Management of Central Poststroke Pain: Systematic Review of Randomized Controlled Trials Clinical Sciences

Conclusions— Our findings are inconsistent with major clinical practice guidelines; the available evidence suggests no beneficial effects of any therapies that researchers have evaluated in randomized controlled trials.
Source: Stroke - Category: Neurology Authors: Tags: Other Treatment, Other Stroke Clinical Sciences Source Type: research

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Purpose of review Red cell transfusions are one of the most common and important therapies used for patients with sickle cell disease (SCD). For prevention of strokes, there is abundant evidence that transfusions are efficacious, whereas for other indications, such as prevention of pain, there are less data. Nonetheless, with few therapeutic options, the use of transfusion for prevention of acute pain has increased in children and adults with SCD without a clear understanding of its benefits. Recent findings Although it makes conceptual sense that red cell transfusions would prevent pain that arises from vaso-occlusio...
Source: Current Opinion in Hematology - Category: Hematology Tags: TRANSFUSION MEDICINE AND IMMUNOHEMATOLOGY: Edited by Steven L. Spitalnik Source Type: research
Publication date: Available online 30 September 2019Source: Neuroscience LettersAuthor(s): Hirotake Yokota, Naofumi Otsuru, Rie Kikuchi, Rinako Suzuki, Sho Kojima, Kei Saito, Shota Miyaguchi, Yasuto Inukai, Hideaki OnishiAbstractTwo-point discrimination (TPD) has been widely used as a parameter for the examination of higher-order perceptual functions in the field of rehabilitation. Previous research has shown that the threshold of TPD increases with aging or pathological conditions such as stroke or chronic pain. It has also been reported that the threshold can be decreased by continuous tactile or electrical stimulation. ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Conclusions: The FGA is a clinical measure of functional gait performance that reflected spatiotemporal gait parameters and ability of individuals with chronic stroke to live independently. The FGA could be used to target interventions to improve functional gait performance of individuals with chronic stroke.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Research Reports Source Type: research
Genu recurvatum (GR) in persons who are post-stroke can lead to excessive peak knee extension (>5 degrees) during the stance phase of gait. If untreated, GR can contribute to knee instability, weakness, osteoarthritis, and chronic pain. The purpose of this study was to investigate the effect of combining a heel lift with an ankle-foot orthosis (AFO) on genu recurvatum during gait in persons who are post-stroke. We hypothesized that the heel lift would result in a decrease in peak knee extension during the stance phase of gait.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Source Type: research
We read with great interest the recent letter sent to you by McConnell and colleagues [1], in which they discuss one of the first applications of truly independent home-based electrical brain stimulation, applied following safety recommendations. Transcranial direct-current stimulation (tDCS) is a non-invasive brain stimulation technique capable of modulating cortical excitability beyond the stimulation period [2,3]. tDCS presents interesting options as a therapeutic intervention in multiple neurological disorders, such as stroke, depression, chronic pain, schizophrenia, and Alzheimer ’s and Parkinson’s disease [4,5].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Conclusions: Self-reported pre-sleep somatic symptoms are a marker of comorbid anxiety and, potentially chronic pain, impacting nighttime sleep. The optimal cutoff scores of 14 and 20 proposed herein can help clinicians with case formulation, with tailoring BSM treatments and their targets. PMID: 31545084 [PubMed - as supplied by publisher]
Source: Behavioral Sleep Medicine - Category: Sleep Medicine Authors: Tags: Behav Sleep Med Source Type: research
Authors: Riepl R, Hoffmann TK, Goldberg-Bockhorn E, Richter P, Reiter R Abstract Dysphagia is a common symptom and can be indicative of a variety of heterogeneous diseases. "Classical" diseases of the head and neck region, such as acute tonsillitis, peritonsillar abscesses, diverticula, and benign or malignant tumors are common causes of dysphagia. However, it can also occur in the context of neurological diseases, e.g., as a result of stroke or as an age-related phenomenon (presbyphagia). Pathologies of the cervical spine can also be a cause of dysphagia. In this context, congenital o...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
Discussion: Our findings indicate that the diagnostic validity of the current Budapest clinical criteria for PS-CRPS is low. Thus, the current Budapest criteria might not be appropriate for PS-CRPS diagnosis.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick with...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractPurpose of ReviewThe long-term use of opioid and cannabinoid medications to control chronic pain and treat opioid use disorders now involves a large proportion of the population in the United States. Yet, the cardiovascular risks of opioids are not well understood. This systematic review summarizes the current literature to assess the potential cardiovascular disease risks associated with opioid and cannabinoid medications.Recent FindingsThe role of long-term methadone use in increasing QT interval among people receiving methadone treatment for substance use disorders is well established. Routine electrocardiogram ...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
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