Presence or Absence of QTc Prolongation in Buprenorphine-Naloxone Among Youth With Opioid Dependence

Objectives: The aim of the study was to evaluate buprenorphine-naloxone effects on the QTc in youth with opioid dependence. Buprenorphine is a partial agonist that is an effective treatment for opioid dependence. Compared with methadone, it has a lower risk of QTc prolongation in adults, but is less studied in the youth. It may also reduce the risk of torsades de pointes (TdP)—an uncommon variant of polymorphic ventricular tachycardia—that can result in syncope, ventricular fibrillation, and sudden death. Methods: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with opioid dependence. The participants were randomized to a 2-week (DETOX) or a 12-week course of buprenorphine-naloxone (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in men) and 470 milliseconds (in women) indicated a prolonged QTc. Results: Mean QTc intervals were higher for BUP than for DETOX participants at baseline, week 4, and week 12 (P = 0.045), and women had longer mean QTc intervals than men (P 
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research

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Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
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Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research
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Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Source Type: blogs
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Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
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Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue acute confusional state delirium diabetes hyperglycemia psychosis Source Type: research
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Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research binge eating obesity phentermine–topiramate Qsymia® weight loss Source Type: research
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Source: Heart Rhythm - Category: Cardiology Authors: Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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Source: Addictive Behaviors - Category: Addiction Authors: Tags: Addict Behav Source Type: research
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