Pediatric Asthma and Viral Infection.

Pediatric Asthma and Viral Infection. Arch Bronconeumol. 2016 Jan 4; Authors: Garcia-Garcia ML, Calvo Rey C, Del Rosal Rabes T Abstract Respiratory viral infections, particularly respiratory syncytial virus (RSV) and rhinovirus, are the most importance risk factors for the onset of wheezing in infants and small children. Bronchiolitis is the most common acute respiratory infection in children under 1year of age, and the most common cause of hospitalization in this age group. RSV accounts for approximately 70% of all these cases, followed by rhinovirus, adenovirus, metapneumovirus and bocavirus. The association between bronchiolitis caused by RSV and the development of recurrent wheezing and/or asthma was first described more than 40years ago, but it is still unclear whether bronchiolitis causes chronic respiratory symptoms, or if it is a marker for children with a genetic predisposition for developing asthma in the medium or long term. In any case, sufficient evidence is available to corroborate the existence of this association, which is particularly strong when the causative agent of bronchiolitis is rhinovirus. The pathogenic role of respiratory viruses as triggers for exacerbations in asthmatic patients has not been fully characterized. However, it is clear that respiratory viruses, and in particular rhinovirus, are the most common causes of exacerbation in children, and some type of respiratory virus has been identified in over 90% of children hospi...
Source: Archivos de Bronconeumologia - Category: Respiratory Medicine Authors: Tags: Arch Bronconeumol Source Type: research

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ConclusionThis review summarizes research on the traditional use, phytochemistry, biological activities, and toxicology of P. cauliflora. Although P. cauliflora possesses significant biological activities, much of its ethnomedicinal use has not been scientifically evaluated. Well-designed pharmacological and toxicological assays and randomized clinical trials are still needed to validate its ethnopharmacological use as an herbal medicine.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS In hyperoxia-induced rat models of BPD, hBD2 promotes alveolarization and improves pulmonary function. The mechanism may contribute in alleviating inflammation response and inhibiting pro-inflammatory factors including IL-1ß, IL-6, and TNF-alpha. PMID: 31411185 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Clay-Williams R, Braithwaite J Abstract This chapter presents an overview of Resilient Health Care (RHC), introducing two aspects of RHC that are important for designing sustainable digital health systems and for considering implementation outcomes: (1) understanding how normal variation in everyday work can affect implementation of digital health interventions, and (2) the role of information systems in coping with unexpected events. The importance of considering how variation in everyday work can lead to wanted and unwanted outcomes when designing information systems is illustrated through a case study o...
Source: Studies in Health Technology and Informatics - Category: Information Technology Tags: Stud Health Technol Inform Source Type: research
Conclusions: Ov/Ob children had similar PRD to nOv/nOb children and were prone to repeat magnesium dosing. Previous hospitalization for exacerbation was positively associated with increasing BMI percentile. Additional research should investigate differential magnesium use by weight status, quantifying risks and benefits. PMID: 31411907 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Bharti Gaur, Siddhartha Saha, A Danielle Iuliano, Sanjay K Rai, Anand Krishnan, Seema Jain, Brett Whitaker, Jonas Winchell, Renu B Lal, Shobha BroorIndian Journal of Medical Microbiology 2019 37(1):105-108 Historical specimens collected from hospitalized children were tested for the following 13 viruses: influenza A and B; respiratory syncytial virus (RSV); parainfluenza viruses 1–3; human metapneumovirus; rhinovirus; coronaviruses 229E, OC43, NL63 and HKU1 and Adenovirus using monoplex real-time reverse transcriptase polymerase chain reaction (rRT-PCR). They were retested using TaqMan Array Card (TAC), a micro-flui...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Conclusions: The ACO cohort with statin use exhibited the lower risk of hepatic, renal, and heart failure than any other cohort, regardless of age, sex, comorbidities, or ICS or OS use. Regarding the combined use of statins and ICS, the risks of hepatic failure were lower. For the combined use of statins and OS, the hepatic, renal and heart failure were less frequent.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
As the first and key step of traditional Chinese medicine (TCM) guided drug development, lead discovery necessitates continuous exploration of new methodology for screening bioactive compounds from TCM. This work intends to establish a strategy for rapidly recognizing β2-adrenergic receptor (β2-AR) target compounds from the fruit of Siraitia grosvenorii (LHG). The method involved immobilization of β2-AR onto amino-microsphere to synthesize the receptor column, the combination of the column to high performance liquid chromatography (HPLC) to screen bioactive compounds of LHG, the identification of the compoun...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Maxime Cormier, Simone Chaboillez, Catherine Lemière
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conditions:   Asthma;   Diabetes Mellitus;   Sickle Cell Disease;   Premature Birth Intervention:   Other: Care Coordination Sponsors:   University of Illinois at Chicago;   Centers for Medicare and Medicaid Services Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Journal of Medical Virology - Category: Virology Authors: Tags: Research Article Source Type: research
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