SPOP the mutation

Prostate cancers with mutations to a protein called SPOP use an error-prone method to repair broken DNA strands.
Source: eLife - Category: Biomedical Science Authors: Tags: Prostate cancer Source Type: research

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In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ligands...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
CONCLUSION: Our findings indicate that the number of γH2AX foci per cell was not changed in dependence on the Ra-223 therapy cycles. The ability of patient's lymphocytes to repair ex vivo induced DSB remained unaffected throughout the entire therapy course. PMID: 31387125 [PubMed - as supplied by publisher]
Source: Nuklearmedizin - Category: Radiology Authors: Tags: Nuklearmedizin Source Type: research
Conclusion: PC patients carrying ≥1 pathogenic DNA instability mutation, and DRD mutation carriers specifically, had higher clinical burden than non-mutation carriers. Targeted therapies for these patients are needed to reduce clinical burden and associated healthcare resource utilization. PMID: 31352849 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Publication date: Available online 26 July 2019Source: European UrologyAuthor(s): Daniel McLennan, Niranjan Sathianathen, Omar Alghazo, Arun Azad, Declan G. Murphy
Source: European Urology - Category: Urology & Nephrology Source Type: research
Genes, Vol. 10, Pages 565: PARP Inhibitors in Prostate Cancer–the Preclinical Rationale and Current Clinical Development Genes doi: 10.3390/genes10080565 Authors: Verneri Virtanen Kreetta Paunu Johanna K. Ahlskog Reka Varnai Csilla Sipeky Maria Sundvall Prostate cancer is globally the second most commonly diagnosed cancer type in men. Recent studies suggest that mutations in DNA repair genes are associated with aggressive forms of prostate cancer and castration resistance. Prostate cancer with DNA repair defects may be vulnerable to therapeutic targeting by Poly(ADP-ribose) polymerase (PARP) inhibit...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
Genes, Vol. 10, Pages 565: PARP Inhibitors in Prostate Cancer—The Preclinical Rationale and Current Clinical Development Genes doi: 10.3390/genes10080565 Authors: Virtanen Paunu Ahlskog Varnai Sipeky Sundvall Prostate cancer is globally the second most commonly diagnosed cancer type in men.Recent studies suggest that mutations in DNA repair genes are associated with aggressive forms ofprostate cancer and castration resistance. Prostate cancer with DNA repair defects may bevulnerable to therapeutic targeting by Poly(ADPÔÇÉribose) polymerase (PARP) inhibitors. PARPenzymes modify target proteins...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
Abstract Inter- and intra-patient molecular heterogeneity of primary and metastatic prostate cancer (PCa) confers variable clinical outcome and poses a formidable challenge in disease management. High-throughput integrative genomics and functional approaches have untangled the complexity involved in this disease and revealed a spectrum of diverse aberrations prevalent in various molecular subtypes, including ETS fusion negative. Emerging evidence indicates that SPINK1 upregulation, mutations in epigenetic regulators or chromatin modifiers, and SPOP are associated with the ETS-fusion negative subtype. Additionally,...
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research
Publication date: Available online 22 July 2019Source: European UrologyAuthor(s): Alec Paschalis, Beshara Sheehan, Ruth Riisnaes, Daniel Nava Rodrigues, Bora Gurel, Claudia Bertan, Ana Ferreira, Maryou B.K. Lambros, George Seed, Wei Yuan, David Dolling, Jon C. Welti, Antje Neeb, Semini Sumanasuriya, Pasquale Rescigno, Diletta Bianchini, Nina Tunariu, Suzanne Carreira, Adam Sharp, Wim OyenAbstractBackgroundProstate-specific membrane antigen (PSMA; folate hydrolase) prostate cancer (PC) expression has theranostic utility.ObjectiveTo elucidate PC PSMA expression and associate this with defective DNA damage repair (DDR).Design...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 22 July 2019Source: SteroidsAuthor(s): Xiaoting Ma, Anindita Biswas, Stephen R. HammesAbstractPaxillin is extensively involved in focal adhesion signaling and kinase signaling throughout the plasma membrane and cytoplasm. However, recent studies in prostate cancer suggest that paxillin also plays a critical role in regulating gene expression within the nucleus, serving as a liaison between cytoplasmic and nuclear MAPK and Androgen Receptor (AR) signaling. Here we used RNA-seq to examine the transcriptome in several human prostate cancer cell lines. First, we examined paxillin effects on a...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
More News: Biomedical Science | Cancer | Cancer & Oncology | Gastroschisis Repair | Prostate Cancer