NOX2-dependent regulation of inflammation.

NOX2-dependent regulation of inflammation. Clin Sci (Lond). 2016 Apr 1;130(7):479-90 Authors: Singel KL, Segal BH Abstract NADPH oxidase (NOX) isoforms together have multiple functions that are important for normal physiology and have been implicated in the pathogenesis of a broad range of diseases, including atherosclerosis, cancer and neurodegenerative diseases. The phagocyte NADPH oxidase (NOX2) is critical for antimicrobial host defence. Chronic granulomatous disease (CGD) is an inherited disorder of NOX2 characterized by severe life-threatening bacterial and fungal infections and by excessive inflammation, including Crohn's-like inflammatory bowel disease (IBD). NOX2 defends against microbes through the direct antimicrobial activity of reactive oxidants and through activation of granular proteases and generation of neutrophil extracellular traps (NETs). NETosis involves the breakdown of cell membranes and extracellular release of chromatin and neutrophil granular constituents that target extracellular pathogens. Although the immediate effects of oxidant generation and NETosis are predicted to be injurious, NOX2, in several contexts, limits inflammation and injury by modulation of key signalling pathways that affect neutrophil accumulation and clearance. NOX2 also plays a role in antigen presentation and regulation of adaptive immunity. Specific NOX2-activated pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2), a transcriptional fact...
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Clin Sci (Lond) Source Type: research

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In this study we explored the use of a natural compound rubusoside (RUB) as a solubilizer to enhance the solubility of a fluorescence-labeled C6-Ceramide (NBD C6-Ceramide) and to characterize its pharmacokinetics and tissue distribution in an animal model. RUB significantly enhanced the solubility of NBD C6-Ceramide by forming nanomicelles, and efficiently delivered NBD C6-Ceramide in rats by oral and intravenous administration. RUB loaded 1.96% of NBD C6-Ceramide in the nanomicelles and solubilized it to a concentration of 3.6 mg/mL in water. NBD C6-Ceramide in nanomicelles remained stable in aqueous solutions, all...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Publication date: Available online 10 December 2019Source: Journal of Food Composition and AnalysisAuthor(s): Afsaneh Mohajer, Abbas Norouzian Baghani, Parisa Sadighara, Kiandokht Ghanati, Shahrokh NazmaraAbstractIn this current study, the contents of heavy metals including Pb, As, Cr, Cd, Zn, Cu, and Mn in imported rice bran oil in Iran were investigated with microwave digestion method based on an inductively coupled plasma optical emission spectrometry system (ICP-OES). The concentrations range of Pb, Cr, Cd, As, Zn, and Cu in rice bran oil samples were measured as 0.066 - 0.30, 0.008 - 0.014, 0.005 - 0.01, 0.047- 0.01, ...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
Authors: Hill BG, Shiva S, Ballinger S, Zhang J, Darley-Usmar VM Abstract It is now becoming clear that human metabolism is extremely plastic and varies substantially between healthy individuals. Understanding the biochemistry that underlies this physiology will enable personalized clinical interventions related to metabolism. Mitochondrial quality control and the detailed mechanisms of mitochondrial energy generation are central to understanding susceptibility to pathologies associated with aging including cancer, cardiac and neurodegenerative diseases. A precision medicine approach is also needed to evaluate the ...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Publication date: Available online 10 December 2019Source: Artificial Intelligence in MedicineAuthor(s): Sarah Ali Abdelaziz Ismael, Ammar Mohammed, Hesham HefnyAbstractCancer is the second leading cause of death after cardiovascular diseases. Out of all types of cancer, brain cancer has the lowest survival rate. Brain tumors can have different types depending on their shape, texture, and location. Proper diagnosis of the tumor type enables the doctor to make the correct treatment choice and help save the patient's life. There is a high need in the Artificial Intelligence field for a Computer Assisted Diagnosis (CAD) syste...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: Available online 6 December 2019Source: Radiation Physics and ChemistryAuthor(s): Vimal Kishore, Lalit Kumar, Manindra Bhushan, Girigesh YadavAbstractTo fabricate a cost effective low density heterogeneous phantom with the combination of racemosa wood and Poly (methyl methacrylate) (PMMA) for dose verification in the high energy photon beam. The use of solid tissue equivalent material for dose verification is a well accepted and common practice for dosimetric studies. The measured Hounsfield units (HU), relative electron density, mass density were −776.6 ± 72.4, 0.223 ± 0.072, ...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
Neutrophils, as "Trojan horses", participate in the delivery of therapeutical PLGA nanoparticles into a tumor based on the chemotactic effect. Drug Deliv. 2020 Dec;27(1):1-14 Authors: Hao J, Chen J, Wang M, Zhao J, Wang J, Wang X, Li Y, Tang H Abstract Inspired by the fact that leukocytes have innate phagocytic functions and oriented migration capabilities in response to chemoattractants, we have unveiled that endogenous neutrophils as "Trojan horses", participate in the delivery of nanoparticles in an "in vivo self-armed assembly" manner. Neutrophils were the main populat...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Authors: Chaaben Arij B, Nesrine O, Hayet D, Fayza A, Hajer A, Tesnim M, Latifa H, Cathy F, Wahid B, Rajagopal K, Dominique C, Sonia G, Fethi G, Ryad T Abstract The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. A part from its genetic diversity, MICA is characterized by the presence of membrane-bound and soluble isoform (sMICA) and by the propensity to elicit antibody-mediated allogeneicity (MICA Abs). Altogether such properties are important in the cancer setting. Here, we investigated whether MICA polymorphism, serum level of sMICA and MICA ant...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): Puspendu Roy, Deblina Sarkar, Paramita Ghosh, Chandan Kumar Manna, Nabendu Murmu, Tapan Kumar MondalAbstractA new fluorescent Rh(III) cyclometalated complex, [Rh(PPh3)2(L)Cl] (1) is synthesized via sp2(C)–S bond activation of a thioether containing azo-phenol ligand (L-SCH2CH3). The pseudo octahedral geometry around rhodium is confirmed by single crystal X-ray diffraction method. Cyclic voltammogram of the complex exhibits a quasi-reversible oxidation couple with E1/2 of 0.74 V (ΔE = 100 mV) along wi...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Authors: Serrano Peluffo AR, González Ventosa A, Camós Carreras A, Martínez Hernández D, Llorenç Bellés V, Adán Civera A PMID: 31812291 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Authors: Pigniczki D, Rutka M, Farkas K, Molnar T PMID: 31818162 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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