Immune globulin

Intravenous immune globulin (IVIG) preparations consist of concentrated immunoglobulins (Ig), principally immunoglobulin G (IgG), with a subclass distribution that largely reflects that of IgG in normal human serum. Pooled serum is collected from large numbers of donors, ranging from 1,000 to more than 50,000, depending on the manufacturer. All U.S. IVIG manufacturers use Cohn-Oncley ethanol fractionation (fraction II) as an initial step in the preparation of immunoglobulin. Subsequent steps differ among preparations and include ion exchange chromatography, ultrafiltration, enzymatic digestion, manipulation of the pH and salt concentration, and organic solvent-detergent partitioning. These procedures remove contaminants, minimize the concentration of IgG aggregates, and deactivate viral contaminants, such as hepatitis B and C viruses and HIV. Donor serum samples are screened for antibodies to HIV, hepatitis C virus, and hepatitis B surface antigen and for elevated levels of alanine aminotransferase. [#]
Source: Aids Info Drugs - Category: Drugs & Pharmacology Source Type: research

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Conclusions: Our findings describe the clinical characteristics and outcomes of PLWHIV at a major tertiary referral hospital in Saudi Arabia. The non AIDS related disease is the major cause of death in HIV infected patients. Early diagnosis and initiation of antiretroviral therapy resulted in a significant decrease in morbidity and mortality. PMID: 32893278 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Objectives: Despite free access to antiretroviral therapy (ART) from 1996 onward, and treatment for all people living with HIV (PLWHIV) from 2013, mortality in Brazil has not homogeneously decreased. We investigated to what extent delayed ART, hepatitis coinfections and sociodemographic factors predict all-cause mortality in Brazilian PLWHIV. Design: We included PLWHIV at least 18 years, with complete CD4+ cell count data, followed up between 2007 and 2015 in Brazil. Methods: After multiple imputation, an extended Cox model helped estimate the effects of fixed and time-varying covariates on mortality. Results: T...
Source: AIDS - Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research
There has been little published data on estimates of HBV and/or HCV coinfection in HIV-positive patients in China or an understanding of how this coinfection varies with different factors. Therefore, this stud...
Source: Virology Journal - Category: Virology Authors: Tags: Review Source Type: research
AbstractCoinfections of hepatitis C virus (HCV) and/or hepatitis B virus (HBV) with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) are associated with high morbidity and mortality and poor prognosis. The main objective of this study was to evaluate the prevalence of HCV and/or HBV coinfections among people who inject drugs (PWID) and female sex workers (FSWs) who live with HIV/AIDS worldwide. Data sources were searched from January 2008 to October 2018 in different databases, including PubMed, Scopus, Web of Science, Embase, and Ovid. Data were analyzed in Stata 14 software using the Metaprop co...
Source: Archives of Virology - Category: Virology Source Type: research
Abstract Following the advent of penicillin as first widely used antibiotic during World War II, viruses have steadily replaced bacteria as major agents of infections, particularly for microorganisms that can spread globally. Good examples are pandemics caused by HIV, hepatitis B, hepatitis C, and nowadays severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus of coronavirus disease (COVID)-19. PMID: 32628223 [PubMed - as supplied by publisher]
Source: AIDS Reviews - Category: Infectious Diseases Authors: Tags: AIDS Rev Source Type: research
This report describes the June 2020 U.S. Public Health Service guidelines which recommend actions healthcare providers can take before and after transplant to minimize the risk of infection
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Hepatitis Hepatitis B Hepatitis C HIV/AIDS MMWR Morbidity & Mortality Weekly Report Organ Transplants Source Type: news
Conclusion: Children in orphanage A came to us at a younger age, in more advanced stage of disease, and were more malnourished. Orphanage A was started on ART earlier in life. The prevalence of TB was higher in orphanage A prior to ART. MDR-TB was seen in both orphanages, with prevalence ranging from 3.5% to 5.5%.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusion: The rising prevalence rates of HIV; HBV; HCV and syphilis among different groups suggests that blood transfusion is still very unsafe in this community and emphasis should be laid on donor education and donor self-exclusion, implementation of strict donor screening criteria, pre-donation counseling, and more sensitive screening methods. Furthermore, donors with a history of sexually transmitted infections should be totally excluded from all donations.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusion: Children in orphanage A came to us at a younger age, in more advanced stage of disease, and were more malnourished. Orphanage A was started on ART earlier in life. The prevalence of TB was higher in orphanage A prior to ART. MDR-TB was seen in both orphanages, with prevalence ranging from 3.5% to 5.5%.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusion: The rising prevalence rates of HIV; HBV; HCV and syphilis among different groups suggests that blood transfusion is still very unsafe in this community and emphasis should be laid on donor education and donor self-exclusion, implementation of strict donor screening criteria, pre-donation counseling, and more sensitive screening methods. Furthermore, donors with a history of sexually transmitted infections should be totally excluded from all donations.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
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