Resistance integrons: class 1, 2 and 3 integrons
As recently indiscriminate abuse of existing antibiotics in both clinical and veterinary treatment leads to proliferation of antibiotic resistance in microbes and poses a dilemma for the future treatment of such bacterial infection, antimicrobial resistance has been considered to be one of the currently leading concerns in global public health, and reported to widely spread and extended to a large variety of microorganisms. In China, as one of the currently worst areas for antibiotics abuse, the annual prescription of antibiotics, including both clinical and veterinary treatment, has approaching 140 gram per person and been roughly estimated to be 10 times higher than that in the United Kingdom, which is considered to be a potential area for the emergence of “Super Bugs”. Based on the integrons surveillance in Guangzhou, China in the past decade, this review thus aimed at summarizing the role of integrons in the perspective of both clinical setting and environment, with the focus on the occurrence and prevalence of class 1, 2 and 3 integrons.
ConclusionTo our knowledge, this is the first report on complete nucleotide sequences of type 2 IncC plasmids. These findings, which hypothesise the acquisition of KPC-2-encoding transposon Tn4401a by an IncC replicon, indicate the ongoing need for molecular surveillance studies of multidrug-resistant pathogens. In addition, they underline the increasing clinical importance of the IncC plasmid family.
Publication date: Available online 20 September 2019Source: The Lancet Global HealthAuthor(s): Elizabeth Tayler, Richard Gregory, Gerry Bloom, Peter Salama, Hanan Balkhy
ConclusionMultidrug resistance was higher among HLGR and HLSR isolates compared to non-HLGR and non-HLSR isolates which is a concern because it results in limitation of treatment choices. More than 50% of the isolates were sensitive to aminoglycosides; hence correct identification in clinical laboratories and administration of these antibiotics can result in decrease of antibiotics such as Vancomycin and Linezolid and help to reduce the emergence of resistance to these drugs.
ConclusionsIn conclusion, it would appear that the most prevalent mcr gene of E. coli from diarrheic weaned piglets in Korea was mcr-3. And, to our best knowledge, this is the first report for coexistence of two plasmid-mediated colistin resistance genes, mcr-1 and mcr-3 in the same isolates (0258, 0491, 0516) from piglets with diarrhea in Korea. Those mcr–positive isolates showed multi-drug resistance, and majority of those encoded Stx2e and F18. This indicates that the risk of inefficient treatment for edema disease in weaned piglets.
Publication date: Available online 19 September 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Alexsandra Maria Lima Scavuzzi, Elizabeth Maria Bispo Beltrão, Elza Ferreira Firmo, Érica Maria de Oliveira, Fernanda Gomes Beserra, Ana Catarina de Souza Lopes
Conclusion: Our results show a substantial increase in the direct medical costs of patients with urinary tract infections caused by beta-lactam-resistant Gram-negative bacilli (cephalosporins and carbapenems). This situation is of particular concern in endemic countries such as Colombia, where the high frequencies of urinary tract infections and the resistance to beta-lactam antibiotics can generate a greater economic impact on the health sector. PMID: 31529847 [PubMed - in process]
Nature, Published online: 20 September 2019; doi:10.1038/d41586-019-02861-5Drug-resistant bacteria are gaining a stronghold in developing countries where meat production has soared.
Acinetobacter baumannii is one of the most important nosocomial pathogens distributed worldwide. Due to its multidrug-resistance and the propensity for the epidemic spread, the World Health Organization includes this bacterium as a priority health issue for development of new antibiotics. The aims of this study were to investigate the antimicrobial resistance profile, the clonal relatedness, the virulence profiles, the innate host immune response and the clonal dissemination of A. baumannii in Hospital Civil de Guadalajara (HCG), Hospital Regional General Ignacio Zaragoza (HRGIZ) and Pediatric ward of the Hospital General ...
ConclusionPatients in different European countries do not have the same preferences for the attributes of diagnostic tests to manage AMR in primary care. Failure to account for such differences during test development could reduce test uptake, result in continued overuse of antibiotics, and hamper marketisation.