Immunotherapy of Fungal Infections.

Immunotherapy of Fungal Infections. Immunol Invest. 2015 Nov;44(8):738-76 Authors: Datta K, Hamad M Abstract Fungal organisms are ubiquitous in the environment. Pathogenic fungi, although relatively few in the whole gamut of microbial pathogens, are able to cause disease with varying degrees of severity in individuals with normal or impaired immunity. The disease state is an outcome of the fungal pathogen's interactions with the host immunity, and therefore, it stands to reason that deep/invasive fungal diseases be amenable to immunotherapy. Therefore, antifungal immunotherapy continues to be attractive as an adjunct to the currently available antifungal chemotherapy options for a number of reasons, including the fact that existing antifungal drugs, albeit largely effective, are not without limitations, and that morbidity and mortality associated with invasive mycoses are still unacceptably high. For several decades, intense basic research efforts have been directed at development of fungal immunotherapies. Nevertheless, this approach suffers from a severe bench-bedside disconnect owing to several reasons: the chemical and biological peculiarities of the fungal antigens, the complexities of host-pathogen interactions, an under-appreciation of the fungal disease landscape, the requirement of considerable financial investment to bring these therapies to clinical use, as well as practical problems associated with immunizations. In this general, non-exhaustiv...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

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Publication date: Available online 25 July 2019Source: Journal de Mycologie MédicaleAuthor(s): K. Samaras, A.-M. Markantonatou, D. Karapiperis, P. Digonis, N. Kartalis, N. Kostogloudis, T.-A. VyzantiadisAbstractSaksenaea vasiformis is an emerging human pathogen, belonging to the order Mucorales of the subphylum Mucormycotina, most often associated with rhino-cerebral, cutaneous and subcutaneous infections following trauma. A review of the published literature was attempted on the occasion of a cutaneous leg infection with favorable outcome in a young immunocompetent man after mild injury. The overall aim was the fac...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
We report a case of a patient who acquired CBM in a nontropical area after bipulmonary transplant. A 52-year-old who had received a bipulmonary transplant 30 days ago presented with an asymptomatic, 4- × 2.5-cm diameter violaceous plaque, with ulceronecrotic tissue and exudative small abscesses in his right forearm.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Chromoblastomycosis (CBM) is one of the most prevalent implantation fungal infections and is observed mostly in persons living in tropical and subtropical zones around the planet. It is also strongly associated with agricultural activities, which further underscores your occupational nature. This disease is characterized by traumatic inoculation, leading to an initial cutaneous lesion at the inoculation site; a nonprotective T helper type 2 (Th2); the presence of muriform (sclerotic) cells in the affected tissue; and progressive and chronic involvement of cutaneous and subcutaneous tissular structures and a f...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Case: A 71-year-old male with acute myeloid leukemia (AML) on posaconazole for invasive fungal disease prophylaxis was found to have necrotic, escharred skin lesions on his bilateral forearms that developed while awaiting resolution of chemotherapy-induced neutropenia. 4-mm punch biopsies were performed through the necrotic center of each lesion and frozen sections were sent for investigation. Right forearm skin biopsy and frozen section were positive for angioinvasive fungal infection within the dermis and subcutis, which demonstrated vascular occlusion by numerous fungal hyphae.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: The zoophilic dermatophytosis is getting attention because animals come with risks for spreading fungal infections. However, the human –pet relationship and pet abandonment in who infected with zoophilic dermatophytes have never been concerned
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Tinea unguium, or onychomycosis, is a fungal infection of the nail caused by dermatophytes, yeasts, and nondermatophyte moulds. Effective and efficient treatment is necessary to successfully manage these stubborn infections.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Murphy EC, Friedman AJ Abstract Cutaneous fungal infections account for millions of office visits per year, yet their varied presentations often lead to misdiagnosis. If dermatology clinics are Clinical Laboratory Improvement Amendment (CLIA) certified, direct microscopy with potassium hydroxide or other stains can be used to inexpensively and rapidly diagnose fungal infections. In this survey, we examined dermatologists’ perceptions of fungal preparations and CLIA certification to identify barriers that prevent the use of these bedside diagnostics. The response rate was 13% (n=308, based on the numb...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Dermatophytes cause superficial fungal infections that pose public health problem to man and animals. Long term treatment with antifungal agents is required to control these infections. Various parts of Azadirachta indica are claimed to have significant medicinal value in treatment of infections especially ringworm. To determine the antifungal activity of the oil and fractions against dermat...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
Invasive mycoses remain underdiagnosed and difficult to treat. Hospitalized individuals with compromised immunity increase in number and constitute the main risk group for severe fungal infections. Current antifungal therapy is hampered by slow and insensitive diagnostics and frequent toxic side effects of standard antifungal drugs. Identification of new antifungal compounds with high efficacy and low toxicity is therefore urgently required. We investigated the antifungal activity of tempol, a cell-permeable nitroxide. To narrow down possible mode of action we used RNA-seq technology and metabolomics to probe for pathways ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
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