Ceftaroline activity tested against contemporary Latin American bacterial pathogens (2011).

Ceftaroline activity tested against contemporary Latin American bacterial pathogens (2011). Braz J Infect Dis. 2014 Feb 7; Authors: Flamm RK, Sader HS, Jones RN Abstract A total of 2484 target bacterial pathogens were collected (one per patient episode) from patients in 16 Latin American medical centers located in seven nations during 2011. Isolate identity was confirmed at a coordinating laboratory and susceptibility testing was performed for ceftaroline and comparator agents according to reference broth microdilution methods. A total of 30.0% of isolates were from respiratory tract, 29.4% from skin and skin structure, 21.4% from blood stream, 7.9% from urinary tract and 11.3% from other sites. Ceftaroline was active against Staphylococcus aureus (42.8% MRSA) with 83.6% of the isolates at ≤1mg/L and all isolates at ≤2mg/L (MIC5090, 0.25/2mg/L). National MRSA rates ranged from a low 28.8% in Colombia to a high 68.1% in Chile. All Streptococcus pyogenes and Streptococcus agalactiae were susceptible to ceftaroline (MIC50/90 values were at ≤0.015/0.015mg/L for both). All Streptococcus pneumoniae were susceptible to ceftaroline, linezolid, tigecycline and vancomycin. Susceptibility to ceftriaxone was at 88.4% (CLSI non-meningitis interpretive criteria) and 73.9% (CLSI meningitis interpretive criteria) for all S. pneumoniae. Ceftriaxone susceptibility was only at 33.3% (CLSI non-meningitis interpretive criteria) and 0.0% (CLSI meningitis interpretive crit...
Source: Braz J Infect Dis - Category: Infectious Diseases Authors: Tags: Braz J Infect Dis Source Type: research

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Discussion Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males. GBS usually occurs 2-4 weeks after a prodromal gastroenteritis or respiratory illness. GBS causes autoantibody production against Schwann cells of the neuron and the axon itself. There is ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Publication date: Available online 18 November 2018Source: Food Research InternationalAuthor(s): Wenliang Xiang, Kekun Lu, Nandi Zhang, Qianwen Lu, Qin XuAbstractThe organic agricultural products has been growing rapidly in recent years. However, a potential food safe risk, resulted by introduction more antibiotic resistant genes (ARGs) accompanied with animal manure using to organic farming, has long been overlooked. In current study, the bacterial community, 22 tetracycline, 3 aminoglycoside and 4 β-lactams ARGs were respectively investigated in the organic, chemical and wild Houttuynia cordata Thunb (HCT). A total ...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: 25 April 2019Source: Food Chemistry, Volume 278Author(s): Sourav Das, Zoltán Gazdag, Lajos Szente, Mátyás Meggyes, Györgyi Horváth, Beáta Lemli, Sándor Kunsági-Máté, Mónika Kuzma, Tamás KÅ‘szegiAbstractFree essential oils and their active components have a low physiochemical stability and low aqueous solubility which limit their applications as food preservatives and in packaging industry. The aim of this study was to characterize the physicochemical properties, antioxidant activities and antimicrobial activity of randomly m...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 17 November 2018Source: Molecular and Biochemical ParasitologyAuthor(s): Jingyi Liu, Zhirong Fu, Lars Hellman, Staffan G. SvärdAbstractGiardia intestinalis is a protozoan parasite and the causative agent of giardiasis, a common diarrheal disease. Cysteine protease (CP) activities have been suggested to be involved in Giardia’s pathogenesis and we have recently identified and characterized three secreted Giardia CPs; CP14019, CP16160 and CP16779. Here we have studied the cleavage specificity of these CPs using substrate phage display and recombinant protein substrates. The phage...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
In this study, the porcine GM-CSF (pGM-CSF) and FliC protein were expressed by pSUMO in E.coli Rosetta (DE3) and purified by Ni-NTA Sepharose, respectively. The immunogenicity of PCV vaccine with pGM-CSF and FliC was firstly evaluated to identify the immunoenhancement in mice. The results indicated that mice immunized with vaccine + pGM-CSF + FliC enhanced immune responses ability significantly and quickly. Then, the immune response level of PCV vaccine with pGM-CSF and FliC was assessed in piglets. The results indicated that pigs immunized with vaccine + pGM-CSF + Fl...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 17 November 2018Source: Journal of Structural BiologyAuthor(s): Olga I Antimonova, Dmitry V Lebedev, Yana A Zabrodskaya, Natalia A Grudinina, Andrey L Timkovsky, Edward Ramsay, Michael M Shavlovsky, Vladimir V EgorovAbstractIn a number of conformational diseases, intracellular accumulation of proteins bearing non-native conformations occurs. The search for compounds that are capable of hindering the formation and accumulation of toxic protein aggregates and fibrils is an urgent task. Present fluorescent methods of fibrils’ detection prevent simple real-time observations. We suppose ...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Publication date: Available online 17 November 2018Source: Carbohydrate PolymersAuthor(s): Zongbao Zhou, Tao Chen, Naibin Mei, Bing Li, Zunkai Xu, Lei Wang, Xiaoying Wang, Shunqing TangAbstractThe rapid emergence of antibiotic-resistant Gram-negative bacteria (GNB) is becoming a global healthcare concern, and it urgently needs novel strategies to match the clinical challenge. In this work, we conjugated chitosan (CS) with LED 209, a highly selective inhibitor of QseC of GNB, to create the novel selective antimicrobial agent CS/LED. The data of FT-IR, NMR and elemental analysis for CS/LED conjugates proved the successful co...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: 25 March 2019Source: Journal of Alloys and Compounds, Volume 778Author(s): Mozhgan Salehi, Akbar Eshaghi, Hamid TajizadeganAbstractA shell of ZnCr2O4 spinel was facilely covered on the surface of TiO2 nanoparticles to synthesize TiO2/ZnCr2O4 core-shell structure using TiO2 seed particles and heterogeneous precipitation. The as-prepared nanocomposite was characterized in terms of crystal structure, morphology and surface area, light absorption and band gap. After coupling TiO2 with ZnCr2O4, a heterojunction formed between the two semiconductor materials. UV–vis absorption spectra showed a red shift o...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
(Natural News) It is truly unavoidable to catch a cold or contract a disease, especially with today’s lifestyle trends and medical misinformation. A lot of the medicine we use to treat our health conditions may actually cause more harm than good. A St. Joseph’s Healthcare Hamilton and McMaster University joint study found that low doses...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
ConclusionThis draft genome sequence might provide important data for a better understanding of genomic aspects regarding the dissemination of CTX-M-8-producing E. coli in the human–animal–environment interface.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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