Antimicrobial resistance: one world, one fight!

Abstract The lack of new antibiotic classes calls for a cautious use of existing agents. Yet, every 10 min, almost two tons of antibiotics are used around the world, all too often without any prescription or control. The use, overuse and misuse of antibiotics select for resistance in numerous species of bacteria which then renders antimicrobial treatment ineffective. Almost all countries face increased antimicrobial resistance (AMR), not only in humans but also in livestock and along the food chain. The spread of AMR is fueled by growing human and animal populations, uncontrolled contamination of fresh water supplies, and increases in international travel, migration and trade. In this context of global concern, 68 international experts attending the fifth edition of the World HAI Resistance Forum in June 2015 shared their successes and failures in the global fight against AMR. They underlined the need for a “One Health” approach requiring research, surveillance, and interventions across human, veterinary, agricultural and environmental sectors. This strategy involves concerted actions on several fronts. Improved education and increased public awareness are a well-understood priority. Surveillance systems monitoring infections need to be expanded to include antimicrobial use, as well as the emergence and spread of AMR within clinical and environmental samples. Adherence to practices to prevent and control the spread of infections is mandatory to redu...
Source: Antimicrobial Resistance and Infection Control - Category: Infectious Diseases Source Type: research

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ConclusionTo our knowledge, this is the first report on complete nucleotide sequences of type 2 IncC plasmids. These findings, which hypothesise the acquisition of KPC-2-encoding transposon Tn4401a by an IncC replicon, indicate the ongoing need for molecular surveillance studies of multidrug-resistant pathogens. In addition, they underline the increasing clinical importance of the IncC plasmid family.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 20 September 2019Source: The Lancet Global HealthAuthor(s): Elizabeth Tayler, Richard Gregory, Gerry Bloom, Peter Salama, Hanan Balkhy
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
ConclusionMultidrug resistance was higher among HLGR and HLSR isolates compared to non-HLGR and non-HLSR isolates which is a concern because it results in limitation of treatment choices. More than 50% of the isolates were sensitive to aminoglycosides; hence correct identification in clinical laboratories and administration of these antibiotics can result in decrease of antibiotics such as Vancomycin and Linezolid and help to reduce the emergence of resistance to these drugs.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsIn conclusion, it would appear that the most prevalent mcr gene of E. coli from diarrheic weaned piglets in Korea was mcr-3. And, to our best knowledge, this is the first report for coexistence of two plasmid-mediated colistin resistance genes, mcr-1 and mcr-3 in the same isolates (0258, 0491, 0516) from piglets with diarrhea in Korea. Those mcr–positive isolates showed multi-drug resistance, and majority of those encoded Stx2e and F18. This indicates that the risk of inefficient treatment for edema disease in weaned piglets.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 September 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Alexsandra Maria Lima Scavuzzi, Elizabeth Maria Bispo Beltrão, Elza Ferreira Firmo, Érica Maria de Oliveira, Fernanda Gomes Beserra, Ana Catarina de Souza Lopes
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Conclusion: Our results show a substantial increase in the direct medical costs of patients with urinary tract infections caused by beta-lactam-resistant Gram-negative bacilli (cephalosporins and carbapenems). This situation is of particular concern in endemic countries such as Colombia, where the high frequencies of urinary tract infections and the resistance to beta-lactam antibiotics can generate a greater economic impact on the health sector. PMID: 31529847 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Commentary Source Type: research
Nature, Published online: 20 September 2019; doi:10.1038/d41586-019-02861-5Drug-resistant bacteria are gaining a stronghold in developing countries where meat production has soared.
Source: Nature AOP - Category: Research Authors: Source Type: research
Acinetobacter baumannii is one of the most important nosocomial pathogens distributed worldwide. Due to its multidrug-resistance and the propensity for the epidemic spread, the World Health Organization includes this bacterium as a priority health issue for development of new antibiotics. The aims of this study were to investigate the antimicrobial resistance profile, the clonal relatedness, the virulence profiles, the innate host immune response and the clonal dissemination of A. baumannii in Hospital Civil de Guadalajara (HCG), Hospital Regional General Ignacio Zaragoza (HRGIZ) and Pediatric ward of the Hospital General ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionPatients in different European countries do not have the same preferences for the attributes of diagnostic tests to manage AMR in primary care. Failure to account for such differences during test development could reduce test uptake, result in continued overuse of antibiotics, and hamper marketisation.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
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