Zimbabwe: Reflecting On the Aids Pandemic in Zimbabwe

[The Herald] In 1981 a lethal disease was reported among men who have sex with men in New York, Los Angeles and San Francisco in the United States of America. Reports of the disease, which weakened the immune system leading to opportunistic infections such as Kaposi's sarcoma and pneumocystis pneumonia and certain death, appeared in the media including here in Zimbabwe.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news

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Conclusions: Buparlisib was well tolerated, however efficacy was limited despite selection of PI3K pathway aberrations. Future studies may provide insight into buparlisib efficacy by refining the molecular selection of different tumor types. PMID: 31741715 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: Despite the suggested radioresistance of CS, modern radiotherapies may present a treatment option for certain patients. Our results support a role for high-dose, advanced radiation therapies in selected high-risk CS patients with tumors in surgically challenging locations or unplanned positive margins. While there is an associated survival rate benefit, further, prospective studies are needed for validation. PMID: 31736653 [PubMed]
Source: Sarcoma - Category: Cancer & Oncology Tags: Sarcoma Source Type: research
We report a unique case of breast GCT-ST coincident with ductal carcinoma in situ (DCIS), diagnosed with histological, immunohistochemical, and H3F3A (Histone H3.3) mutation analyses. A 59-year-old woman preoperatively diagnosed with DCIS underwent total mastectomy for a cystic mass. Histology revealed a tumor composed of mononuclear cells interspersed with numerous osteoclast-like giant cells, resembling giant cell tumor of bone (GCT-B), with apocrine DCIS in proximity to the tumor. The mononuclear and giant cells were immunoreactive for CD68 and negative for cytokeratins. Granulomatous diseases, carcinomas with giant cel...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This case suggests that breast sarcomas could be treated in the same way as other soft tissue sarcomas in terms of adjuvant chemotherapy.Journal of Medical Case Reports
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
The quilt ’s more than 50,000 panels will move to the National AIDS Memorial, while its archive of personal items will go to the Library of Congress.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Quilts Culture (Arts) Acquired Immune Deficiency Syndrome Archives and Records AIDS Memorial Quilt National AIDS Memorial American Folklife Center Library of Congress the NAMES Project Foundation Golden Gate Park (San Francisco) Source Type: news
This collection of resources has been relaunched for 2019. The campaignurges people to always take their doctor's, pharmacist's or nurse's advice on antibiotics. It provides effective self-care advice to help people and their families feel better if they are not prescribed antibiotics. Antibiotics are essential to treat serious bacterial infections such as pneumonia, meningitis and sepsis. They also help to ward off infections during chemotherapy, caesarean sections and other surgeries. However, while antibiotics are vital to treating life-threatening infections, they are frequently being used to treat less serious illness...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
[Cameroon Tribune] This was during the 11th Ordinary Session of the Scientific Council of the Research Centre yesterday, November 19, 2019 in Yaounde.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
In conclusion, the critical role of DLX6-AS1 might unveil a potential therapeutic target for Ewing's sarcoma. PMID: 31737208 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Authors: He P, Guo Y, Wang J, Yan L, Feng A Abstract Pneumonia is a major cause of morbidity and mortality of infectious diseases, especially in children. Ripasudil (K-115), a selective ROCK inhibitor, is a promising emerging drug against glaucoma, and reported to have anti-inflammatory activity. However, the anti-inflammatory effect of ripasudil still remains unclear in pneumonia. The goal of this study is to investigate the role and the underlying mechanism of ripasudil in pneumonia. BALB/c mice were used to establish an acute pneumonia model of mice by injection of lipopolysaccharide (LPS) intraperitoneally. Rip...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Wiebke Hartmann, Marie-Luise Brunn, Nadine Stetter, Nicola Gagliani, Franziska Muscate, Stephanie Stanelle-Bertram, Gülsah Gabriel, Minka BreloerSummaryHelminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seaso...
Source: Cell Reports - Category: Cytology Source Type: research
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