Micronuclei in mouse embryos Cell Biology

Chromosome segregation defects in cancer cells lead to encapsulation of chromosomes in micronuclei (MN), small nucleus-like structures within which dangerous DNA rearrangements termed chromothripsis can occur. Here we uncover a strikingly different consequence of MN formation in preimplantation development. We find that chromosomes from within MN become damaged and fail...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research

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Publication date: Available online 27 January 2020Source: Inorganic Chemistry CommunicationsAuthor(s): Camila F.N. da Silva, Loyanne Carla Barbosa Ramos, Thomas N. Rohrabaugh, Jessica Vandervord, Roberto Santana da Silva, Claudia Turro, Sofia NikolaouAbstractThis work evaluates the cytotoxicity of [Ru3(μ3-O)(μ-OAc)5{μ-η1(C),η2(N,N)-phen}(py)2](PF6) (1), a triruthenium acetate cluster combined with an ortho-metallated 1,10-phenanthroline (phen) ligand, along with its interactions with biomolecules. In vitro cytotoxicity tests against the B16F10 (murine melanoma) and L929 (fibroblast) cell lines showed that ...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/C9DT04335G, PaperShihao Li, Lin Zhang Photothermal therapy (PTT), rising the temperature triggered only by light signals at tumor sites to remove cancer cells has been considered as an attractive strategy in cancer therapy. Nevertheless, the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Conclusion: it was difficult to experience and accept changes in work activities. The support of family, friends and coworkers was paramount to cope with this process, which should also be taken into account by the health team, especially nursing.RESUMO Objetivo: compreender o significado das atividades de trabalho para mulheres jovens com c âncer de mama. Método: estudo qualitativo que utilizou como referencial teórico o Interacionismo Simbólico e, metodológico, o Discurso do Sujeito Coletivo. Desenvolvido em um ambulatório de mastologia e em um núcleo de reabilitaç&a...
Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
Longtime Inspira Health executive John A. DiAngelo announced Monday he will retire at the end of the year. DiAngelo has been with Inspira Health and its predecessor, South Jersey Healthcare, since 2000. He has served as CEO since 2014 and was CFO before that. South Jersey Healthcare merged with Underwood-Memorial Hospital in Woodbury eight years ago to create what would become Inspira Health. The Mul lica Hill-based health system has grown to encompass three hospitals, a cancer center, and a large…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
ConclusionThe results suggest that non-surgical management of patients with radiologic-pathologic concordant IDP without atypia diagnosed on CNB may be appropriate in routine practice.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsThis procedure is very useful due to its minimal invasiveness, ease of thoracic procedure, and prevention of reflux in patients with EGJ cancer. To our knowledge, this is the first report of thoracoscopic esophagogastrostomy performed using the double-flap technique for EGJ cancer.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 2 January 2020Source: European Journal of Surgical OncologyAuthor(s): Paul A. Kolarsick, Matteo Sacchi, Antonino Spinelli, Steven D. WexnerAbstractWith an aging population comes a greater incidence of colorectal cancer and a corresponding need for surgical resection in the geriatric population. This heterogeneous group of patients may benefit from multidisciplinary pre-operative evaluation and optimization, prehabilitation, enhanced recovery protocols, and a minimally invasive approach to resection. Concerns regarding the ability of the older patient to tolerate the physiologic demands of...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Information was obtained from the cancer center representatives, cancer center annual reports and The Association of Community Cancer Centers.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Source Type: news
Feb 4, 2020. . Sponsored by Rural Health Research Gateway
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
ONCOS-102, a promising immunotherapy vaccine, is moving closer to becoming a part of future first-line treatment for mesothelioma. Early clinical trial results announced this week show safety and efficacy when the vaccine is used in combination with standard-of-care chemotherapy for patients with inoperable pleural mesothelioma. Targovax, a Scandinavian pharmaceutical company developing the drug, is moving forward with another study combining ONCOS-102 with a checkpoint inhibitor drug such as Keytruda (pembrolizumab) or Opdivo (nivolumab), along with chemotherapy. “We have seen enough data at this point to be going ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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