Nigeria: Meningitis Epidemic Looms Over Vaccine Shortage

[Independent (Lagos)] Lagos -There is palpable fear among health officials in the country following an alert on the possibility of a meningitis epidemic.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

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Authors: Christopher GW Abstract Meningococcal epidemics at 2 training facilities were early examples of outbreaks fueled by military demographics and because of lethal drug-resistant bacteria for which there are no vaccines or chemoprophylaxis. Positive outcomes included the elucidation of the natural history of meningococcal colonization and disease and the initiation of vaccine development. PMID: 32591792 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
The global burden of bacterial meningitis (BM) remains high even with improving coverage of conjugate vaccines (GBD Meningitis Collaborators, 2018). Although the incidence, aetiology, and outcome vary by age and region (Edmond et al., 2010; GBD Meningitis Collaborators, 2018; Oordt-Speets et al., 2018), the burden is heaviest in Sub-Saharan Africa where the problem is related to poverty (GBD Meningitis Collaborators, 2018). Outside Neisseria meningitidis epidemics, the peak age of BM is in the neonatal period (GBD Meningitis Collaborators, 2018; Heath et al.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Afraid of Covid-19, parents are postponing well-child checkups, including shots, putting millions of children at risk of exposure to preventable deadly diseases.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Vaccination and Immunization Measles Whooping Cough Mumps Diphtheria Coronavirus (2019-nCoV) Babies and Infants Preventive Medicine Epidemics Meningitis your-feed-healthcare Source Type: news
This study aimed to investigate the genetic diversity of recent invasive meningococci in Turkey with respect to multilocus sequence type (MLST) and also meningococcal serogroup B (MenB) vaccine antigens to enable assessment of potential MenB strain coverage using the genetic Meningococcal Antigen Typing System (gMATS). Fifty-four isolates, representing 37.5% of all pediatric (ages 0-18 years) invasive meningococcal disease cases in Turkey from January 2013 to December 2017, underwent genome sequence analysis. Thirty-six (66.7%) isolates were MenB, 10 (18.5%) were serogroup W (MenW), 4 (7.4%) were serogroup A (MenA), 3...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Neisseria meningitidis (The meningococcus, Men) is a Gram-negative bacterium that cause meningitis and/or septicaemia. The virulence of Men is linked to many bacterial factors but the major one is the capsule. Based on the structure and the expression of the capsule, meningococcal strains are classified into 12 serogroups but Invasive Meningococcal Disease (IMD) is linked almost only to six of them: A, B, C, W, Y or X causing sporadic cases, small clusters or epidemics all over the world. However, the distribution of meningococcal serogroups varies in time and from country to another (Acevedo et al., 2019).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Neisseria meningitidis (meningococcus, Men) is a gram-negative bacterium that causes meningitis and/or septicaemia. The virulence of Men is linked to many bacterial factors, but the major one is the capsule. Meningococcal strains are classified into 12 serogroups based on the structure and the expression of the capsule, but invasive meningococcal disease (IMD) is generally associated with only six of them: A, B, C, W, Y, and X; these cause sporadic cases, small clusters, and epidemics worldwide.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Carter Roberts’ motorized wheelchair didn’t arrive until the day he died. It had been a long time coming and his parents had fought hard to get it. The chair cost more than $32,000 and the insurance companies wouldn’t cover it, so the family went to court. One insurer eventually agreed to pay for some components of the chair but not the whole thing. And then none of it mattered anyway. On Sept. 22, 2018, the Roberts’ doorbell rang and the chair was delivered. Also on Sept. 22, 2018, Carter died, just three months shy of his sixth birthday. He had been largely paralyzed for the final two years of his...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease viruses Source Type: news
AbstractNeisseria meningitidis is a major cause of meningitis and septicemia with cases, outbreaks, and epidemics reported globally in industrialized and non-industrialized countries.N. meningitidis is categorized into 12 serogroups; however, only 5 serogroups (A, B, C, W, Y) are responsible for the majority of disease. Invasive meningococcal disease (IMD) occurs unpredictably; protection is therefore best achieved by initiating proactive vaccination strategies. Vaccines are currently available for the five main disease-causing serogroups. With the evolution of meningococcal vaccines and changes in IMD epidemiology, differ...
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research
Jean-Philippe Auger, Anaïs-Christelle Boa, Mariela Segura and Marcelo Gottschalk* Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Disease Research Center (CRIPA), Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada Streptococcus suis is an important porcine bacterial pathogen and a zoonotic agent causing a variety of pathologies including sudden death, septic shock, and meningitis. Though serotype 2 is the most studied serotype due to its presence worldwide, serotype 9 is responsible for the greatest number of porcine cases...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Vega Masignani1, Mariagrazia Pizza1 and E. Richard Moxon2* 1GSK Vaccines, Siena, Italy 2Department of Pediatrics, Oxford University, Oxford, United Kingdom The discovery of vaccine antigens through whole genome sequencing (WGS) contrasts with the classical hypothesis-driven laboratory-based analysis of microbes to identify components to elicit protective immunity. This radical change in scientific direction and action in vaccine research is captured in the term reverse vaccinology. The complete genome sequence of an isolate of Neisseria meningitidis serogroup B (MenB) was systematically analyzed to identify prot...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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