Exercise training for managing behavioral and psychological symptoms in people with dementia: a systematic review and meta-analysis.

In conclusion, exercise reduces depression levels in PWD. Future studies should examine whether exercise reduces the use (and doses) of antipsychotics and other drugs often used to manage BPSD. PMID: 26369357 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research

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Testing for Alzheimer ’s disease and other forms of dementia is hardly foolproof, and could even backfire.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer ' s Disease Families and Family Life Memory Elderly Dementia Genetics and Heredity Anxiety and Stress Living Wills and Health Care Proxies Diet and Nutrition Depression (Mental) Frontotemporal Dementia Brain Nursing H Source Type: news
DiscussionWe hypothesize that caregivers in the screening arms will express higher levels of health-related quality of life, lower depressive and anxiety symptoms, and better preparation for caregiving with higher self-efficacy at 24  months. Results from this study will directly inform the National Plan to Address Alzheimer’s Disease, the USPSTF and other organizations regarding ADRD screening and early detection policies.Trial registrationClinicalTrials.gov,NCT03300180. Registered on 3 October.
Source: Trials - Category: Research Source Type: clinical trials
Dementia with Lewy bodies (DLB) is the second most common form of dementia in the elderly, and various clinical symptoms, including olfactory dysfunction, dysautonomia, depression, and rapid eye movement sleep behavior disorders (RBD), occur in patients with the prodromal state of DLB. We herein describe a case of a 72-years-old right-handed woman who exhibited primary progressive aphasia (PPA) as a prodromal state of DLB and took cholinesterase inhibitors (donepezil). At 4.5 years after aphasia onset, she exhibited all the core clinical features of DLB, including visual hallucinations, fluctuating cognition, RBD, and Park...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
To investigate whether strength or aerobic training can offer significantly more benefits with regards to the activities of daily living of elderly patients with dementia, as well as to determine the effects of exercise on cognition, depression, and biochemical markers.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Source Type: research
Along with cognitive decline, 90% of patients with dementia experience behavioral and psychological symptoms of dementia, such as psychosis, aggression, agitation, and depression. Atypical antipsychotics are commonly prescribed off-label to manage certain ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Abstract BACKGROUND: The significance of palliative care consultation in psychiatry is unclear. ACTUAL CASE SERIES: Analysis of the introduction of palliative care consultation in a large psychiatric hospital. POSSIBLE COURSES OF ACTION: Continue without offering, survey the need for or offer palliative care consultation, and analyse its introduction. FORMULATION OF A PLAN: Palliative care consultation was established and details including patient age, department, diagnosis, main problem, solution and discharge were analysed during the first 2 years. OUTCOME: Two consultations in the fir...
Source: Palliative Medicine - Category: Palliative Care Authors: Tags: Palliat Med Source Type: research
Publication date: Available online 15 February 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Filip Kosel, Jessica M.S. Pelley, Tamara B. FranklinAbstractTransgenic mouse models have been used extensively to model the cognitive impairments arising from Alzheimer’s disease (AD)-related pathology. However, less is known about the relationship between AD-related pathology and the behavioural and psychological symptoms of dementia (BPSD) commonly presented by patients. This review discusses the BPSD-like behaviours recapitulated by several mouse models of AD-related pathology, including the APP/PS1, Tg2576...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
ski J Abstract The majority of research works to date suggest that major depressive disorder (MDD) is a risk factor for dementia and may predispose to cognitive decline in both early and late onset variants. The presence of depression may not, however, reflect the cause, rather, an effect: it may be a response to cognitive impairment or alters the threshold at which cognitive impairment might manifest or be detected. An alternative hypothesis is that depression may be part of a prodrome to Alzheimer's disease (AD), suggesting a neurobiological association rather than one of psychological response alone. Genetic po...
Source: Current Alzheimer Research - Category: Neurology Authors: Tags: Curr Alzheimer Res Source Type: research
You notice your loved one becoming more forgetful. She cannot recall her visit with her granddaughters yesterday. She claims she took her medications this morning, yet you find them untouched in her pill case. You wonder how this mild-mannered woman has become so angry, so quickly. She is often frightened now, disoriented, and unpredictable. Yet she still remembers every detail of your wedding day, the names of your four children, and how to play her favorite piano pieces. When you sing together, time temporarily stands still. Your loved one received a diagnosis of Alzheimer’s disease. Nights are the hardest time for...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Caregiving Healthy Aging Memory Source Type: blogs
This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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