Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal study

This study aimed to investigate the rate of fluconazole-non-susceptible Cryptococcus neoformans in Southern Taiwan for the period 2001–2012 and analyze the risk factors for acquiring it among patients with invasive cryptococcosis. Methods: All enrolled strains were isolated from blood or cerebrospinal fluid samples of the included patients. If a patient had multiple positive results for C. neoformans, only the first instance was enrolled. Susceptibility testing was performed using the Clinical and Laboratory Standards Institutes M27-A3 broth micro-dilution method. The MIC interpretative criteria for susceptibility to fluconazole were ≤8 μg/ml. A total of 89 patients were included. Patients (n = 59) infected by fluconazole-susceptible strains were compared with those (n = 30) infected by non-susceptible strains. The patients’ demographic and clinical characteristics were analyzed. Results: The rate of fluconazole-non-susceptible C. neoformans in the study period significantly increased over time (p 
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Source Type: research

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by Sujiraphong Pharkjaksu, Kyung J. Kwon-Chung, John E. Bennett, Popchai Ngamskulrungroj Cryptococcosis has become a major global health problem since the advent of the HIV pandemic in 1980s. Although its molecular epidemiology is well-defined, using isolates recovered since then, no pre-HIV-pandemic era epidemiological data exist. We conducted a molecular epidemiological study using 228 isolates of theC.neoformans/C.gattii species complexes isolated before 1975. Genotypes were determined byURA5 restriction fragment length polymorphism analysis and multi-locus sequence typing. Population genetics were defined by nucleotid...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Publication date: Available online 24 September 2020Source: Journal de Mycologie MédicaleAuthor(s): Lurdeti Bastos da Silva, Douglas Bock, Gabriel Baracy Klafke, Karine Ortiz Sanchotene, Rossana Patricia Basso, Jéssica Louise Benelli, Vanice Rodrigues Poester, Felipe Almeida da Silva, Luciana Trilles, Cecília Bittencourt Severo, David A. Stevens, Melissa Orzechowski Xavier
Source: Journal of Medical Mycology - Category: Biology Source Type: research
PMID: 32986969 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Authors: Tags: Actas Dermosifiliogr Source Type: research
Conditions:   Cryptococcosis;   Lung Adenocarcinoma Intervention:   Diagnostic Test: A scoring system Sponsor:   Shanghai Pulmonary Hospital, Shanghai, China Recruiting
Source: - Category: Research Source Type: clinical trials
Cryptococcus species are environmental fungal pathogens and the causative agents of cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in the lung causing a primary infection. From this primary lung infection, fungal cells can eventually disseminate to other organs, particularly the brain, causing lethal meningoencephalitis. However, in most cases, the primary infection resolves with the formation of a lung granuloma. Upon severe immunodeficiency, dormant cryptococcal cells will start proliferating in the lung granuloma and eventually will disseminate to the brain. Many investigator...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
PMID: 32948385 [PubMed - as supplied by publisher]
Source: Asian Journal of Surgery - Category: Surgery Authors: Tags: Asian J Surg Source Type: research
Cryptococcus is a conditional pathogenic fungus causing cryptococcosis, which is one of the most serious fungal diseases faced by humans. Lateral flow immunochromatographic assay (LFA) is successfully applied to ...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
Manisha Paul, Mohit Bhatia, Ranjana Rohilla, Udayakumar Sasirekha, Neelam KaisthaIndian Journal of Medical Microbiology 2020 38(2):229-234 Cryptococcosis is a fungal disease with worldwide distribution and wide array of clinical manifestations, caused by encapsulated basidiomycetous yeasts called Cryptococcus spp. It has traditionally been considered an opportunistic infection known to occur in immunocompromised hosts, particularly those who are infected with human immunodeficiency virus. However, this infection has also been reported in phenotypically 'normal' or otherwise clinically non-immunocompromised patient...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
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