Tobacco Use and Outcomes in Gynecologic Malignancy

Abstract Tobacco use remains a significant cause of morbidity and mortality worldwide. Tobacco contains many carcinogens as well as nicotine, which contributes to the development of multiple malignancies. In addition to malignancies of the head and neck, several gynecologic malignancies have been associated with tobacco use including cervical, vulvar, and vaginal cancers. Additionally, tobacco is associated with worse prognosis and increased rate of complications in gynecologic cancer patients of all disease sites. Recent literature in the area of tobacco use and gynecologic malignancy is highlighted in this review including tobacco’s association with treatment complications, secondary malignancy, and surgical complications. A focus is placed on tobacco cessation as a means to improve these outcomes. The use of automated referrals to reduce provider burden and targeting of the preoperative window are valuable strategies. Smoking cessation should be encouraged by oncologists and survivorship programs as a means to improve the health of women with gynecologic malignancy and reduce healthcare costs.
Source: Current Obstetrics and Gynecology Reports - Category: OBGYN Source Type: research

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Dalton Trans., 2019, Advance Article DOI: 10.1039/C9DT03221E, PaperBiyun Sun, Madhu K. Sundaraneedi, Hannah M. Southam, Robert K. Poole, Ian F. Musgrave, F. Richard Keene, J. Grant Collins The non-linear polypyridylruthenium(II) complex (Rubb7-TNL) exhibited good antimicrobial activity, but surprisingly was also highly active against cancer cells. The results suggestRubb7-TNL may have potential as a new anticancer agent. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
[The Herald] Health and Child Care Ambassador, First Lady Auxillia Mnangagwa yesterday commended the National Aids Council of Zimbabwe for donating cervical cancer screening machines to the Ministry of Health and Child Care.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionsIL17RB predicts the prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
In this study, we investigated the cytotoxic effect of cisplatin, a clinical chemotherapeutic for cervical cancer treatment, on parental and spheroid CVC cells and surveyed the effect of LncRNA on drug-resistance. We found that spheroid CVC cells showed much more resistant to cisplatin-induced cytotoxicity compared with parental CVC cells. Furthermore, cisplatin significantly induced apoptotic cell death, while it induced cell cycle arrest in G0/G1 phase at the same dose (10 μg/ml). We also found the significant expression of EGFR in spheroid instead of parental CVC cells. Interestingly, we revealed that protrudi...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Yoo Jin Lee, Harim Oh, Eojin Kim, Bokyung Ahn, Jeong Hyeon Lee, Youngseok Lee, Yang Seok Chae, Sung Gu Kang, Chul Hwan KimAbstractHOXA transcript at the distal tip (HOTTIP) is a long noncoding RNA (lncRNA), which is>200 nucleotides in length. HOTTIP expression has been demonstrated to play a crucial oncogenic role in cancer pathogenesis, and is said to be associated with poor human cancer prognosis. In prostate cancer, HOTTIP has been identified as an oncogene, but its clinicopathologic significance remains unclear. A...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 September 2019Source: Pathology - Research and PracticeAuthor(s): Banita Thakur, Yashwant Kumar, Alka BhatiaAbstractBreast cancer is one of the major causes of cancer related deaths in women worldwide. A major factor responsible for treatment failure in breast cancer is the development of resistance to commonly used chemotherapeutic drugs leading to disease relapse. Several studies have shown dysregulation of molecular machinery of apoptosis, the major programmed cell death pathway in breast malignancies. Thus, there is an unmet need to search for an alternative cell death pathway whic...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 17 September 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Virginia Benito, Amina Lubrano, Miguel Andújar, Marta Mori, Mario FedericoAbstractObjectiveThe goal of this study was to evaluate the demographic characteristics, pathology, treatment, prognostic factors and survival rates in elderly patients with endometrial cancer, and to compare their results with those of younger ones, in order to define the specific characteristics of this malignancy in this population.Study design: Retrospective analysis of all endometrial cancer patient...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 17 September 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Emily Han-Chung Hsiue, Pei-Lin Lee, Yung-Hsuan Chen, Chong-Jen Yu
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
ConclusionsAnal and vulval cancers have increased over the reporting period. There is need to continuously monitor trends of these cancers. Implementation of HPV vaccination could significantly reduce the burden of HPV-related cancers.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Human papillomaviruses (HPV) are responsible for the development of almost all cervical cancers. HPV is also found in 85% of anal cancer and in 50% of penile, vulvar, and vaginal cancers, and they are increasingly found in a subset of head and neck cancers, i.e., oropharyngeal squamous cell carcinomas (OPSCC). The model for how HPV causes cancer is derived from several decades of study on cervical cancer, and it is just presumed that this model is not only completely valid for cervical cancer but for all other HPV-driven cancers as well. Next-generation sequencing (NGS) has now provided the necessary tools to characterize ...
Source: Cytogenetic and Genome Research - Category: Genetics & Stem Cells Source Type: research
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