New insights into acne pathogenesis: Exploring the role of acne-associated microbial populations

Publication date: Available online 13 February 2016 Source:Dermatologica Sinica Author(s): Bipul Kumar, Rajiv Pathak, P. Bertin Mary, Diksha Jha, Kabir Sardana, Hemant K. Gautam Acne vulgaris, a prevalent disorder of the skin, is found to increase the incidence of suicidal ideation in acne patients (∼7.1%). This creates a dilemma in the mind whether acne is a life threatening disease among humans. The main inducer for this multifactorial disease is microbial fluctuation of common resident microbes on the skin with each microbe possessing their own purpose and style in protecting the human body. For acne progression, the microbial population has to get around the defense barriers of the host skin and be able to also resist them in order to survive. These matters have been resolved by their pathogenic lifecycle and associated virulence factors coded within their pathogenic islands in the single circular chromosome. This review addresses the different microbial populations residing in acne lesions and promoting acne by emphasizing their pathogenic mechanisms and the genes associated with virulence factors involved in the development of acne. Model systems such as animal models and cell culture models in studying the pathogenic lifestyle of the microbes are also addressed.
Source: Dermatologica Sinica - Category: Dermatology Source Type: research

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Patients who take isotretinoin for severe acne may be vulnerable to several psychiatric conditions, according to astudy published today inJAMA Dermatology. Specifically, depressive disorders, anxiety disorders, and mood swings were among the most common psychiatric adverse events in patients taking isotretinoin reported to the Food and Drug Administration (FDA) over a 20-year period.Although previous studies and media reports have highlighted an association between suicidality and depression in patients taking isotretinoin, “our results suggest that other, underappreciated psychiatric adverse events may be linked to ...
Source: Psychiatr News - Category: Psychiatry Tags: Accutane acne adverse events anxiety depression FDA iPLEDGE irritability isotretinoin mood disorders suicidal ideation suicide Source Type: research
AbstractHidradenitis suppurativa/acne inversa (HS) is one of the most debilitating inflammatory chronic skin diseases and it heavily impairs the emotional and relational life of the patients. Despite its clinical and epidemiological relevance, its psychological correlates are still largely unexplored. The aim of the present study was to investigate the psychological and emotional impact of HS, with a specific focus on psychiatric symptoms, particularly depression, suicidal ideation, self-esteem, anger, and some personality traits. Thirty eight patients diagnosed with HS (HS Group) were compared with a control group of 28 o...
Source: Journal of Clinical Psychology in Medical Settings - Category: Psychiatry & Psychology Source Type: research
This study aimed to evaluate the quality of life, depression, anxiety,...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
ConclusionWe found that neither isotretinoin nor antibiotic treatment affected the levels of depression, anxiety, and suicide in acne patients. Moreover, both isotretinoin and antibiotic treatment were shown to improve the quality of life, social anxiety, and obsessive –compulsive symptoms in acne patients. However, clinicians should be careful about psychiatric side effects in patients using isotretinoin. Further studies with a larger number of cases and with a longer follow-up period are needed to investigate the complex effects of isotretinoin on the central nervous system.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
CONCLUSION: We found that neither isotretinoin nor antibiotic treatment affected the levels of depression, anxiety, and suicide in acne patients. Moreover, both isotretinoin and antibiotic treatment were shown to improve the quality of life, social anxiety, and obsessive-compulsive symptoms in acne patients. However, clinicians should be careful about psychiatric side effects in patients using isotretinoin. Further studies with a larger number of cases and with a longer follow-up period are needed to investigate the complex effects of isotretinoin on the central nervous system. PMID: 31175639 [PubMed - as supplied by publisher]
Source: Paediatric Drugs - Category: Pediatrics Authors: Tags: Paediatr Drugs Source Type: research
BACKGROUND: Isotretinoin is the only effective treatment for severe acne. An isotretinoin-related suicide risk is still debated and under scrutiny by regulatory agencies. Our objectives were: to assess the risk of suicide attempt before, during and after i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The teenage years are hard on kids’ sense of identity and self-esteem, especially as their bodies and minds are changing and growing at a rapid rate. As a parent, it may feel like you are jumping through mental and emotional hoops, doing your best to build up your child while still maintaining discipline. However, adolescents who struggle with body dysmorphic disorder (BDD) may need more help than most parents may realize. Body Dysmorphic Disorder Strikes At A Vulnerable Age Body dysmorphic disorder is a mental disorder that leads individuals to constantly think about their perceived appearance flaws. These flaws may...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Eating Disorders Parenting Perfectionism Adolescence Body dysmorphia Body Image Teenagers Source Type: blogs
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast General Relationships Schizophrenia Source Type: blogs
ConclusionsThe association of isotretinoin exposure with prenatal developmental toxicity is well established. Though numerous reports also link isotretinoin treatment with psychiatric side effects, this association remains controversial. The extent to which isotretinoin influences pediatric and adult development and cognition, and whether and why certain individuals may be susceptible to psychiatric side effects, remains to be clarified.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research
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