Let Medicare Negotiate (Editorial)

Last week, Congress proved that it’s still able to get important things done when it reached agreement on a five-year, $305 billion transportation measure to repair and expand highways and other transit infrastructure. It was the first time in 10 years Congress had been able to agree on a long-term highway bill. (See Marty Cook’s Transportation column, Short-Term Nightmare Nears End for Arkansas Highways.) Also last week, the Wall Street Journal published a fascinating, fact- and numbers-heavy article on why prescription drugs cost so much less in Norway than they do in the United States. One example: “A vial of the cancer drug Rituxan cost Norway’s taxpayer-funded health system $1,527 in the third quarter of 2015, while the U.S. Medicare program paid $3,678.” The article found that in the third quarter, U.S. prices were higher for 93 percent of 40 top branded drugs available both here and in Norway. Prescription drug prices are higher in the U.S. than they are in most developed nations. The big difference? Leverage. Norway’s state-run health systems negotiate hard bargains with pharmaceutical companies, “setting price caps, demanding proof of new drugs’ value in comparison to existing ones and sometimes refusing to cover medicines they doubt are worth the cost.” In addition, Norway’s government systems are the only major buyer of prescription drugs, unlike the U.S., where the market consists of employers and insuran...
Source: Arkansas Business - Health Care - Category: American Health Source Type: news

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Publication date: Available online 24 June 2019Source: European UrologyAuthor(s): Yu Wei, Junlong Wu, Weijie Gu, Xiaojian Qin, Bo Dai, Guowen Lin, Hualei Gan, Stephen J. Freedland, Yao Zhu, Dingwei YeAbstractGenetic testing for prostate cancer (PCa) patients is in constant development. Specific genetic alterations indicate personalized managing strategies, requiring clinicians to refer appropriate patients for genetic testing. However, our understanding of genetic epidemiology of PCa is mainly based on data from Caucasian populations. In addition, there is evidence that alterations in DNA repair genes (DRGs) may be ethnic ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 24 June 2019Source: European UrologyAuthor(s): Xiaoling Lin, Brian T. Helfand, Jianfeng Xu
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionCurettage for miscarriage or undesired pregnancy is not exempt from complications, such as hemorrhage, simple perforation, and infection. Intrauterine fallopian tube incarceration is uncommon but can affect fertility. This diagnosis is important to avoid destruction of the fimbriae and necrosis of the tube and also to reduce the risk of ectopic pregnancy.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Authors: Ding W, Li D, Zhang P, Shi L, Dai H, Li Y, Bao X, Wang Y, Zhang H, Deng L Abstract Breast cancer is a highly heterogeneous disease and numerous secreted factors may differentially contribute to a macrophage phenotype whose extensive infiltration is generally regarded as indicative of an unfavorable outcome. How different breast tumor cells and macrophage cells interplay or influence each other on the alternative splicing (AS) level have not been characterized. Here, we exploited one previous study, which investigated the interplay between macrophages and estrogen receptor‑positive (ER+) breast cancer and...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
ConclusionWe conclude that diaphragm interventions are an essential part of CRS. They are associated with increased perioperative morbidity. This morbidity is not attributable to whether the patient underwent diaphragm stripping or resection. However in mesothelioma and LAMNs, requiring diaphragm resection is likely to be an indicator for tumor aggression.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The high levels of endogenous DNA damage in triple ‐negative breast cancer (TNBC) cells makeRECQL5 essential, and therefore a potential drug target against TNBC. AbstractTriple ‐negative breast cancer (TNBC) is a malignancy that currently lacks targeted therapies. The majority of TNBCs can be characterized as basal‐like and has an expression profile enriched with genes involved in DNA damage repair and checkpoint response. Here, we report that TNBC cells are under repl ication stress and are constantly generating DNA double‐strand breaks, which is not seen in non‐TNBC cells. Consequently, we found thatRECQL5, whi...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 22 June 2019Source: Computational and Structural Biotechnology JournalAuthor(s): S. Lu, J. Qian, M. Guo, C. Gu, Y. YangAbstractThyroid Hormone Receptor Interacting Protein 13 (TRIP13) plays a key role in regulating mitotic processes, including spindle assembly checkpoint and DNA repair pathways, which may account for Chromosome instability (CIN). As CIN is a predominant hallmark of cancer, TRIP13 may act as a tumor susceptibility locus. Amplification of TRIP13 has been observed in various human cancers and implicated in several aspects of malignant transformation, including cancer cell pr...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Publication date: Available online 22 June 2019Source: European UrologyAuthor(s): Zsofia Kote-Jarai, Daniel A. Leongamornlert, Edward J. Saunders, David V. Conti, Rosalind A. Eeles
Source: European Urology - Category: Urology & Nephrology Source Type: research
Authors: Di Sante G, Pagé J, Jiao X, Nawab O, Cristofanilli M, Skordalakes E, Pestell RG Abstract Introduction: Collaborative interactions between several diverse biological processes govern the onset and progression of breast cancer. These processes include alterations in cellular metabolism, anti-tumor immune responses, DNA damage repair, proliferation, anti-apoptotic signals, autophagy, epithelial-mesenchymal transition, components of the non-coding genome or onco-mIRs, cancer stem cells and cellular invasiveness. The last two decades have revealed that each of these processes are also directly regulated ...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
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