Cytokines and persistent viral infections.

Cytokines and persistent viral infections. Cytokine. 2016 Feb 20; Authors: Beltra JC, Decaluwe H Abstract Intracellular pathogens such as the human immunodeficiency virus, hepatitis C and B or Epstein-Barr virus often cause chronic viral infections in humans. Persistence of these viruses in the host is associated with a dramatic loss of T-cell immune response due to functional T-cell exhaustion. Developing efficient immunotherapeutic approaches to prevent viral persistence and/or to restore a highly functional T-cell mediated immunity remains a major challenge. During the last two decades, numerous studies aimed to identify relevant host-derived factors that could be modulated to achieve this goal. In this review, we focus on recent advances in our understanding of the role of cytokines in preventing or facilitating viral persistence. We concentrate on the impact of multiple relevant cytokines in T-cell dependent immune response to chronic viral infection and the potential for using cytokines as therapeutic agents in mice and humans. PMID: 26907634 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research

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The direct-acting antiviral (DAA) combination of glecaprevir and pibrentasvir is effective in patients with genotype 1 hepatitis C virus (HCV) infection after failure of treatment with sofosbuvir plus an NS5A inhibitor, according to results from a new open-label trial.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Introduction: Several studies have shown an association between psoriasis and hepatitis C virus infection. To assess this relationship, we have evaluated the frequency of psoriasis among a population of patients receiving treatment for hepatitis C infection.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
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Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
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Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
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Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conditions:   Hepatitis C;   Chronic Hepatitis c;   Hepatitis C, Chronic Intervention:   Other: EC clinic support - whole of practice interventions delivery through nurse-led model Sponsors:   Macfarlane Burnet Institute for Medical Research and Public Health Ltd;   Burnet Institute;   The Alfred;   St Vincent's Hospital Melbourne;   HepatitisVictoria;   Harm Reduction Australia;   Victoria State Government;   Gilead Sciences;   National Health and Medical Research C ouncil, Australia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
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Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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