thus inability to tolerate sleeve resection or pneumonectomy, autologous lung transplantation can preserve lung function to the greatest extent with a complete tumor resection and improve postoperative quality of life. DOI: 10.3779/j.issn.1009-3419.2020.103.12
PMID: 32795142 [PubMed - in process]
Solid organ transplant recipients (OTR) have an increased incidence of developing a malignancy post-transplant, which is the 2nd leading cause of mortality in transplant patients [1,2]. The increased risk is thought to be largely due to immunosuppression in transplant patients, allowing more cancers to escape immune surveillance, similar to other immunosuppressed populations (e.g. patients with HIV) . Other theories include local immune reactions against the transplanted organ, carcinogenicity of immunosuppressants, increased surveillance, and risk from the underlying conditions that led to the need for an organ transpl...
Among other cancers, cigarette smoking is a risk factor for lung cancer and head and neck cancer . Moreover, cigarette smoke plays a causative role in various other diseases including cardiovascular, respiratory, and autoimmune diseases; allergies; and transplant rejection .
PMID: 32569475 [PubMed - as supplied by publisher]
The increased risk of malignancy after solid organ transplantation is a well-recognized phenomenon. Prolonged immunosuppressive regimens following transplant are thought to confer this risk [1,2]; furthermore, once tumors develop in these patients, the impaired host antitumor response increases the risk for metastasis while comorbidities may limit their ability to tolerate chemotherapy. It has been reported that over 4% of solid organ transplant recipients in the United States develop cancer over a 5-year period, with non-melanoma skin cancer, non-Hodgkin ’s lymphoma, and lung cancer being the most common post-transplant cancers .
Abstract The transmission of cancer from a donor organ is a rare event but has important consequences. Aim of this systematic review was to summarize all the published evidence on cancer transmission in kidney recipients. We reviewed published case reports and series describing the outcome of recipients with donor-transmitted cancer until August 2019. A total of 128 papers were included, representing 234 recipients. The most common transmitted cancers were lymphoma (n = 48, 20.5%), renal cancer (42, 17.9%), melanoma (40, 17.1%), non-small cell lung cancer (n = 13, 5.6%), neuroendocrine ...
This article reviews the current state of knowledge on predictors for BOS. DOI: 10.3779/j.issn.1009-3419.2020.101.03
Publication date: Available online 27 May 2020Source: Respiratory Medicine Case ReportsAuthor(s): Lea Deterding, Tina Körner, Gudrun Borte, Hubert Wirtz, Hans-Jürgen Seyfarth