Imaging fungal infections in children

Abstract Fungal infections in children rarely occur, but continue to have a high morbidity and mortality despite the development of newer antifungal agents. It is essential for these infections to be diagnosed at the earliest possible stage so appropriate treatment can be initiated promptly. The addition of high-resolution computer tomography (HR CT) has helped in early diagnosis making; however, it lacks both sensitivity and specificity. Metabolic changes precede anatomical changes and hybrid imaging with positron emission tomography (PET) integrated with imaging modalities with high anatomical resolution such as CT or magnetic resonance imaging (MRI) is likely to detect these infections at an earlier stage with higher diagnostic accuracy rates. Several authors presented papers highlighting the advantages of PET/CT in imaging fungal infections. These papers, however, usually involve a limited number of patients and mostly adults. Fungal infections behave different in children than in adults, since there are differences in epidemiology, imaging findings, and response to treatment with antifungal drugs. This paper reviews the literature and explores the use of hybrid imaging for diagnosis and therapy decision making in children with fungal infections.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research

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We report a case of a patient who acquired CBM in a nontropical area after bipulmonary transplant. A 52-year-old who had received a bipulmonary transplant 30 days ago presented with an asymptomatic, 4- × 2.5-cm diameter violaceous plaque, with ulceronecrotic tissue and exudative small abscesses in his right forearm.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Chromoblastomycosis (CBM) is one of the most prevalent implantation fungal infections and is observed mostly in persons living in tropical and subtropical zones around the planet. It is also strongly associated with agricultural activities, which further underscores your occupational nature. This disease is characterized by traumatic inoculation, leading to an initial cutaneous lesion at the inoculation site; a nonprotective T helper type 2 (Th2); the presence of muriform (sclerotic) cells in the affected tissue; and progressive and chronic involvement of cutaneous and subcutaneous tissular structures and a f...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Authors: Murphy EC, Friedman AJ Abstract Cutaneous fungal infections account for millions of office visits per year, yet their varied presentations often lead to misdiagnosis. If dermatology clinics are Clinical Laboratory Improvement Amendment (CLIA) certified, direct microscopy with potassium hydroxide or other stains can be used to inexpensively and rapidly diagnose fungal infections. In this survey, we examined dermatologists’ perceptions of fungal preparations and CLIA certification to identify barriers that prevent the use of these bedside diagnostics. The response rate was 13% (n=308, based on the numb...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Dermatophytes cause superficial fungal infections that pose public health problem to man and animals. Long term treatment with antifungal agents is required to control these infections. Various parts of Azadirachta indica are claimed to have significant medicinal value in treatment of infections especially ringworm. To determine the antifungal activity of the oil and fractions against dermat...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
Invasive mycoses remain underdiagnosed and difficult to treat. Hospitalized individuals with compromised immunity increase in number and constitute the main risk group for severe fungal infections. Current antifungal therapy is hampered by slow and insensitive diagnostics and frequent toxic side effects of standard antifungal drugs. Identification of new antifungal compounds with high efficacy and low toxicity is therefore urgently required. We investigated the antifungal activity of tempol, a cell-permeable nitroxide. To narrow down possible mode of action we used RNA-seq technology and metabolomics to probe for pathways ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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