Anti-infectious human vaccination in historical perspective.
Anti-infectious human vaccination in historical perspective. Int Rev Immunol. 2015 Nov 25;:1-32 Authors: D'Amelio E, Salemi S, D'Amelio R Abstract A brief history of vaccination is presented since the Jenner's observation, through the first golden age of vaccinology (from Pasteur's era to 1938), the second golden age (from 1940 to 1970), until the current period. In the first golden age, live, such as Bacille Calmette Guérin (BCG), and yellow fever, inactivated, such as typhoid, cholera, plague, and influenza, and subunit vaccines, such as tetanus and diphtheria toxoids, have been developed. In the second golden age, the cell culture technology enabled polio, measles, mumps, and rubella vaccines be developed. In the era of modern vaccines, in addition to the conjugate polysaccharide, hepatitis A, oral typhoid, and varicella vaccines, the advent of molecular biology enabled to develop hepatitis B, acellular pertussis, papillomavirus, and rotavirus recombinant vaccines. Great successes have been achieved in the fight against infectious diseases, including the smallpox global eradication, the nearly disappearance of polio, the control of tetanus, diphtheria, measles, rubella, yellow fever, and rabies. However, much work should still be done for improving old vaccines, such as BCG, anthrax, smallpox, plague, or for developing effective vaccines against old or emerging infectious threats, such as human-immunodeficiency-virus, malaria, hepatiti...
[New Times] The Ministry of Health Monday held a preparatory meeting of the Kigali Summit on Malaria and NTDs that will take place on the sidelines of the 26th Commonwealth Head of Government (CHOGM) meeting to be held in June this year.
While global stock markets plunged Monday amid concerns about the spread of a new strain of the coronavirus, the share price of a Montgomery County biopharmaceutical company working on a potential vaccine continues to soar. Inovio Pharmaceuticals (NASDAQ: INO) of Plymouth Meeting is one of two companies to receive grants from the Coalition for Epidemic Preparedness Innovations (CEPI) to support work on a potential vaccine against the recently emerged coronavirus strain. CEPI, a public-private alliance…
The macrolide antibacterial is now approved in oral suspension and tablets for treatment of Clostridioides difficile-associated diarrhea (CDAD) in children aged 6 months and older.FDA Approvals
ConclusionWe herein reported a subphrenic abscess due to Clostridium perfringens after hepatic resection for hepatocellular carcinoma following emphysematous cholecystitis.
What are the symptoms caused by the virus from Wuhan in China, how is it transmitted from one person to another, and how is it related to Sars?Britain under pressure to evacuate UK nationalsWhere has the virus spread?Coronavirus latest - live updatesIt is a novel coronavirus – that is to say, a member of the coronavirus family that has never been encountered before. Like other coronaviruses, it has come from animals. Many of those infected either worked or frequently shopped in the Huanan seafood wholesale market in the centre of the Chinese city, which also sold live and newly slaughtered animals. New and troubling ...
ONCOS-102, a promising immunotherapy vaccine, is moving closer to becoming a part of future first-line treatment for mesothelioma. Early clinical trial results announced this week show safety and efficacy when the vaccine is used in combination with standard-of-care chemotherapy for patients with inoperable pleural mesothelioma. Targovax, a Scandinavian pharmaceutical company developing the drug, is moving forward with another study combining ONCOS-102 with a checkpoint inhibitor drug such as Keytruda (pembrolizumab) or Opdivo (nivolumab), along with chemotherapy. “We have seen enough data at this point to be going ...
This study demonstrates that successful DAA therapy for HCV provides an initial rapid resolution of liver inflammation followed by a steady improvement in liver fibrosis and metabolic liver function.Journal of Viral Hepatitis
Might data from ambulance dispatch calls provide another source for influenza surveillance?Emerging Infectious Diseases
The Maryland biotech's latest move reflects its fundamental strategy: Watch for opportunities to address a virus outbreak.
[Observer] A disease epidemic with the potential for pandemic proportions is upon us again. Unlike the Ebola Virus Disease (EVD) which caught Liberia and neighboring Sierra Leone and Guinea off guide, there is a worldwide alarm on the emergence of a coronavirus in the city of Wuhan, Hubei Province, China.
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